Zobrazeno 1 - 10
of 12
pro vyhledávání: '"D. M. Gapinski"'
Publikováno v:
Journal of Medicinal Chemistry. 33:2807-2813
A series of lipophilic benzophenone dicarboxylic acid derivatives were found to inhibit the binding of the potent chemotaxin leukotriene B4 (LTB4) to its receptor on intact human neutrophils. Activity at the LTB4 receptor was determined by using a [3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e289e6ecd468b0aaed745becf5588265
https://doi.org/10.1021/jm00172a020
https://doi.org/10.1021/jm00172a020
Publikováno v:
Journal of Medicinal Chemistry. 33:2798-2807
A series of lipophilic benzophenone dicarboxylic acid derivatives was prepared which inhibited the binding of the potent chemotaxin leukotriene B4 to its receptor(s) on intact human neutrophils. With a radioligand-binding assay as a measure of recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b8010e74298d44e41d402317ab43b5
https://doi.org/10.1021/jm00172a019
https://doi.org/10.1021/jm00172a019
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 263(3)
LY223982, (E)-5-(3-carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5- hexenyl)oxy)benzenepropanoic acid, is a newly discovered potent inhibitor of specific binding of leukotriene B4 (LTB4) to its receptor on human neutrophils. This study demonstrated that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3d2682789ca37d778dd5fc25c2a4ad0
https://pubmed.ncbi.nlm.nih.gov/1335049
https://pubmed.ncbi.nlm.nih.gov/1335049
Publikováno v:
Receptor. 2(3)
A series of lipophilic benzophenone dicarboxylic acids have been shown to be inhibitors of the binding of LTB4 to its receptors on intact human neutrophils (Gapinski et al. (1990). Structure-activity relationships indicated that maximum activity was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a04a1ff1655fcc323ab2889a80eacd8d
https://pubmed.ncbi.nlm.nih.gov/1335328
https://pubmed.ncbi.nlm.nih.gov/1335328
Publikováno v:
Journal of the American Chemical Society. 109:5437-5446
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13e243091ec459e6c2e957fe8f30082c
https://doi.org/10.1021/ja00252a021
https://doi.org/10.1021/ja00252a021
Autor:
D. M. Gapinski, E. Vedejs
Publikováno v:
Journal of the American Chemical Society. 105:5058-5061
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2cca59ca5d115f86033626df17c08cd
https://doi.org/10.1021/ja00353a034
https://doi.org/10.1021/ja00353a034
Autor:
E. VEDEJS, D. M. GAPINSKI
Publikováno v:
Chemischer Informationsdienst. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bae020c93d2e867ba1fc8aef36a8f94
https://doi.org/10.1002/chin.198345126
https://doi.org/10.1002/chin.198345126
Publikováno v:
Chemischer Informationsdienst. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f379f445201a51bde3b79966da0ce0ff
https://doi.org/10.1002/chin.198220252
https://doi.org/10.1002/chin.198220252
Publikováno v:
Journal of medicinal chemistry. 31(1)
Analogues of the leukotriene D4/E4 receptor antagonist LY171883 (1a) were synthesized in which the tetrazole was linked to the hydroxyacetophenone moiety by an all-methylene carbon chain. A key step in the synthesis involved a Wittig olefin-forming r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1314d3e9dff06029c5e420ca03581809
https://pubmed.ncbi.nlm.nih.gov/2826785
https://pubmed.ncbi.nlm.nih.gov/2826785
Publikováno v:
ChemInform. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98610e8b5170ca8d1cd6ac90abbb7fe0
https://doi.org/10.1002/chin.198751241
https://doi.org/10.1002/chin.198751241