Zobrazeno 1 - 10
of 15
pro vyhledávání: '"D. L. Hatfield"'
Publikováno v:
Molecular Microbiology. 5:1183-1186
Summary Selenocysteyl-tRNAs that decode UGA were identified previously in animal and bacterial cells and the genes for these tRNAs have been shown to be widespread in animals and eubacteria. In the present study, we identify a selenocysteyl-tRNA that
Autor:
F J, Martin-Romero, G V, Kryukov, A V, Lobanov, B A, Carlson, B J, Lee, V N, Gladyshev, D L, Hatfield
Publikováno v:
The Journal of biological chemistry. 276(32)
Selenocysteine is a rare amino acid in protein that is encoded by UGA with the requirement of a downstream mRNA stem-loop structure, the selenocysteine insertion sequence element. To detect selenoproteins in Drosophila, the entire genome was analyzed
Publikováno v:
The Journal of the Arkansas Medical Society. 97(12)
A case of primary nasal meningioma in a 69-year-old women is described. The pathologic, radiologic and clinical characteristics are described. A summary of previously published articles on the subject is given.
Publikováno v:
The Journal of biological chemistry. 276(5)
Animal thioredoxin reductases (TRs) are selenocysteine-containing flavoenzymes that utilize NADPH for reduction of thioredoxins and other protein and nonprotein substrates. Three types of mammalian TRs are known, with TR1 being a cytosolic enzyme, an
Autor:
E, Kumaraswamy, A, Malykh, K V, Korotkov, S, Kozyavkin, Y, Hu, S Y, Kwon, M E, Moustafa, B A, Carlson, M J, Berry, B J, Lee, D L, Hatfield, A M, Diamond, V N, Gladyshev
Publikováno v:
The Journal of biological chemistry. 275(45)
Selenium has been implicated in cancer prevention, but the mechanism and possible involvement of selenoproteins in this process are not understood. To elucidate whether the 15-kDa selenoprotein may play a role in cancer etiology, the complete sequenc
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 29(4)
We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutiona
Autor:
X, Zhou, S I, Park, M E, Moustafa, B A, Carlson, P F, Crain, A M, Diamond, D L, Hatfield, B J, Lee
Publikováno v:
The Journal of biological chemistry. 274(26)
The selenocysteine (Sec) tRNA population in Drosophila melanogaster is aminoacylated with serine, forms selenocysteyl-tRNA, and decodes UGA. The Km of Sec tRNA and serine tRNA for seryl-tRNA synthetase is 6.67 and 9.45 nM, respectively. Two major ban
Publikováno v:
Biomedical and environmental sciences : BES. 10(2-3)
Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we
Publikováno v:
Molecules and cells. 7(1)
In this study we show that the TATA-binding protein (TBP) interacts with the selenocysteine tRNA[Ser]Sec TATA element in a fashion analogous to the TBP-TATA interaction in RNA polymerase (Pol) II-transcribed genes even though the gene is transcribed
Publikováno v:
Biochemistry and molecular biology international. 38(2)
Selenocysteine tRNA[Ser]Sec isoacceptors contain the modified nucleotide i6A immediately 3' to the anticodon. Because synthesis of i6A is expected to be inhibited by lovastatin, the status of tRNA[Ser]Sec isoacceptors was examined in human breast car