Zobrazeno 1 - 10 of 19 pro vyhledávání: '"D. L. Herald"'
1
Antineoplastic Agents. 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4
Autor: Jean M. Schmidt, George R. Pettit, Ernest Hamel, D. L. Herald, Monte R. Rhodes, Robin K. Pettit
Publikováno v: Journal of Medicinal Chemistry. 48:4087-4099
A series of cis- and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the 3‘-position of the aryl B-ring, were synthesized and evaluated for inhibitory activity employing six human cancer cell lines (NCI-H460 lu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308feab31a2ecaf0ccc197560b215e7d
https://doi.org/10.1021/jm0205797
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6
Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete
Autor: G R, Pettit, R, Tan, N, Melody, J M, Kielty, R K, Pettit, D L, Herald, B E, Tucker, L P, Mallavia, D L, Doubek, J M, Schmidt
Publikováno v: Bioorganicmedicinal chemistry. 7(5)
A Montana soil actinomycete, Streptomyces anulatus, produced (1 x 10(-2)% yield) a new cancer cell growth inhibitory cyclooctadepsipeptide named montanastatin (1) accompanied by the potent anticancer antibiotic valinomycin (2) in very high (5.1%) yie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b04e91914e640a64076bed625ba8146c
https://pubmed.ncbi.nlm.nih.gov/10400343
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7
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug
Autor: G R, Pettit, M R, Rhodes, D L, Herald, D J, Chaplin, M R, Stratford, E, Hamel, R K, Pettit, J C, Chapuis, D, Oliva
Publikováno v: Anti-cancer drug design. 13(8)
The (E)-stilbene isomer (2a) of the (Z)-combretastatin A-4 prodrug (1b) was efficiently prepared from (E)-combretastatin A-4 by a reaction sequence employing phosphorylation (dibenzyl chlorophosphite), cleavage (trimethyliodosilane) of the benzyl est
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fc53b56047c6cd4b4c1f35d48b38fb1
https://pubmed.ncbi.nlm.nih.gov/10335271
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8
Antineoplastic agents. 379. Synthesis of phenstatin phosphate
Autor: G R, Pettit, B, Toki, D L, Herald, P, Verdier-Pinard, M R, Boyd, E, Hamel, R K, Pettit
Publikováno v: Journal of medicinal chemistry. 41(10)
A structure-activity relationship (SAR) study of the South African willow tree (Combretum caffrum) antineoplastic constituent combretastatin A-4 (1b) directed at maintaining the (Z)-stilbene relationship of the olefin diphenyl substituents led to syn
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::92bd0f7a87a855943f91aeb64721c4af
https://pubmed.ncbi.nlm.nih.gov/9572894
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