Zobrazeno 1 - 10
of 25
pro vyhledávání: '"D. L. Keefe"'
Publikováno v:
Minerva medica. 100(5)
The lifetime risks for both breast and ovarian cancer for BRCA mutation carriers far exceeds the general population risk of 13% for breast cancer and 1.4% for ovarian cancer. BRCA carriers have unique and medically complicated decisions to make regar
Publikováno v:
Cellular and molecular life sciences : CMLS. 64(2)
Meiotic dysfunction increasingly afflicts women as they age, resulting in infertility, miscarriage and handicapped offspring. How aging disrupts meiotic function in women remains unclear, but as women increasingly delay childbearing, this issue becom
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 91(4)
To determine sex differences in osmoregulation of arginine vasopressin (AVP) and body water, we studied eight men (24 +/- 1 yr) and eight women (29 +/- 2 yr) during 3% NaCl infusion [hypertonic saline infusion (HSI); 120 min, 0.1 ml. kg body wt(-1).
Autor:
D L, Keefe
Publikováno v:
Seminars in oncology. 28(4 Suppl 12)
The highly active chemotherapeutic agents doxorubicin, duanorubicin, idarubicin, epirubicin, and mitoxantrone are also associated with acute, largely reversible cardiotoxic effects and a dose-related cardiomyopathy. This cardiomyopathy is characteriz
Publikováno v:
Biology of reproduction. 63(3)
Programmed cell death (apoptosis) occurs in nearly all cell types examined, including mammalian oocytes and embryos, where it may underlie some forms of infertility in humans. Although the molecular machinery participating in apoptosis have been inte
Autor:
W A, Colburn, D L, Keefe
Publikováno v:
Journal of clinical pharmacology. 40(6)
Autor:
D L, Keefe
Publikováno v:
Seminars in oncology. 27(3)
Cardiovascular emergencies in oncology patients include all of the usual cardiac problems, as well as complications of cancer and its therapy. Pericardial effusions and tamponade, cardiac masses, and extrinsic compression of the heart and great vesse
Publikováno v:
Biology of reproduction. 63(1)
The newly developed Pol-Scope allows imaging of spindle retardance, which is an optical property of organized macromolecular structures that can be observed in living cells without fixation or staining. Experiments were undertaken to examine changes
Autor:
L, Liu, D L, Keefe
Publikováno v:
Biology of reproduction. 62(6)
Eggs must be the major locus of reproductive aging in women, because donation of eggs from younger to middle-aged women abrogates the effects of age on fertility. Oxidative stress, mitochondrial dysfunction, and apoptosis are associated with senescen
Publikováno v:
Biology of reproduction. 62(6)
The self-referencing electrode technique was employed to noninvasively measure gradients of dissolved oxygen in the medium immediately surrounding developing mouse embryos and, thereby, characterized changes in oxygen consumption and utilization duri