Výsledky vyhledávání - "D. L. SPRINGER"

The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects

Autor: Charles W. Francis, Neil Blumberg, J. J. O'Brien, D. L. Springer, Richard P. Phipps, S. Bancos, Sherry L. Spinelli, G. M. Lehmann, Mark B. Taubman

Publikováno v: PPAR Research, Vol 2008 (2008)
PPAR Research

Historically, platelets were viewed as simple anucleate cells responsible for initiating thrombosis and maintaining hemostasis, but clearly they are also key mediators of inflammation and immune cell activation. An emerging body of evidence links pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f2a5279bbb389cd64b60332a176fc7
https://doi.org/10.1155/2008/328172

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Effect of calcium channel antagonists nifedipine and nicardipine on rat cytochrome P-450 2B and 3A forms

Autor: R C, Zangar, J R, Okita, H, Kim, P E, Thomas, A, Anderson, R J, Edwards, D L, Springer, R T, Okita

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(3)

Calcium channel antagonists are widely prescribed for treatment of hypertension. In this study, we examined whether treatment with the calcium channel antagonists, nicardipine, nifedipine or diltiazem, alters cytochrome P-450 2B or 3A (CYP2B or CYP3A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46d2483f63881e57d3819a3a038fc6a5
https://pubmed.ncbi.nlm.nih.gov/10454523

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Enterohepatic recirculation of trichloroethanol glucuronide as a significant source of trichloroacetic acid. Metabolites of trichloroethylene

Autor: R D, Stenner, J L, Merdink, D K, Stevens, D L, Springer, R J, Bull

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(5)

Trichloroacetic acid (TCA) is a metabolite of trichloroethylene (TRI) thought to contribute to its hepatocarcinogenic effects in mice. Recent studies have shown that peak blood concentrations of TCA do not occur until approximately 12 hr after an ora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b2bcb21bb931c9f76085cc6892af1b0
https://pubmed.ncbi.nlm.nih.gov/9152590

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Analysis of radiation induced nucleobase-peptide crosslinks by electrospray ionization mass spectrometry

Autor: M S, Lipton, A L, Fuciarelli, D L, Springer, S A, Hofstadler, C G, Edmonds

Publikováno v: Rapid communications in mass spectrometry : RCM. 11(15)

Upon exposure to ionizing radiation, DNA undergoes a variety of modifications including the production of a covalent bond between the nucleobase thymine and the amino acid tyrosine. These crosslinked lesions, produced in cells exposed to ionizing rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a69b3b10c3f83b975033d5b4d8f6766
https://pubmed.ncbi.nlm.nih.gov/9364796

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Characterization of radiation-induced thymine-tyrosine crosslinks by electrospray ionization mass spectrometry

Autor: M S, Weir Lipton, A F, Fuciarelli, D L, Springer, C G, Edmonds

Publikováno v: Radiation research. 145(6)

Exposure to ionizing radiation leads to formation of covalent crosslinks between DNA and proteins. The nature, extent and site of the modifications are not well understood due to the difficulty in assessing free radical-induced damage in biopolymers.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9be25a5210a1cdf94ba2a4f868693f6d
https://pubmed.ncbi.nlm.nih.gov/8643827

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Cardiovascular Effects in Rats following Exposure to a High-Boiling Coal Liquid

Autor: R. C. ZANGAR, L. B. SASSER, D. D. MAHLUM, R. H. ABHOLD, D. L. SPRINGER

Publikováno v: Toxicological Sciences. 9:659-667

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0158fda712dea85a4d026fbc1fc86a4a
https://doi.org/10.1093/toxsci/9.4.659

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Magnitude corrections for attenuation in the upper mantle

Autor: P. D. Marshall, H. C. Rodean, D. L. Springer

Publikováno v: Geophysical Journal International. 57:609-637

Summary. The mb:Ms relation for explosions at the Nevada Test Site (NTS) differs from those for explosions in other parts of the world. There is considerable evidence that this results mostly from high body-wave attenuation in the upper mantle beneat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c06a4ba1a18d870c910799f120acaeb
https://doi.org/10.1111/j.1365-246x.1979.tb06781.x

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