Výsledky vyhledávání - "D. M. Fishwild"

Characterization of the increased cytotoxicity of gelonin anti-T cell immunoconjugates compared with ricin A chain immunoconjugates

Autor: D M Fishwild, S L Bernhard, H.-M. Wu, S F Carroll

Publikováno v: Clinical and Experimental Immunology. 97:10-18

SUMMARY Ribosomal inactivating proteins such as gelonin (Gel) and ricin A chain (RTA) conjugated to MoAbs bind to specific target cells, and upon internalization inhibit protein synthesis, ultimately resulting in cell death. We report here that Gel a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ccad0421b4fbf3135c588afe071d5c2
https://doi.org/10.1111/j.1365-2249.1994.tb06572.x

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Cytotoxicity against human peripheral blood mononuclear cells and T cell lines mediated by anti-T cell immunotoxins in the absence of added potentiator

Autor: H.-M. Wu, D. M. Fishwild, M. O. Staskawicz, S. F. Carroll

Publikováno v: Clinical and Experimental Immunology. 86:506-513

SUMMARY Several in vitro assays have indicated that anti-T cell immunotoxins (IT), composed of monoclonal antibodies (MoAbs)conjugated to ricin A chain (RTA), are maximally effective against T cells only in the presence of potentiators. It was though

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510edbf6431ce3c1eef9998dd18022d6
https://doi.org/10.1111/j.1365-2249.1991.tb02961.x

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Administration of an anti-CD5 immunoconjugate to patients with rheumatoid arthritis: effect on peripheral blood mononuclear cells and in vitro immune function

Autor: D M, Fishwild, V, Strand

Publikováno v: The Journal of rheumatology. 21(4)

An immunoconjugate, CD5 Plus, composed of ricin A chain and murine IgG1 anti-CD5 monoclonal antibody is under investigation for treatment of rheumatoid arthritis. To understand better the mechanism of action of this agent, alterations in immune funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::603938ab4379c801a5d0ff5ba06bac51
https://pubmed.ncbi.nlm.nih.gov/7518519

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Gelonin analogs with engineered cysteine residues form antibody immunoconjugates with unique properties

Autor: M, Better, S L, Bernhard, D M, Fishwild, P A, Nolan, R J, Bauer, A H, Kung, S F, Carroll

Publikováno v: The Journal of biological chemistry. 269(13)

We engineered the ribosome inactivating-protein gelonin (Gel) to generate a family of Gel analogs, each with a single unpaired cysteine residue. The cysteine sites coincide with surface-accessible loops in the probable three-dimensional structure of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::370c01fa246ebef67428a4193d296138
https://pubmed.ncbi.nlm.nih.gov/8144553

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Potent anti-CD5 ricin A chain immunoconjugates from bacterially produced Fab' and F(ab')2

Autor: M. Better, Shau-Ping Lei, J. A. Lane, A. H. Horwitz, D. M. Fishwild, S. L. Bernhard, S. F. Carroll

We have used genetic engineering to obtain secretion of anti-human CD5 antibody fragments from Escherichia coli for conjugation to the 30-kDa form of ricin A chain (RTA30). This was accomplished by introducing stop codons at two positions in the hing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98957f610a6600a4d62a64f733496077
https://europepmc.org/articles/PMC45682/

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Binding Characteristics of the Antiendotoxin Antibody Xomen-E5 to Bacterial Whole-Cell Antigens

Autor: K. J. Gorelick, E. Lim, D. M. Fishwild, D. M. Wood, D. T. Reardan, K. D. Knebel, J. B. Parent, P. J. Conlon, P. W. Trown

Publikováno v: Host Defense Dysfunction in Trauma, Shock and Sepsis ISBN: 9783642774072

Sepsis is a common, life-threatening complication of infection with gram-negative bacteria. While the pathophysiology of gram-negative sepsis has not been fully elucidated, a significant portion of the clinical syndrome can probably be attributed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7e4a79125a68e7c3f0e0a675e63734e
https://doi.org/10.1007/978-3-642-77405-8_156

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Activity of recombinant mitogillin and mitogillin immunoconjugates

Autor: M, Better, S L, Bernhard, S P, Lei, D M, Fishwild, S F, Carroll

Publikováno v: The Journal of biological chemistry. 267(23)

A synthetic gene for the Aspergillus protein toxin mitogillin has been synthesized and expressed in Escherichia coli. The recombinant mitogillin is a potent inhibitor of protein synthesis in vitro with an IC50 of 9.7 pM. Immunoconjugates of recombina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::10f818126634a2056744bc7f9c2079c6
https://pubmed.ncbi.nlm.nih.gov/1644844

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Efficacy of an anti-CD7-ricin A chain immunoconjugate in a novel murine model of human T-cell leukemia

Autor: D M, Fishwild, S, Aberle, S L, Bernhard, A H, Kung

Publikováno v: Cancer research. 52(11)

In vivo efficacy testing of monoclonal antibody-based drugs specific for human leukemias is hampered by the paucity of suitable animal models, due in part to the inability of many anti-human monoclonal antibodies to cross-react with antigens expresse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6acf4191edfb1d077716f643c372c397
https://pubmed.ncbi.nlm.nih.gov/1375534

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