Výsledky vyhledávání

Remote glucosyltransferase-microparticle vaccine delivery induces protective immunity in the oral cavity

Autor: D J, Smith, A, Lam, L A, Barnes, W F, King, Z, Peacock, D L, Wise, D J, Trantolo, M A, Taubman

Publikováno v: Oral microbiology and immunology. 18(4)

Intranasally administered dental caries vaccines show significant promise for human application. Alternate mucosal routes may be required, however, to induce caries-protective salivary IgA antibody in children with respiratory diseases. Since rectal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcf9a4d36dae81ce3a235477ae9645bf
https://pubmed.ncbi.nlm.nih.gov/12823800

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Mechanical evaluation of a porous bone graft substitute based on poly(propylene glycol-co-fumaric acid)

Autor: David D. Hile, J. McCool, Debra J. Trantolo, Carl A. Kirker-Head, Michael P. Kowaleski, Stephen A. Doherty, D L Wise

Publikováno v: Journal of biomedical materials research. Part B, Applied biomaterials. 66(1)

A porous, resorbable polymer composite based on poly(propylene glycol-co-fumaric acid) (PPF) was mechanically evaluated in vitro for use as a bone graft substitute and fracture fixative. The test material created a dynamic system capable of initially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b29a7a2a1ae3d687afd7b315273202
https://pubmed.ncbi.nlm.nih.gov/12808589

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Induction of secretory immunity with bioadhesive poly (D,L-lactide-co-glycolide) microparticles containing Streptococcus sobrinus glucosyltransferase

Autor: D J, Smith, D J, Trantolo, W F, King, E J, Gusek, P H, Fackler, J D, Gresser, V L, De Souza, D L, Wise

Publikováno v: Oral microbiology and immunology. 15(2)

The effect of mucosal delivery of Streptococcus sobrinus glucosyltransferase (GTF) in bioadhesive poly (D,L-lactide-co-glycolide) (PLGA) microparticles on induction of salivary IgA and serum IgG antibody responses was measured in Sprague-Dawley rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a2fd7af045d0628b3073f14de83a2eb
https://pubmed.ncbi.nlm.nih.gov/11155176

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High strength bioresorbable bone plates: preparation, mechanical properties and in vitro analysis

Autor: V, Hasirci, K U, Lewandrowski, S P, Bondre, J D, Gresser, D J, Trantolo, D L, Wise

Publikováno v: Bio-medical materials and engineering. 10(1)

Biodegradable bone plates were prepared as semi-interpenetrating networks (SIPN) of crosslinked polypropylene fumarate (PPF) within a host matrix of either poly(lactide-co-glycolide)-85:15 (PLGA) or poly(1-lactide-co-d,l-lactide)-70:30 (PLA) using N-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b681a6395c105b12e2ea70dbac0f8dd3
https://pubmed.ncbi.nlm.nih.gov/10950204

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Improved osteoconduction of cortical bone grafts by biodegradable foam coating

Autor: K U, Lewandrowski, S P, Bondre, J D, Gresser, D L, Wise, W W, Tomford, D J, Trantolo

Publikováno v: Bio-medical materials and engineering. 9(5-6)

Alteration of the geometrical surface configuration of cortical bone allografts may improve incorporation into host bone. A porous biodegradable coating that would maintain immediate structural recovery and subsequently allow normal graft healing and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c3896c48196e1f25c730579ca599fed
https://pubmed.ncbi.nlm.nih.gov/10822482

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Augmentation of osteoinduction with a biodegradable poly(propylene glycol-co-fumaric acid) bone graft extender. A histologic and histomorphometric study in rats

Autor: K U, Lewandrowski, S, Bondre, J D, Gresser, A E, Silva, D L, Wise, D J, Trantolo

Publikováno v: Bio-medical materials and engineering. 9(5-6)

We investigated the feasibility of enhancing the regeneration of skeletal tissues by augmenting bone grafts with a composite biodegradable bone graft extender material based on the polymer poly(propylene fumarate), PPF. The material was mixed with au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f353d4ca830ec7a2425d9d891a46acdf
https://pubmed.ncbi.nlm.nih.gov/10822488

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Chemotherapy of tuberculosis in mice using single implants of isoniazid and pyrazinamide

Autor: P R, Gangadharam, N, Geeta, Y Y, Hsu, D L, Wise

Publikováno v: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 3(6)

To establish the chemotherapeutic value of a depot drug preparation of isoniazid and pyrazinamide against experimental tuberculosis.To see whether sustained levels of pyrazinamide are available for prolonged periods after a single subcutaneous admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebfc92498c8a388ee9a29303a833116d
https://pubmed.ncbi.nlm.nih.gov/10383065

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Effect of polymer foam morphology and density on kinetics of in vitro controlled release of isoniazid from compressed foam matrices

Autor: Y Y, Hsu, J D, Gresser, D J, Trantolo, C M, Lyons, P R, Gangadharam, D L, Wise

Publikováno v: Journal of biomedical materials research. 35(1)

The purpose of this study was to compare the effect of polymer foam morphology and density prior to compaction on the kinetics of isoniazid (INH) release from the final high-density extruded matrices. The feasibility of preparing low density foams of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8fd31c2c14ba2f2cc88fc6dc4f62a4e
https://pubmed.ncbi.nlm.nih.gov/9104703

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