Zobrazeno 1 - 10
of 36
pro vyhledávání: '"D. L. Sean McElwain"'
Autor:
Stuart T. Johnston, Matthew J. Simpson, D. L. Sean McElwain, Benjamin J. Binder, Joshua V. Ross
Publikováno v:
Open Biology, Vol 4, Iss 9 (2014)
Quantifying the impact of biochemical compounds on collective cell spreading is an essential element of drug design, with various applications including developing treatments for chronic wounds and cancer. Scratch assays are a technically simple and
Externí odkaz:
https://doaj.org/article/60031551c0674215bf022b672248e49a
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85488 (2014)
Most mathematical models of collective cell spreading make the standard assumption that the cell diffusivity and cell proliferation rate are constants that do not vary across the cell population. Here we present a combined experimental and mathematic
Externí odkaz:
https://doaj.org/article/cf1d655838374989b939ea56223e471b
Autor:
D. L. Sean McElwain, Alexander P Browning, Jacqui A. McGovern, Parvathi Haridas, Matthew J. Simpson
Publikováno v:
BMC Systems Biology, Vol 12, Iss 1, Pp 1-15 (2018)
BMC Systems Biology
BMC Systems Biology
BackgroundMelanoma can be diagnosed by identifying nests of cells on the skin surface. Understanding the processes that drive nest formation is important as these processes could be potential targets for new cancer drugs. Cell proliferation and cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77568ca205321bd228520ce5af3d579b
http://link.springer.com/article/10.1186/s12918-018-0559-9
http://link.springer.com/article/10.1186/s12918-018-0559-9
Autor:
Helen M. Byrne, Jennifer A. Flegg, D. L. Sean McElwain, Philip K. Maini, Chathranee Jayathilake, Harriet W. Hopf, Mark B. Flegg
Infections are a common complication of any surgery, often requiring a recovery period in hospital. Supplemental oxygen therapy administered during and immediately after surgery is thought to enhance the immune response to bacterial contamination. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0eaec34c06776dc2870a65190082539
https://ora.ox.ac.uk/objects/uuid:f9ab3a2f-498c-4ddc-acb5-4cdf68cee79c
https://ora.ox.ac.uk/objects/uuid:f9ab3a2f-498c-4ddc-acb5-4cdf68cee79c
Autor:
D. L. Sean McElwain, Joshua V. Ross, Benjamin J. Binder, Parvathi Haridas, Stuart T. Johnston, Matthew J. Simpson
Publikováno v:
Journal of Theoretical Biology. 400:19-31
Scratch assays are often used to investigate potential drug treatments for chronic wounds and cancer. Interpreting these experiments with a mathematical model allows us to estimate the cell diffusivity, D, and the cell proliferation rate, λ. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299f61a711834e4c578ee5fc6af03f51
https://doi.org/10.1016/j.jtbi.2016.04.012
https://doi.org/10.1016/j.jtbi.2016.04.012
Autor:
Parvathi Haridas, Jacqui A. McGovern, Catherine J. Penington, D. L. Sean McElwain, Matthew J. Simpson
Malignant spreading involves the migration of cancer cells amongst other native cell types. For example, in vivo melanoma invasion involves individual melanoma cells migrating through native skin, which is composed of several distinct subpopulations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaa27c3284c8afca862594183c6b17b
We present an approach for computing extensions of velocities or other fields in level set methods by solving a biharmonic equation. The approach differs from other commonly used approaches to velocity extension because it deals with the interface fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fd56a3d20553253d7f36c11c43ba86
The mechanical behaviour of solid biological tissues has long been described using models based on classical continuum mechanics. However, the classical continuum theories of elasticity and viscoelasticity cannot easily capture the continual remodell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8c70890ec3f402cad4a33412131b17
Publikováno v:
Journal of Theoretical Biology. 356:71-84
Cells respond to various biochemical and physical cues during wound-healing and tumour progression. in vitro assays used to study these processes are typically conducted in one particular geometry and it is unclear how the assay geometry affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec99263ea031826967e2e1775f635a0
Publikováno v:
Scientific Reports
Invasion processes are ubiquitous throughout cell biology and ecology. During invasion, individuals can become isolated from the bulk population and behave differently. We present a discrete, exclusion-based description of the birth, death and moveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967f4b77092975d7ef2e6b903f69a5c1