Výsledky vyhledávání - "D. L. P. Rees"

In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase

Autor: FJ Gonzalez, D. L. P. Rees, John O. Miners, Maurice E. Veronese, DJ Birkett, Tommy B. Andersson

Publikováno v: British Journal of Clinical Pharmacology. 37:413-420

1. The activation of proguanil to cycloguanil by human liver microsomes was studied to define the cytochrome P450 (CYP) isoforms involved in this reaction. 2. Apparent Km values for proguanil ranged from 35 microM to 183 microM with microsomes from f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ffa0e0c396ea8303c5e9e542f5b5c3
https://doi.org/10.1111/j.1365-2125.1994.tb05707.x

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Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

Autor: R. Gasser, John O. Miners, U. A. Meyer, Maurice E. Veronese, Peter I. Mackenzie, Donald J. Birkett, D. L. P. Rees, C. J. Doecke, Michael E. McManus

Publikováno v: Biochemical Journal. 289:533-538

Evidence from human studies in vivo and in vitro strongly suggests that the methylhydroxylation of tolbutamide and the 4-hydroxylation of phenytoin, the major pathways in the elimination of these two drugs, are catalysed by the same cytochrome P-450

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7092bd29713095414092ca244734af77
https://doi.org/10.1042/bj2890533

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Eskornade in the Treatment of Diurnal Incontinence in Children

Autor: D. L. P. Rees, P. G. Ransley

Publikováno v: British Journal of Urology. 52:476-479

Summary— This study examined 75 children with daytime wetting and particularly those with some form of bladder neck incompetence. There was a good response in 75% of cases to Eskornade (containing phenylpropanolamine, an α adrenergic agonist), but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2063186fe8a8122aafbfc969ed37849
https://doi.org/10.1111/j.1464-410x.1980.tb03094.x

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Psychiatric aspects of recurrent cystitis in women

Autor: D. L. P. Rees, N. Farhoumand

Publikováno v: British journal of urology. 49(7)

Using both psychometric questionnaires and psychiatric interview it has been shown that women with recurrent cystitis have significantly more psychiatric symptoms (particularly those of anxiety) than the population as a whole. By comparison with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e8df0baeca2f1b5a2ef01f74ac75ca
https://pubmed.ncbi.nlm.nih.gov/597703

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Urodynamic findings in adult females with frequency and dysuria

Autor: M. E. Mayo, J. E. A. Wickham, D. L. P. Rees, P. T. Doyle, A. K. M. S. Islam, H. N. Whitfield

Publikováno v: British journal of urology. 47(7)

Summary Urodynamic findings, and in particular measures of outflow obstruction in a consecutive series of 156 women presenting with recurrent increased frequency and dysuria, have been analysed. Poor correlation between these various measures has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71113796f7a38565770ec817df6bee02
https://pubmed.ncbi.nlm.nih.gov/1241333

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Bladder instability in women with recurrent cystitis

Autor: J. E. A. Wickham, H. N. Whitfield, D. L. P. Rees

Publikováno v: British journal of urology. 50(7)

Summary— Factors in the aetiology of bladder instability in women with recurrent cystitis are analysed. A multifactorial approach to patient management is advocated and supported by a treatment failure rate of only 3.6% with these patients over a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bf3b05fb17b49cfd6947d87c0e20a9
https://pubmed.ncbi.nlm.nih.gov/753505

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