Výsledky vyhledávání

Discovery and Structure-Activity Relationships of Sulfonamide ETA-Selective Antagonists

Autor: P D, Stein, D M, Floyd, S, Bisaha, J, Dickey, R N, Girotra, J Z, Gougoutas, M, Kozlowski, V G, Lee, E C, Liu, M F, Malley

Publikováno v: Journal of Medicinal Chemistry. 38:1344-1354

Random screening of compounds in an ET A receptor binding assay led to the discovery of a class of benzenesulfonamide ligands. Optimization led to the development of 5-amino-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamides which were functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f062a0d1f2aa237276003c16a9085a69
https://doi.org/10.1021/jm00008a013

Zobrazit plný text záznamu

Benzazepinone calcium channel blockers. 2. Structure activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones

Autor: D M, Floyd, S D, Kimball, J, Krapcho, J, Das, C F, Turk, R V, Moquin, M W, Lago, K J, Duff, V G, Lee, R E, White

Publikováno v: Journal of Medicinal Chemistry. 35:756-772

As part of a program to discover potent antihypertensive analogues of diltiazem (3a), we prepared 1-benzazepin-2-ones (4). Benzazepinones competitively displace radiolabeled diltiazem, and show the same absolute stereochemical preferences at the calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d336d4ef2d8cd26d3c72701eb7dbb98c
https://doi.org/10.1021/jm00082a018

Zobrazit plný text záznamu

Site-specific biotinylation. A novel approach and its application to endothelin-1 analogs and PTH-analog

Autor: S, Natarajan, S M, Festin, A, Hedberg, E C, Liu, D M, Floyd, J T, Hunt

Publikováno v: International journal of peptide and protein research. 40(6)

We have developed an expeditious method for the incorporation of the biotinylaminocaproyl moiety on the epsilon-amino group of a lysine residue within a peptide chain in a site-specific manner. Using t-Boc chemistry for the solid phase synthesis appr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59f530f464ce08e758b563dde005c8d4
https://pubmed.ncbi.nlm.nih.gov/1286942

Zobrazit plný text záznamu

Pharmacological characterization of potent, long-acting thromboxane receptor antagonists, SQ 33,261 and SQ 33,552

Autor: D N, Harris, I M, Michel, H J, Goldenberg, K S, Hartl, G T, Allen, T E, Steinbacher, W A, Schumacher, W C, Han, S E, Hall, D M, Floyd

Publikováno v: The Journal of pharmacology and experimental therapeutics. 261(1)

SQ 33,261 ([1S-[1 alpha,2 alpha(Z),3 alpha,4 alpha]]-6-[3-[[2- [(phenylamino)carbonyl]hydrazono]methyl]-7-oxabicyclo[2.2.1]hept-2 - yl]-4-hexenoic acid) and SQ 33,552 ([1S-[1 alpha,2 alpha(Z),3 alpha,4 alpha]]-6-[3-[[[[(4- chlorophenyl)amino]carbonyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::891bae37de400435f0db812bf40bf2a8
https://pubmed.ncbi.nlm.nih.gov/1532833

Zobrazit plný text záznamu

ChemInform Abstract: Dihydropyrimidine Calcium Channel Blockers: 2-Heterosubstituted 4-Aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines

Autor: K. S. ATWAL, G. C. ROVNYAK, J. SCHWARTZ, S. MORELAND, A. HEDBERG, J. Z. GOUGOUTAS, M. F. MALLEY, D. M. FLOYD

Publikováno v: ChemInform. 21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b74d84c1c88cb1a5752ee95c26393df
https://doi.org/10.1002/chin.199048184

Zobrazit plný text záznamu

Dihydropyrimidine calcium channel blockers. 2. 3-substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines

Autor: K S, Atwal, G C, Rovnyak, S D, Kimball, D M, Floyd, S, Moreland, B N, Swanson, J Z, Gougoutas, J, Schwartz, K M, Smillie, M F, Malley

Publikováno v: Journal of medicinal chemistry. 33(9)

To enhance the intrinsic potency of dihydropyrimidine calcium channel blockers, we have modified the structure of previously described 2-heteroalkyl-1,4-dihydropyrimidines 2 to 3-substituted 1,4-dihydropyrimidines 3. Structure-activity studies using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b50171115466f7a8d201b7c6471920c
https://pubmed.ncbi.nlm.nih.gov/2391701

Zobrazit plný text záznamu

SQ 27,786 and SQ 28,853

Autor: J. E. Sundeen, Jack M. DeForrest, James R. Powell, D. M. Floyd, Thomas L. Waldron

Publikováno v: Journal of Cardiovascular Pharmacology. 9:154-159

SQ 27,786 and SQ 28,853 were designed to possess both angiotensin converting enzyme (ACE) inhibitory and diuretic properties. Both compounds were given to conscious male Sprague-Dawley rats and mongrel female dogs to determine ACE inhibitory and diur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053b86ff4575ed98156d6332090babac
https://doi.org/10.1097/00005344-198702000-00005

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání