Development of Good Manufacturing Practice-Compatible Isolation and Culture Methods for Human Olfactory Mucosa-Derived Mesenchymal Stromal Cells

Autor: Christopher J. Kelly, Susan L. Lindsay, Rebecca Sherrard Smith, Siew Keh, Kyle T. Cunningham, Katja Thümmler, Rick M. Maizels, John D. M. Campbell, Susan C. Barnett

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 2, p 743 (2024)

Demyelination in the central nervous system (CNS) resulting from injury or disease can cause loss of nerve function and paralysis. Cell therapies intended to promote remyelination of axons are a promising avenue of treatment, with mesenchymal stromal

Externí odkaz: https://doaj.org/article/44c61ad8c0c742d49709078658397db6

Chemokines and their receptors: predictors of the therapeutic potential of mesenchymal stromal cells

Autor: Nerea Cuesta-Gomez, Gerard J. Graham, John D. M. Campbell

Publikováno v: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)

Abstract Multipotent mesenchymal stromal cells (MSCs) are promising cellular therapeutics for the treatment of inflammatory and degenerative disorders due to their anti-inflammatory, immunomodulatory and regenerative potentials. MSCs can be sourced f

Externí odkaz: https://doaj.org/article/a888e7ce3d414a8bb7cc212c7879a0e6

Study protocol: a multicentre, open-label, parallel-group, phase 2, randomised controlled trial of autologous macrophage therapy for liver cirrhosis (MATCH)

Autor: Catriona Graham, John F Dillon, Scott Semple, Neil Lachlan, Alasdair R Fraser, Jonathan Andrew Fallowfield, Francesca Moroni, Mark Macmillan, Thomas Manship, Stuart J Forbes, Paul Noel Brennan, Alison Glover, David M Morris, Chloe Pass, Neil W A McGowan, Marc L Turner, John D M Campbell

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Introduction Liver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or proregenerative medi

Externí odkaz: https://doaj.org/article/89f7b18180ca494fa34b4ea6b54326f8

1,25-Dihydroxyvitamin D3 Restrains CD4+ T Cell Priming Ability of CD11c+ Dendritic Cells by Upregulating Expression of CD31

Autor: Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D. M. Campbell, Daniel Y. Soong, Nadine Kamenjarin, Richard J. Mellanby

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several aut

Externí odkaz: https://doaj.org/article/5a764644ca3f4a1bb43f1fe8c127100e

Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis

Autor: Anne P.M. Atkinson, Benjamin J. Dwyer, Neil W. A. McGowan, Laura Bailey, Audrey Laurie, Paul Burgoyne, Stuart J. Forbes, John D. M. Campbell, Joanna Moore, Chloe Pass, Marc Turner, Alasdair R. Fraser, Akib Hamid

Publikováno v: Cytotherapy
Fraser, A R, Pass, C, Burgoyne, P, Atkinson, A, Bailey, L, Laurie, A, W A McGowan, N, Hamid, A, Moore, J K, Dwyer, B J, Turner, M L, Forbes, S J & Campbell, J D M 2017, ' Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages : A novel cellular therapeutic for liver cirrhosis ', Cytotherapy . https://doi.org/10.1016/j.jcyt.2017.05.009

BACKGROUND AIMS: Autologous macrophage therapy represents a potentially significant therapeutic advance for the treatment of severe progressive liver cirrhosis. Administration of macrophages has been shown to reduce inflammation and drive fibrotic sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38c1401e3b5425cd575a365184c9fa0
http://europepmc.org/articles/PMC5571439