Zobrazeno 1 - 10 of 28 pro vyhledávání: '"D. L. Severson"'
1
Modulation of potassium currents by angiotensin and oxidative stress in cardiac cells from the diabetic rat
Autor: Y, Shimoni, D, Hunt, M, Chuang, K Y, Chen, G, Kargacin, D L, Severson
Publikováno v: The Journal of physiology. 567(Pt 1)
Diabetes induces oxidative stress and leads to attenuation of cardiac K+ currents. We investigated the role of superoxide ions and angiotensin II (ANG II) in generating and linking oxidative stress to the modulation of K+ currents under diabetic cond
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::22b62e2d5bf3b15e11fad6c7315ea2cf
https://pubmed.ncbi.nlm.nih.gov/15946965
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3
Lipoprotein lipase activity is stimulated by insulin and dexamethasone in cardiomyocytes from diabetic rats
Autor: H S, Ewart, R, Carroll, D L, Severson
Publikováno v: Canadian journal of physiology and pharmacology. 77(8)
Type 1 diabetes mellitus reduces lipoprotein lipase (LPL) activity in the heart. The diabetic phenotype of decreased LPL activity in freshly isolated cardiomyocytes persisted after overnight culture (16 h). Total cellular LPL activity was 311+/-56 nm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d74ded79b0efb71c3ce6b585d665538b
https://pubmed.ncbi.nlm.nih.gov/10543720
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4
Insulin and dexamethasone stimulation of cardiac lipoprotein lipase activity involves the actin-based cytoskeleton
Autor: H S, Ewart, D L, Severson
Publikováno v: The Biochemical journal. 340
Lipoprotein lipase (LPL) activity in cultured ventricular cardiomyocytes from adult rat hearts was stimulated by the combination of insulin (100 nM) and dexamethasone (100 nM) during an overnight (16 h) incubation. Wortmannin (100 nM), rapamycin (30
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b969ba3301069cd0560149c4fb65de0
https://pubmed.ncbi.nlm.nih.gov/10333493
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5
Heparin-releasable lipoprotein lipase activity is increased in cardiomyocytes after culture
Autor: L G, Anderson, R, Carroll, A, Acharya, D L, Severson
Publikováno v: Canadian journal of physiology and pharmacology. 76(2)
The activity of lipoprotein lipase (LPL) in adult rat heart cardiomyocytes after overnight culture on laminin-coated plates for 18-22 h was compared with enzyme activity in freshly isolated cardiomyocytes. LPL activity in cellular homogenates from cu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f7db55256179e1069ff37775fd4b126
https://pubmed.ncbi.nlm.nih.gov/9635164
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6
Endothelial binding sites for lipoprotein lipase are not diminished in perfused hearts from diabetic rats
Autor: L, Liu, D L, Severson
Publikováno v: Canadian journal of physiology and pharmacology. 74(11)
The possibility that diabetes reduces functional, heparin-releasable lipoprotein lipase (HR-LPL) activity on the coronary vasculature of perfused hearts by altering endothelial binding sites for the enzyme was examined by measuring the binding and su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9188507ea5ff50274f313860625e158
https://pubmed.ncbi.nlm.nih.gov/9028578
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7
Diacylglycerols derived from membrane phospholipids are metabolized by lipases in A10 smooth muscle cells
Autor: I. Migas, D. L. Severson
Publikováno v: The American journal of physiology. 271(4 Pt 1)
The metabolic fate of endogenous diacylglycerol (DAG) in cultured A10 smooth muscle cells was determined. Preincubation of A10 cells with [3H]myristic acid or [3H]arachidonic acid resulted in preferential labeling of phosphatidylcholine (PC) or phosp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93dfc3715f30dff620c510cb1db5af7
https://pubmed.ncbi.nlm.nih.gov/8897825
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8
Signal transduction in vascular smooth muscle: diacylglycerol second messengers and PKC action
Autor: M. W. Lee, D. L. Severson
Publikováno v: The American journal of physiology. 267(3 Pt 1)
Agonist-stimulated phospholipid turnover can generate diacylglycerol (DAG), an intracellular second messenger that activates protein kinase C (PKC). DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1659e8e7b20ddd70a21427e8a0c26722
https://pubmed.ncbi.nlm.nih.gov/7943196
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9
Metabolism of a long-chain diacylglycerol by permeabilized A10 smooth muscle cells
Autor: M. Chuang, D. L. Severson, M. W. Lee, Dayuan Zhao
Publikováno v: The American journal of physiology. 265(4 Pt 1)
The regulatory effects of diacylglycerol (DAG) second messengers will be terminated by metabolism. A long-chain DAG, 1-palmitoyl-2-[1-14C]oleoyl-sn-glycerol (2-[14C]POG), was metabolized by cultured A10 smooth muscle cells after permeabilization by p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0cf1c9fc31777aa865b9d09c1247bfd
https://pubmed.ncbi.nlm.nih.gov/8238317
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10
Apolipoprotein VLDL-II inhibits lipolysis of triglyceride-rich lipoproteins in the laying hen
Autor: W J, Schneider, R, Carroll, D L, Severson, J, Nimpf
Publikováno v: Journal of lipid research. 31(3)
In the laying hen, very low density lipoprotein (VLDL) particles contain large amounts of apolipoprotein (apo)-VLDL-II in addition to apoB. These triglyceride-rich lipoproteins are transported from the liver primarily to growing oocytes. Since no app
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::61c3115395c1ee4f093e46682ddab935
https://pubmed.ncbi.nlm.nih.gov/2111369
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