Zobrazeno 1 - 10
of 65
pro vyhledávání: '"D. Lynn Kirkpatrick"'
Autor:
D. Lynn Kirkpatrick, Cari Evans, Linda A. Pestano, Jeffrey Millard, Matthew Johnston, Emily Mick, William K. Schmidt
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract PF614, a trypsin‐activated abuse protection oxycodone prodrug designed to reduce recreational drug abuse, was compared to OxyContin for safety and pharmacokinetics (PKs) of plasma oxycodone following oral administration. This study was a t
Externí odkaz:
https://doaj.org/article/ff177eccb53f41dfa9ae01919fad64a1
Autor:
Olga Gliko, R. Bruce Weisman, D. Lynn Kirkpatrick, Geoffrey Bartholomeusz, Anton Naumov, Michelle Weiss
Publikováno v:
Materials, Vol 5, Iss 2, Pp 278-301 (2012)
Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nano
Externí odkaz:
https://doaj.org/article/7b0c0e6906724b2bac7fc123bbc131e3
Autor:
Jeffrey Millard, D. Lynn Kirkpatrick
In the current COVID-19 pandemic context, Ensysce and its subsidiary Covistat have been working to repurpose nafamostat mesylate as an effective oral and inhalation treatment against SARS-CoV-2 infection. Prior reports used cell lines to demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::889474f7661ac007ebb85a1579ed585e
https://doi.org/10.1101/2020.09.16.300483
https://doi.org/10.1101/2020.09.16.300483
Autor:
Md. Tanvir Hasan, Elizabeth Campbell, Veronica Lyle, Anton V. Naumov, D. Lynn Kirkpatrick, Olga Sizova, Giridhar R. Akkaraju
Publikováno v:
Cancers
Cancers, Vol 11, Iss 8, p 1175 (2019)
Volume 11
Issue 8
Cancers, Vol 11, Iss 8, p 1175 (2019)
Volume 11
Issue 8
Single-walled carbon nanotubes (SWCNTs) can serve as drug delivery/biological imaging agents, as they exhibit intrinsic fluorescence in the near-infrared, allowing for deeper tissue imaging while providing therapeutic transport. In this work, CoMoCAT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420867d237e899a24e32e90455525315
http://europepmc.org/articles/PMC6721580
http://europepmc.org/articles/PMC6721580
Autor:
Brian P. James, John J. Tentler, Stacey M. Bagby, Garth Powis, D. Lynn Kirkpatrick, Steven E. Robinson, Robert Lemos, S. Gail Eckhardt, William A. Robinson
Publikováno v:
Cancer Research. 75:A2-29
Phosphatidylinositol 3-kinase/phosphatidylinositide-dependent protein kinase 1 (PDPK1)/Akt signaling is activated in many cancers, and is associated with mutational loss of PTEN function, or activation of Phosphatidylinositide-3-kinase (PI3K). Activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35dcdcb51b7dad29fa3839cea3c5eccb
https://doi.org/10.1158/1538-7445.transcagen-a2-29
https://doi.org/10.1158/1538-7445.transcagen-a2-29
Autor:
D Lynn Kirkpatrick, William K Schmidt, Julie D. Seroogy, Ricardo Morales, Craig O. Husfeld, Thomas E. Jenkins, John Cremin
Publikováno v:
Journal of opioid management. 13(1)
Objective: The need for pain medication which will not lead to abuse is well recognized. Ensysce has designed prodrug analogs of the commonly used pain medications including hydromorphone, oxycodone (OC), hydrocodone, and morphine that limit their us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef60a409abbfebf46323db737ca70959
https://pubmed.ncbi.nlm.nih.gov/28345745
https://pubmed.ncbi.nlm.nih.gov/28345745
Autor:
Garth Powis, D. Lynn Kirkpatrick
Publikováno v:
Antioxidantsredox signaling. 26(6)
There are a number of redox-active anticancer agents currently in development based on the premise that altered redox homeostasis is necessary for cancer cell's survival. Recent Advances: This review focuses on the relatively few agents that target c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb34488aa5a629cd984bc221315bcc4d
https://pubmed.ncbi.nlm.nih.gov/26983373
https://pubmed.ncbi.nlm.nih.gov/26983373
Autor:
Anton V. Naumov, D. Lynn Kirkpatrick, Geoffrey Bartholomeusz, Michelle Weiss, R. Bruce Weisman, Olga Gliko
Publikováno v:
Materials, Vol 5, Iss 2, Pp 278-301 (2012)
Materials; Volume 5; Issue 2; Pages: 278-301
Materials
Materials; Volume 5; Issue 2; Pages: 278-301
Materials
Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f02c4fd691cd7053091f5a7a20ed0f64
http://www.mdpi.com/1996-1944/5/2/278/
http://www.mdpi.com/1996-1944/5/2/278/
Autor:
Garth Powis, Eugene A. Mash, Emmanuelle J. Meuillet, Ali M. Ahad, John Kingston, Lei Du-Cuny, Robert Lemos, Nathan T. Ihle, Shuxing Zhang, D. Lynn Kirkpatrick, Jörg J. Jacoby, Li Li Zhou, Sylvestor A. Moses, Song Zuohe, Ryan Watkins, Roy S. Herbst
Publikováno v:
Molecular Cancer Therapeutics. 9:706-717
Phosphatidylinositol 3-kinase/phosphatidylinositide-dependent protein kinase 1 (PDPK1)/Akt signaling plays a critical role in activating proliferation and survival pathways within cancer cells. We report the molecular pharmacology and antitumor activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4db7ac75e0b8051aba3d0bb92a736c3
https://doi.org/10.1158/1535-7163.mct-09-0985
https://doi.org/10.1158/1535-7163.mct-09-0985
Autor:
W. K. Alfred Yung, Ruijun Shen, Yiling Lu, James A. Bankson, Dimpy Koul, Sabrina M. Ronen, Yasuko Kondo, Yong Wan Kim, D. Lynn Kirkpatrick, Garth Powis
Publikováno v:
Neuro-Oncology. 12:559-569
The phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway is critical in glioblastomas. Loss of PTEN, a negative regulator of the PI3K pathway or activated PI3K/Akt pathway that drive increased proliferation, survival, neovascularization, glycol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960c33759feed5d6ccd7bd60e13b3208
https://doi.org/10.1093/neuonc/nop058
https://doi.org/10.1093/neuonc/nop058