Zobrazeno 1 - 10
of 510
pro vyhledávání: '"D. LITTLEJOHN"'
Autor:
Mohammad Ghoreishifar, Amanda J. Chamberlain, Ruidong Xiang, Claire P. Prowse-Wilkins, Thomas J. Lopdell, Mathew D. Littlejohn, Jennie E. Pryce, Michael E. Goddard
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-11 (2024)
Abstract Background Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by certain histone modifications. These variants are believed to influence gen
Externí odkaz:
https://doaj.org/article/909bbb2cefc147078721ba74bc8405dd
Autor:
Thomas J. Lopdell, Alexander J. Trevarton, Janelle Moody, Claire Prowse-Wilkins, Sarah Knowles, Kathryn Tiplady, Amanda J. Chamberlain, Michael E. Goddard, Richard J. Spelman, Klaus Lehnert, Russell G. Snell, Stephen R. Davis, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Bovine lactoferrin (Lf) is an iron absorbing whey protein with antibacterial, antiviral, and antifungal activity. Lactoferrin is economically valuable and has an extremely variable concentration in milk, partly driven by environme
Externí odkaz:
https://doaj.org/article/8080a82b88cf4f85b058bde3a2e3767d
Autor:
Claire P. Prowse-Wilkins, Thomas J. Lopdell, Ruidong Xiang, Christy J. Vander Jagt, Mathew D. Littlejohn, Amanda J. Chamberlain, Michael E. Goddard
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background Causal variants for complex traits, such as eQTL are often found in non-coding regions of the genome, where they are hypothesised to influence phenotypes by regulating gene expression. Many regulatory regions are marked by histone
Externí odkaz:
https://doaj.org/article/bc8d9d89f6eb439bb8e78fb640312239
Autor:
Kathryn M. Tiplady, Thomas J. Lopdell, Richard G. Sherlock, Thomas J.J. Johnson, Richard J. Spelman, Bevin L. Harris, Stephen R. Davis, Mathew D. Littlejohn, Dorian J. Garrick
Publikováno v:
Journal of Dairy Science, Vol 105, Iss 12, Pp 9763-9791 (2022)
ABSTRACT: Fourier-transform mid-infrared (FT-MIR) spectroscopy is a high-throughput and inexpensive methodology used to evaluate concentrations of fat and protein in dairy cattle milk samples. The objective of this study was to compare the genetic ch
Externí odkaz:
https://doaj.org/article/87ad00ec3d594691b9978de5dc621ff2
Autor:
Stephen R. Davis, Hamish E. Ward, Van Kelly, David Palmer, Alexandra E. Ankersmit-Udy, Thomas J. Lopdell, Sarah D. Berry, Mathew D. Littlejohn, Kathryn Tiplady, Linda F. Adams, Katie Carnie, Alayna Burrett, Natalie Thomas, Russell G. Snell, Richard J. Spelman, Klaus Lehnert
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-11 (2022)
Abstract Background Milk samples from 10,641 dairy cattle were screened by a mass spectrometry method for extreme concentrations of the A or B isoforms of the whey protein, β-lactoglobulin (BLG), to identify causative genetic variation driving chang
Externí odkaz:
https://doaj.org/article/460d3305b076430b8ce7ce75746098c0
Autor:
Andrew Jiang, Alex Ankersmit-Udy, Sally-Anne Turner, Megan Scholtens, Mathew D. Littlejohn, Nicolas Lopez-Villalobos, Colin G. Proser, Russell G. Snell, Klaus Lehnert
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-10 (2022)
Abstract Background Economically important milk production traits including milk volume, milk fat and protein yield vary considerably across dairy goats in New Zealand. A significant portion of the variation is attributable to genetic variation. Disc
Externí odkaz:
https://doaj.org/article/37111db90e9f4fd280d879d1c31e449d
Autor:
Edwardo G. M. Reynolds, Thomas Lopdell, Yu Wang, Kathryn M. Tiplady, Chad S. Harland, Thomas J. J. Johnson, Catherine Neeley, Katie Carnie, Richard G. Sherlock, Christine Couldrey, Stephen R. Davis, Bevin L. Harris, Richard J. Spelman, Dorian J. Garrick, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-16 (2022)
Abstract Background Deleterious recessive conditions have been primarily studied in the context of Mendelian diseases. Recently, several deleterious recessive mutations with large effects were discovered via non-additive genome-wide association studi
Externí odkaz:
https://doaj.org/article/c6d74fe902814b03a9b570eab1034eda
Autor:
G. Laible, S.-A. Cole, B. Brophy, J. Wei, S. Leath, S. Jivanji, M. D. Littlejohn, D. N. Wells
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Background High-producing Holstein Friesian dairy cattle have a characteristic black and white coat, often with large proportions of black. Compared to a light coat color, black absorbs more solar radiation which is a contributing factor to
Externí odkaz:
https://doaj.org/article/2cf4f1bd516745a0891129aeb0a93e40
Autor:
Kathryn M. Tiplady, Thomas J. Lopdell, Edwardo Reynolds, Richard G. Sherlock, Michael Keehan, Thomas JJ. Johnson, Jennie E. Pryce, Stephen R. Davis, Richard J. Spelman, Bevin L. Harris, Dorian J. Garrick, Mathew D. Littlejohn
Publikováno v:
Genetics Selection Evolution, Vol 53, Iss 1, Pp 1-24 (2021)
Abstract Background Fourier-transform mid-infrared (FT-MIR) spectroscopy provides a high-throughput and inexpensive method for predicting milk composition and other novel traits from milk samples. While there have been many genome-wide association st
Externí odkaz:
https://doaj.org/article/3741a0b431e24b8783c25e8d5cfc1f73
Autor:
Tania Fink, Thomas J. Lopdell, Kathryn Tiplady, Renee Handley, Thomas J. J. Johnson, Richard J. Spelman, Stephen R. Davis, Russell G. Snell, Mathew D. Littlejohn
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition
Externí odkaz:
https://doaj.org/article/c12b3a625ee1495d8ea1c2bf4fc75c90