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An adenovirus-simian immunodeficiency virus env vaccine elicits humoral, cellular, and mucosal immune responses in rhesus macaques and decreases viral burden following vaginal challenge

Autor: John H. Eldridge, S. M. Cheng, Michael D. Lubeck, Marjorie Robert-Guroff, S. L. Buge, P. D. Markham, Christopher J. Miller, Stephen A. Udem, S. Alipanah, Narender K. Kalyan, Ersell Richardson

Publikováno v: Journal of Virology. 71:8531-8541

Six female rhesus macaques were immunized orally and intranasally at 0 weeks and intratracheally at 12 weeks with an adenovirus type 5 host range mutant (Ad5hr)-simian immunodeficiency virus SIVsm env recombinant and at 24 and 36 weeks with native SI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79821c9c219dcd4cf3137b8457236c57
https://doi.org/10.1128/jvi.71.11.8531-8541.1997

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Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Publikováno v: Nature Medicine. 3:651-658

A combination AIDS vaccine approach consisting of priming with adenovirus-HIV-1MN gp160 recombinants followed by boosting with HIV-1SF2 gp120 was evaluated in chimpanzees. Long-lasting protection, requiring only three immunizations, was achieved agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10775f6b9d04dd0a56fd61322128d0d7
https://doi.org/10.1038/nm0697-651

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Replication and immunogenicity of Ad7-, Ad4-, and Ad5-hepatitis B virus surface antigen recombinants, with or without a portion of E3 region, in chimpanzees

Autor: Bheem M. Bhat, Michael D. Lubeck, Surendra K. Dheer, Krishna K. Murthy, Murty Chengalvala, Robert H. Purcell, Ramesh A. Bhat

Publikováno v: Vaccine. 15:335-339

Human adenovirus vectors containing intact or largely deleted E3 region were used to construct adenovirus-hepatitis B recombinant viruses (Ad-HepB) and shown to produce substantial amount of recombinant protein, hepatitis B surface antigen (HBsAg), i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec693f114ee7b01073f6658f05f4e560
https://doi.org/10.1016/s0264-410x(96)00174-0

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Isolation and characterization of a highly attenuated respiratory syncytial virus (RSV) vaccine candidate by mutagenesis of the incompletely attenuated RSV A2 ts-1 NG-1 mutant virus

Autor: Robert M. Chanock, Kuo-Hom Lee Hsu, James E. Crowe, Brian R. Murphy, Michael D. Lubeck, Alan R. Davis, Paul P. Hung

Publikováno v: Vaccine. 13:509-515

Ts-1, a temperature sensitive (ts) mutant of RSV, was previously derived from RSV A2 virus by mutagenesis with 5-fluorouracil (5-FU). Ts-1 was attenuated for adult volunteers and seropositive children but retained a low level of virulence in seronega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e25df078e34fc290d7de80f069c047
https://doi.org/10.1016/0264-410x(94)00002-5

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Immunogenicity of Recombinant Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees Following Intranasal Administration

Autor: Mark S. Wade, Bheem M. Bhat, Surendra K. Dheer, Pranab K. Chanda, Ramesh A. Bhat, Michael D. Lubeck, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Paul P. Hung, Krishna K. Murthy, Murty Chengalvala, Alan R. Davis, Robert J. Natuk, Satoshi Mizutani

Publikováno v: AIDS Research and Human Retroviruses. 10:1443-1449

Recombinant adenovirus (Ad)-human immunodeficiency virus (HIV) vaccines expressing HIVIIIB Env and Gag proteins were evaluated for immunogenicity in chimpanzees following intranasal administration. When Ad7-, Ad4-, and Ad5-vectored vaccines were admi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97cd8a5261ded643b0c722593dd32d69
https://doi.org/10.1089/aid.1994.10.1443

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Immunogenicity of Recombinant Human Adenovirus-Human Immunodeficiency Virus Vaccines in Chimpanzees

Autor: Steven K. Vernon, James M. Wilhelm, Mark S. Wade, Pranab K. Chanda, R J Natuk, Shaw-Guang Lee, Shridhara Murthy, Jorg W. Eichberg, Michael D. Lubeck, Krishna K. Murthy, Satoshi Mizutani, Paul P. Hung, Alan R. Davis, Surendra K. Dheer, Murty Chengalvala

Publikováno v: AIDS Research and Human Retroviruses. 9:395-404

Recombinant human adenovirus (Ad) type 4-, 5-, and 7-vectored vaccines expressing either the HIV env or gag-protease genes were tested for immunogenicity in three chimpanzees. The first phase of the vaccination protocol consisted of a primary and two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ad4b2d6e261f3deb62e077c7fe37a9
https://doi.org/10.1089/aid.1993.9.395

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