Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane

Autor: Adrián González-López, Daniel S. D. Larsson, Ravi Kiran Koripella, Brett N. Cain, Martin Garcia Chavez, Paul J. Hergenrother, Suparna Sanyal, Maria Selmer

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract The antibiotic fusidic acid (FA) is used to treat Staphylococcus aureus infections. It inhibits protein synthesis by binding to elongation factor G (EF-G) and preventing its release from the ribosome after translocation. While FA, due to per

Externí odkaz: https://doaj.org/article/688e7a88add545d890d90508e053347f

Structural Consequences of Deproteinating the 50S Ribosome

Autor: Daniel S. D. Larsson, Sandesh Kanchugal P, Maria Selmer

Publikováno v: Biomolecules, Vol 12, Iss 11, p 1605 (2022)

Ribosomes are complex ribonucleoprotein particles. Purified 50S ribosomes subjected to high-salt wash, removing a subset of ribosomal proteins (r-proteins), were shown as competent for in vitro assembly into functional 50S subunits. Here, we used cry

Externí odkaz: https://doaj.org/article/98100d211cf44661a8bbafde6374e904

Considerations for three-dimensional image reconstruction from experimental data in coherent diffractive imaging

Autor: Ida V. Lundholm, Jonas A. Sellberg, Tomas Ekeberg, Max F. Hantke, Kenta Okamoto, Gijs van der Schot, Jakob Andreasson, Anton Barty, Johan Bielecki, Petr Bruza, Max Bucher, Sebastian Carron, Benedikt J. Daurer, Ken Ferguson, Dirk Hasse, Jacek Krzywinski, Daniel S. D. Larsson, Andrew Morgan, Kerstin Mühlig, Maria Müller, Carl Nettelblad, Alberto Pietrini, Hemanth K. N. Reddy, Daniela Rupp, Mario Sauppe, Marvin Seibert, Martin Svenda, Michelle Swiggers, Nicusor Timneanu, Anatoli Ulmer, Daniel Westphal, Garth Williams, Alessandro Zani, Gyula Faigel, Henry N. Chapman, Thomas Möller, Christoph Bostedt, Janos Hajdu, Tais Gorkhover, Filipe R. N. C. Maia

Publikováno v: IUCrJ, Vol 5, Iss 5, Pp 531-541 (2018)

Diffraction before destruction using X-ray free-electron lasers (XFELs) has the potential to determine radiation-damage-free structures without the need for crystallization. This article presents the three-dimensional reconstruction of the Melbournev

Externí odkaz: https://doaj.org/article/f9f24d9a5b9b428587c782e2035a0d30

The OpenMolcas Web: A Community-Driven Approach to Advancing Computational Chemistry

Autor: Giovanni Li Manni, Ignacio Fdez. Galván, Ali Alavi, Flavia Aleotti, Francesco Aquilante, Jochen Autschbach, Davide Avagliano, Alberto Baiardi, Jie J. Bao, Stefano Battaglia, Letitia Birnoschi, Alejandro Blanco-González, Sergey I. Bokarev, Ria Broer, Roberto Cacciari, Paul B. Calio, Rebecca K. Carlson, Rafael Carvalho Couto, Luis Cerdán, Liviu F. Chibotaru, Nicholas F. Chilton, Jonathan Richard Church, Irene Conti, Sonia Coriani, Juliana Cuéllar-Zuquin, Razan E. Daoud, Nike Dattani, Piero Decleva, Coen de Graaf, Mickaël G. Delcey, Luca De Vico, Werner Dobrautz, Sijia S. Dong, Rulin Feng, Nicolas Ferré, Michael Filatov(Gulak), Laura Gagliardi, Marco Garavelli, Leticia González, Yafu Guan, Meiyuan Guo, Matthew R. Hennefarth, Matthew R. Hermes, Chad E. Hoyer, Miquel Huix-Rotllant, Vishal Kumar Jaiswal, Andy Kaiser, Danil S. Kaliakin, Marjan Khamesian, Daniel S. King, Vladislav Kochetov, Marek Krośnicki, Arpit Arun Kumaar, Ernst D. Larsson, Susi Lehtola, Marie-Bernadette Lepetit, Hans Lischka, Pablo López Ríos, Marcus Lundberg, Dongxia Ma, Sebastian Mai, Philipp Marquetand, Isabella C. D. Merritt, Francesco Montorsi, Maximilian Mörchen, Artur Nenov, Vu Ha Anh Nguyen, Yoshio Nishimoto, Meagan S. Oakley, Massimo Olivucci, Markus Oppel, Daniele Padula, Riddhish Pandharkar, Quan Manh Phung, Felix Plasser, Gerardo Raggi, Elisa Rebolini, Markus Reiher, Ivan Rivalta, Daniel Roca-Sanjuán, Thies Romig, Arta Anushirwan Safari, Aitor Sánchez-Mansilla, Andrew M. Sand, Igor Schapiro, Thais R. Scott, Javier Segarra-Martí, Francesco Segatta, Dumitru-Claudiu Sergentu, Prachi Sharma, Ron Shepard, Yinan Shu, Jakob K. Staab, Tjerk P. Straatsma, Lasse Kragh Sørensen, Bruno Nunes Cabral Tenorio, Donald G. Truhlar, Liviu Ungur, Morgane Vacher, Valera Veryazov, Torben Arne Voß, Oskar Weser, Dihua Wu, Xuchun Yang, David Yarkony, Chen Zhou, J. Patrick Zobel, Roland Lindh

Publikováno v: Journal of Chemical Theory and Computation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5c743fdd0f7bf1fbaab9b764bafcf81
https://doi.org/10.1021/acs.jctc.3c00182

Coherent diffraction of single Rice Dwarf virus particles using hard X-rays at the Linac Coherent Light Source

Autor: Ahmad Hosseinizadeh, Chun Hong Yoon, Peter Schwander, Henry N. Chapman, Adrian P. Mancuso, M. Marvin Seibert, Hasan DeMirci, Akifumi Higashiura, Max F. Hantke, Benedikt J. Daurer, Richard Bean, Ti-Yen Lan, Atsushi Nakagawa, Richard A. Kirian, Daniel Westphal, Jakob Andreasson, N. Duane Loh, Kenta Okamoto, Max Rose, Petra Fromme, Daniel S. D. Larsson, Haiguang Liu, Veit Elser, Raymond G. Sierra, Kerstin Mühlig, Andrew Aquila, Yoonhee Kim, Daewoong Nam, Kartik Ayyer, Gijs van der Schot, Changyong Song, James Zook, Sébastien Boutet, Garth J. Williams, Ivan A. Vartanyants, Martin Svenda, Johan Bielecki, Garrett Nelson, Brenda G. Hogue, Peter Berntsen, Janos Hajdu, Max O. Wiedorn, Anna Munke, Salah Awel, Anton Barty, Jonas A. Sellberg, Hemanth K. N. Reddy, Carl Nettelblad, Nicusor Timneanu, Maximilian Bucher, Abbas Ourmazd, Filipe R. N. C. Maia, Paulraj Lourdu Xavier

Publikováno v: Scientific Data
Scientific data 3, 160064-(2016). doi:10.1038/sdata.2016.64

Scientific data 3, 160064 -(2016). doi:10.1038/sdata.2016.64
Single particle diffractive imaging data from Rice Dwarf Virus (RDV) were recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS). RDV was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f375cedf151da0f02098a6c8417c0359