Zobrazeno 1 - 10
of 10
pro vyhledávání: '"D. M. Dulik"'
Publikováno v:
Xenobiotica. 22:325-334
1. Pentachlorophenyl methyl sulphoxide and pentachlorophenyl methyl sulphone were found to be substrates for microsomal and cytosolic glutathione-S-transferase of rabbit, monkey, chicken and human liver, covalently immobilized on beaded sepharose. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa87200a3ef3f18e644c051e1cf5e05
https://doi.org/10.3109/00498259209046644
https://doi.org/10.3109/00498259209046644
Autor:
G Y, Kuo, D M, Dulik
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31764cc868a4877233225c9006d3d09c
https://pubmed.ncbi.nlm.nih.gov/8565774
https://pubmed.ncbi.nlm.nih.gov/8565774
Autor:
W. H. Soine, D. M. Dulik
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 20:527-535
The synthesis of 4,6-2H2-1,2,3-benzenetriol from 1,2,3-benzenetriol was possible under both acid and base catalyzed conditions. However, under simulated physiological conditions it was observed that the label underwent exchange and was lost. Using a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb1e775ebaa36149cd0d570c9ba82a90
https://doi.org/10.1002/jlcr.2580200411
https://doi.org/10.1002/jlcr.2580200411
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 25:1021-1025
The enzyme catalyzed displacement of the methyl sulfonyl group from pentachlorophenyl methyl sulfone, the m-chloroperoxybenzoic acid oxidation of methyl mercaptan and the reaction of methyllithium with sulfur dioxide are methods described for the syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04faf27d6bfee83e6ead576207824a68
https://doi.org/10.1002/jlcr.2580250915
https://doi.org/10.1002/jlcr.2580250915
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 14(3)
Glutathione transferase activity was shown to be present in an immobilized preparation of microsomal protein. Chlorodinitrobenzene, ethacrynic acid, captopril, styrene oxide, and iminocyclophosphamide were found to be substrates, each providing a dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f231083915e52a5ffe17454b20e5f680
https://pubmed.ncbi.nlm.nih.gov/2872031
https://pubmed.ncbi.nlm.nih.gov/2872031
Autor:
D M, Dulik, C, Fenselau
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(4)
The utility of immobilized microsomal enzymes from rabbit liver for the synthesis of a variety of conjugated drug metabolites has been demonstrated in our laboratory. Here, this capability is extended to microsomal preparations from monkey and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d730d3859a48cc6ec8f517ffd447c50
https://pubmed.ncbi.nlm.nih.gov/2888619
https://pubmed.ncbi.nlm.nih.gov/2888619
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(6)
The enantioselective glucuronidation of several racemic 2-arylproprionic acids (naproxen, ibuprofen, and benoxaprofen) was investigated in vitro with immobilized microsomal protein from human, rhesus monkey, and rabbit liver as the source of UDP-gluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc13879351a3a127c614eb4b48e149d6
https://pubmed.ncbi.nlm.nih.gov/2893700
https://pubmed.ncbi.nlm.nih.gov/2893700
Autor:
D M, Dulik, C, Fenselau
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 15(2)
One of the conjugates of melphalan, characterized following incubation with glutathione (GSH) and immobilized microsomal glutathione-S-transferases, has been identified as 4-(glutathionyl)-phenylalanine. This conjugate is formed by displacement of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f134bdcce7131aa83d34e22661df30a
https://pubmed.ncbi.nlm.nih.gov/2882977
https://pubmed.ncbi.nlm.nih.gov/2882977
Publikováno v:
Advances in experimental medicine and biology. 197
1-O-acyl glucuronides are reactive Phase II metabolites which can alkylate chemical nucleophiles. Industrial sulfate ester mixed anhydrides have been reported to be active acylating agents. This study was undertaken in order to establish that sulfate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05b193a980667fd36862cc299fd68c85
https://pubmed.ncbi.nlm.nih.gov/3094339
https://pubmed.ncbi.nlm.nih.gov/3094339
Autor:
D. M. Dulik, W. H. Soine
Publikováno v:
Clinical toxicology. 18(6)
(1981). Color Test for Detection of 1 -Piperidinocyclohexanecarbonitrile (PCC) in Illicit Phencyclidine. Clinical Toxicology: Vol. 18, No. 6, pp. 737-742.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f242ff6a57232b895102f0efe1237f9
https://pubmed.ncbi.nlm.nih.gov/7273679
https://pubmed.ncbi.nlm.nih.gov/7273679