Výsledky vyhledávání - "D. M. F. Edwards"

PHARMACOKINETICS OF REBOXETINE IN HEALTHY VOLUNTEERS. SINGLE AGAINST REPEATED ORAL DOSES AND LACK OF ENZYMATIC ALTERATIONS

Autor: C. Pellizzoni, Italo Poggesi, N. P. Jørgensen, D. M. F. Edwards, M. Strolin Benedetti, E. Paus

Publikováno v: Biopharmaceutics & Drug Disposition. 17:623-633

The pharmacokinetics of reboxetine have been investigated in 12 healthy male volunteers after a single 2 mg dose of reboxetine and at steady state, following the last administration of a multiple-dose regimen (2mg twice a day for 5 1/2 d). Reboxetine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84909d71a9b5a8829257112398521902
https://doi.org/10.1002/(sici)1099-081x(199610)17:7<623::aid-bdd978>3.0.co

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Pharmacokinetics of reboxetine in healthy volunteers. Single oral doses, linearity and plasma protein binding

Autor: C. Pellizzoni, Maurizio Rocchetti, A. Dubini, M. G. Castelli, D. M. F. Edwards, A. Berardi, Italo Poggesi, H. P. Breuel, M. Strolin Benedetti, E. Frigerio

Publikováno v: Biopharmaceutics & Drug Disposition. 16:443-460

The pharmacokinetics of reboxetine, a new antidepressant agent, were found to be close to linear in a crossover study comparing administration of single 2, 3, 4, and 5 mg capsule doses in 15 healthy male volunteers, and in the same study the capsules

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b332a3f90cb92d561b2217ca1c1462
https://doi.org/10.1002/bdd.2510160603

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Pharmacokinetics of acipimox and of its N-deoxy metabolite following single and repeated oral administration of a sustained release formulation to healthy volunteers

Autor: C. Advenier, F. Ruff, C. Efthymiopoulos, D. M. F. Edwards, R. Bianchini, M. Strolin-Benedetti, L. Musatti

Publikováno v: International Journal of Pharmaceutics. 95:127-133

Acipimox is a lipid lowering agent currently used for the treatment of hyperlipoproteinemia at a dose of 250 mg thrice daily. A sustained release (SR) formulation, containing 500 mg acipimox, has been developed with the aim of reducing the number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1979637a6eeb2cf05a6c1048b15fdbde
https://doi.org/10.1016/0378-5173(93)90399-z

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Pharmacodynamics and relative bioavailability of cabergoline tablets vs solution in healthy volunteers

Autor: C.A. Bizollon, E. Pianezzola, M. Strolin Benedetti, D. M. F. Edwards, G. Sassolas, Italo Poggesi, Stefano Persiani, G. Piscitelli

Publikováno v: Journal of pharmaceutical sciences. 83(10)

The effect of formulation on the urinary pharmacokinetics, pharmacodynamics, and relative bioavailability of cabergoline was investigated. Twelve healthy female volunteers, aged 23-35 years, were treated, according to an open, randomized, crossover d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b0863ffc5322061d65910fcd58c383
https://pubmed.ncbi.nlm.nih.gov/7884663

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