Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas

Autor: D. M. Heijink, J. H. Kleibeuker, M. Jalving, W. Boersma-van Ekb, J. J. Koornstra, J. Wesseling, S. de Jong

Publikováno v: Cellular Oncology, Vol 29, Iss 5, Pp 409-419 (2007)

Background: TNF-Related Apoptosis Inducing Ligand (TRAIL) is a promising agent for the induction of apoptosis in neoplastic tissues. Important determinants of TRAIL sensitivity are two intracellular proteins of the TRAIL pathway, caspase-8 and its an

Externí odkaz: https://doaj.org/article/1bc75da155db41c583d474aba6fc12d8

Regulation of TRAIL receptor expression by -catenin in colorectal tumours

Autor: W. Boersma-van Ek, de Elisabeth G. E. Vries, Johannes Wesseling, D. M. Heijink, Jan J. Koornstra, Mathilde Jalving, Nynke Zwart, Jan H. Kleibeuker, de Steven Jong, Willem Sluiter

Publikováno v: CARCINOGENESIS, 35(5), 1092-1099. Oxford University Press

Expression of the pro-apoptotic TRAIL receptors is regulated, at least in part, by beta-catenin. We show that beta-catenin co-localizes with DR4/5 in human and mouse colorectal tumours and that downregulation of beta-catenin in cell line models reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0118da6ec498cd13d800db5d1c92325
https://doi.org/10.1093/carcin/bgt484

Total Abdominal 18F-FDG Uptake Reflects Intestinal Adenoma Burden in Apc Mutant Mice

Autor: Dorenda Oosterhuis, Wouter B. Nagengast, Elisabeth G.E. de Vries, D. M. Heijink, Adrienne H. Brouwers, Jan H. Kleibeuker, Steven de Jong, Jan J. Koornstra

Publikováno v: Journal of Nuclear Medicine, 52(3), 431-436. SOC NUCLEAR MEDICINE INC

Apc mutant (Apc(Min)) mice develop multiple adenomas in their intestines and are widely used to study colorectal carcinogenesis and chemopreventive approaches. Molecular imaging of intestinal adenomas could potentially provide noninvasive longitudina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7dfe3b574ecc37ae873a0506765562b
https://doi.org/10.2967/jnumed.110.083956

Independent induction of caspase-8 and cFLIP expression during colorectal carcinogenesis in sporadic and HNPCC adenomas and carcinomas

Autor: de Steven Jong, Mathilde Jalving, Jelle Wesseling, W. Boersma-van Ek, Jan H. Kleibeuker, D. M. Heijink, Jan J. Koornstra

Publikováno v: Cellular oncology, 29(5), 409-419. SPRINGER
Cellular Oncology, Vol 29, Iss 5, Pp 409-419 (2007)
Cellular Oncology : the Official Journal of the International Society for Cellular Oncology
Europe PubMed Central

Background: TNF-Related Apoptosis Inducing Ligand (TRAIL) is a promising agent for the induction of apoptosis in neoplastic tissues. Important determinants of TRAIL sensitivity are two intracellular proteins of the TRAIL pathway, caspase-8 and its an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5f68b029302aecd00dca920afd0a5d
https://research.rug.nl/en/publications/3d431baf-0b38-4b55-b66a-8117271ec6ab

A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer

Autor: de Elisabeth G. E. Vries, Dorenda Oosterhuis, Rudolf S N Fehrmann, D. M. Heijink, Jan J. Koornstra, van der Ate Zee, de Steven Jong, Jan H. Kleibeuker

Publikováno v: ONCOGENE, 30(17), 2026-2036. Nature Publishing Group

Comparing normal colorectal mucosa and adenomas focusing on deregulated pathways obtains insight into the biological processes of early colorectal carcinogenesis. Publicly available microarray expression data from 26 normal mucosa and 47 adenoma samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5cc04a6057cb33c1b700d39423d707
https://research.rug.nl/en/publications/69ec7c24-43b8-44b2-a794-c1020d254c2d