Zobrazeno 1 - 10
of 74
pro vyhledávání: '"D. Lillian"'
Autor:
Todd D. Lillian
Publikováno v:
Acta Astronautica. 185:140-147
The electric solar wind sail (E-sail) has been proposed as a novel propulsion system that, if successful, promises to facilitate missions that would be inconvenient or impractical with traditional chemical propellants. The most common E-sail concept
Autor:
Saeed Babamohammadi, Todd D. Lillian
Publikováno v:
Biophys J
DNA supercoiling plays an important role in a variety of cellular processes, including transcription, replication, and DNA compaction. To fully understand these processes, we must uncover and characterize the dynamics of supercoiled DNA. However, sup
Publikováno v:
Journal of Oral and Maxillofacial Surgery. 77:e64-e65
Akademický článek
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Autor:
Noel C. Perkins, Troy A. Lionberger, Maryna Taranova, Todd D. Lillian, Ioan Andricioaei, Andrew D. Hirsh
Publikováno v:
Biophysical Journal. 104(9):2058-2067
In the bacteriophage ϕ29, DNA is packed into a preassembled capsid from which it ejects under high pressure. A recent cryo-EM reconstruction of ϕ29 revealed a compact toroidal DNA structure (30–40 basepairs) lodged within the exit cavity formed b
Autor:
Edgar Meyhofer, Guillaume Witz, Julien Dorier, Davide Demurtas, Andrzej Stasiak, Todd D. Lillian, Troy A. Lionberger
Publikováno v:
Nucleic Acids Research
Nucleic acids research
Nucleic Acids Research, vol. 39, no. 22, pp. 9820-9832
Nucleic acids research
Nucleic Acids Research, vol. 39, no. 22, pp. 9820-9832
In cells, DNA is routinely subjected to significant levels of bending and twisting. In some cases, such as under physiological levels of supercoiling, DNA can be so highly strained, that it transitions into non-canonical structural conformations that
Publikováno v:
Biophysical Journal. 101(3):718-726
Protein-mediated DNA looping, such as that induced by the lactose repressor (LacI) of Escherichia coli, is a well-known gene regulation mechanism. Although researchers have given considerable attention to DNA looping by LacI, many unanswered question
Publikováno v:
Biophysical Journal. 95:5832-5842
Sequence-dependent intrinsic curvature of DNA influences looping by regulatory proteins such as LacI and NtrC. Curvature can enhance stability and control shape, as observed in LacI loops formed with three designed sequences with operators bracketing
Autor:
Todd D. Lillian, Edgar Meyhofer, Sachin Goyal, Jens-Christian Meiners, Seth Blumberg, Noel C. Perkins
Publikováno v:
Biophysical Journal. 93:4342-4359
Protein-mediated DNA looping is a common mechanism for regulating gene expression. Loops occur when a protein binds to two operators on the same DNA molecule. The probability of looping is controlled, in part, by the basepair sequence of inter-operat
Autor:
Todd D. Lillian, Ikenna D. Ivenso
Publikováno v:
Biophysical journal. 110(10)
Several recent single-molecule experiments observe the response of supercoiled DNA to nicking endonucleases and topoisomerases. Typically in these experiments, indirect measurements of supercoil relaxation are obtained by observing the motion of a la