Life stage-specific glycosylation of extracellular vesicles from Schistosoma mansoni schistosomula and adult worms drives differential interaction with C-type lectin receptors DC-SIGN and MGL

Autor: Marije E. Kuipers, D. Linh Nguyen, Angela van Diepen, Lynn Mes, Erik Bos, Roman I. Koning, Esther N. M. Nolte-’t Hoen, Hermelijn H. Smits, Cornelis H. Hokke

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Schistosomes can survive in mammalian hosts for many years, and this is facilitated by released parasite products that modulate the host’s immune system. Many of these products are glycosylated and interact with host cells via C-type lectin recepto

Externí odkaz: https://doaj.org/article/4a5c7cd49774436ea49d296e83632948

Mass spectrometric and glycan microarray-based characterization of the filarial nematode Brugia malayi glycome reveals anionic and zwitterionic glycan antigens

Autor: Laudine M.C. Petralia, Angela van Diepen, Lena A. Lokker, D. Linh Nguyen, Erliyani Sartono, Vishal Khatri, Ramaswamy Kalyanasundaram, Christopher H. Taron, Jeremy M. Foster, Cornelis H. Hokke

Publikováno v: Molecular and Cellular Proteomics, 21(5). ELSEVIER

Millions of people worldwide are infected with filarial nematodes, responsible for lymphatic filariasis (LF) and other diseases causing chronic disablement. Elimination programs have resulted in a substantial reduction of the rate of infection in cer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98bc99068449aa3e3d7a1c4e0bcf4a6
https://hdl.handle.net/1887/3486060

Generation of glucosylated sn-1-glycerolphosphate teichoic acids

Autor: Johannes Huebner, Gijsbert A. van der Marel, Herman S. Overkleeft, Daan van der Es, Francesca Berni, Angela van Diepen, Ermioni Kalfopoulou, D. Linh Nguyen, Jeroen D. C. Codée, Liming Wang, Cornelis H. Hokke

Publikováno v: RSC Chemical Biology, 2(1), 187-191. ROYAL SOC CHEMISTRY

Lipoteichoic acids (LTAs) have been addressed as possible antigen candidates for vaccine development against several opportunistic Gram-positive pathogens. The study of structure-immunogenicity relationship represents a challenge due to the heterogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6922f5df1a8151545926d5fc85047ff
https://doi.org/10.1039/d0cb00206b

DC-SIGN mediated internalisation of glycosylated extracellular vesicles from Schistosoma mansoni increases activation of monocyte-derived dendritic cells

Autor: Clarize M. de Korne, Marije E. Kuipers, D. Linh Nguyen, Alwin J. van der Ham, John J. Tomes, Roman I. Koning, Esther N. M. Nolte-‘t Hoen, Karl F. Hoffmann, Arifa Ozir-Fazalalikhan, Hermelijn H. Smits, Cornelis H. Hokke

Publikováno v: Journal of Extracellular Vesicles
Journal of Extracellular Vesicles, Vol 9, Iss 1 (2020)
Journal of Extracellular Vesicles, 9(1). Wiley Open Access
Journal of Extracellular Vesicles, 9(1). TAYLOR & FRANCIS LTD

Helminths like Schistosoma mansoni release excretory/secretory (E/S) products that modulate host immunity to enable infection. Extracellular vesicles (EVs) are among these E/S products, yet molecular mechanisms and functionality of S. mansoni EV inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b92032e061aee023f662a4d02cba16
http://europepmc.org/articles/PMC7241508

Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs

Autor: Manfred Wuhrer, Angela van Diepen, Cornelis H. Smit, André M. Deelder, D. Linh Nguyen, Karl F. Hoffmann, Cornelis H. Hokke

Publikováno v: Molecular & Cellular Proteomics, 14, 1750-69
Molecular and Cellular Proteomics, 14, 1750-1769. American Society for Biochemistry and Molecular Biology Inc.
Smit, C H, van Diepen, A, Nguyen, D L, Wuhrer, M, Hoffmann, K F, Deelder, A M & Hokke, C H 2015, ' Glycomic Analysis of Life Stages of the Human Parasite Schistosoma mansoni Reveals Developmental Expression Profiles of Functional and Antigenic Glycan Motifs ', Molecular and Cellular Proteomics, vol. 14, pp. 1750-1769 . https://doi.org/10.1074/mcp.M115.048280
Molecular & Cellular Proteomics, 14, 7, pp. 1750-69
Molecular & Cellular Proteomics : MCP
Molecular and Cellular Proteomics, 14(7), 1750-1769

Contains fulltext : 155377.pdf (Publisher’s version ) (Open Access) Glycans present on glycoproteins and glycolipids of the major human parasite Schistosoma mansoni induce innate as well as adaptive immune responses in the host. To be able to study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4736e5ba59fac0eab916f111c93894bc
http://hdl.handle.net/2066/155377