Zobrazeno 1 - 10
of 13
pro vyhledávání: '"D. M. Hushpulian"'
Autor:
Vladimir I. Tishkov, A. Yu. Khristichenko, D. M. Hushpulian, Sergey Kazakov, N. A. Smirnova, Andrey A. Poloznikov, Irina G. Gazaryan, A. A. Zakhariants
Publikováno v:
Moscow University Chemistry Bulletin. 74:180-185
Cell-based reporters expressing luciferase fusions with transcription factors or their protein stability domains can be considered as microbioreactors providing a way to directly monitor the stability of the luciferase labeled transcription factor or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c607d0139fb3a3a39056eebedb573ae9
https://doi.org/10.3103/s0027131419040047
https://doi.org/10.3103/s0027131419040047
Autor:
A. Yu. Khristichenko, Vladimir I. Tishkov, Irina G. Gazaryan, Irina N. Gaisina, A. I. Osipyants, N. A. Smirnova, D. M. Hushpulian, A. A. Poloznikov
Publikováno v:
Russian Chemical Bulletin. 68:168-173
The structural optimization of adaptaquin, viz., 7-(4-chlorophenyl)[(3-hydroxypyridin-2-yl)amino]methylquinolin-8-ol, a HIF (hypoxia inducible factor) prolyl hydroxylase inhibitor, was carried out. This was done by cell-based screening using cell lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ceacef42a51fbf9fd8b397dcb654a2d
https://doi.org/10.1007/s11172-019-2433-3
https://doi.org/10.1007/s11172-019-2433-3
Autor:
Julie Vignisse, Bobby Thomas, Natalia N. Starkova, Lucien Bettendorff, Meri Gerges, Flint Beal, Manuj Ahuja, Cliona Stack, Ceyhan Elipenahli, Irina G. Gazaryan, N. A. Smirnova, Magali Dumont, Anatoly A. Starkov, Gary E. Gibson, Shari Jainuddin, Victor Tapias, Sushama Wakade, Navneet Ammal Kaidery, Hui Xu, D. M. Hushpulian, Noel Y. Calingasan
Publikováno v:
Human Molecular Genetics. 27:2874-2892
Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and transketolase occur in Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507664ee62694dda9acf5b8e277c32c5
https://doi.org/10.1093/hmg/ddy201
https://doi.org/10.1093/hmg/ddy201
Autor:
Sergey Nikulin, N. A. Smirnova, A. Yu. Khristichenko, Andrey A. Poloznikov, Irina G. Gazaryan, A. A. Zakhariants, T. A. Chubar, A. I. Osipyants, D. M. Hushpulian, Vladimir I. Tishkov
Publikováno v:
Russian Chemical Bulletin. 67:150-156
Reporters expressing fusion proteins of HIF2 and HIF3 C-terminal oxygen degradable domain (ODD) with the firefly luciferase, HIF2 ODD-luc and HIF3 ODD-luc, were constructed and briefly characterized. Stable neuroblastoma cell lines expressing either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07620687cf9b2af3000f70bc2857f0a2
https://doi.org/10.1007/s11172-018-2051-5
https://doi.org/10.1007/s11172-018-2051-5
Autor:
N. A. Smirnova, Vladimir I. Tishkov, Irina G. Gazaryan, Sergey Nikulin, Andrey A. Poloznikov, A. Yu. Khristichenko, A. I. Osipyants, A. A. Zakhariants, T. A. Chubar, D. M. Hushpulian
Publikováno v:
Biochemistry (Moscow). 82:1207-1214
An organism naturally responds to hypoxia via stabilization of hypoxia-inducible factor (HIF). There are three isoforms of HIFα subunits whose stability is regulated by three isozymes of HIF prolyl hydroxylase (PHD1-3). Despite intense studies on re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c5f5201984a83f5e6ee601898213d2
https://doi.org/10.1134/s0006297917100145
https://doi.org/10.1134/s0006297917100145
Autor:
Alexander G. Tonevitsky, Sergey Nikulin, Irina N. Gaisina, D. M. Hushpulian, Andrey A. Poloznikov, Irina G. Gazaryan, Vladimir I. Tishkov, A. A. Zakhariants, N. A. Smirnova
Publikováno v:
Biochimie. 133:74-79
HIF prolyl hydroxylase is a major regulator of HIF stability. Branched tail oxyquinolines have been identified as specific inhibitors of HIF prolyl hydroxylase and recently demonstrated clear benefits in various scenarios of neuronal failure. The str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfa6a258dfe9f0b652d71902892e3cb
https://doi.org/10.1016/j.biochi.2016.12.004
https://doi.org/10.1016/j.biochi.2016.12.004
Autor:
D. M. Hushpulian, A. Yu. Khristichenko, Irina N. Gaisina, Vladimir I. Tishkov, Sergey Nikulin, N. A. Smirnova, Irina G. Gazaryan, Andrey A. Poloznikov
Publikováno v:
Russian Chemical Bulletin. 65:2970-2977
The screening of the library containing 320 drugs and biologically active compounds was carried out. The library was created for testing potent agents on Rett syndrome models (SMART library) using new-generation luciferase reporters to identify stabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32a3ed0bf1b2706406116adce816291c
https://doi.org/10.1007/s11172-016-1687-2
https://doi.org/10.1007/s11172-016-1687-2
Autor:
Vladimir I. Tishkov, D. M. Hushpulian, Irina G. Gazaryan, A. A. Zakhariants, Andrey A. Poloznikov, T. A. Osipova
Publikováno v:
Moscow University Chemistry Bulletin. 70:261-267
Benzimidazoles are drugs which target tubulin and are widely used to treat intestinal parasites. Four benzimidazoles are tested with the well-characterized and commercially available bacterial p-hydroxybenzoate hydroxylase (PHBH), which belongs to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0602ae21ee05a96b5b2067a0429e519
https://doi.org/10.3103/s0027131415060073
https://doi.org/10.3103/s0027131415060073
Autor:
A. A. Poloznikov, G.S. Zakharova, Vladimir I. Tishkov, D. M. Hushpulian, Irina G. Gazaryan, T. A. Chubar
Publikováno v:
Biochimie. 115:71-77
Tobacco anionic peroxidase (TOP) is known to effectively catalyze luminol oxidation without enhancers, in contrast to horseradish peroxidase (HRP). To pursue structure-activity relationship studies for TOP, two amino acids have been chosen for mutati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5919069ab69e28930fcadb6970e5421e
https://doi.org/10.1016/j.biochi.2015.04.021
https://doi.org/10.1016/j.biochi.2015.04.021
Autor:
Irina G. Gazaryan, A.A. Zakharyants, Natalia Moroz, Andrey A. Poloznikov, Vladimir I. Tishkov, D. M. Hushpulian, N. A. Smirnova
Publikováno v:
Russian Chemical Bulletin. 64:1671-1677
Hypoxia inducible factor (HIF) prolyl hydroxylases (PHD) belong to α-ketoglutarate-dependent non-heme iron dioxygenases catalyzing hydroxylation of HIF prolines. The catalytic domains of all three enzyme isoforms (PHD1–3) were expressed in E.coli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79735279086754835f1016788e2e1ede
https://doi.org/10.1007/s11172-015-1058-4
https://doi.org/10.1007/s11172-015-1058-4