Zobrazeno 1 - 10 of 22 pro vyhledávání: '"D. L. HERALD"'
1
Antineoplastic Agents. 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4
Autor: Jean M. Schmidt, George R. Pettit, Ernest Hamel, D. L. Herald, Monte R. Rhodes, Robin K. Pettit
Publikováno v: Journal of Medicinal Chemistry. 48:4087-4099
A series of cis- and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the 3‘-position of the aryl B-ring, were synthesized and evaluated for inhibitory activity employing six human cancer cell lines (NCI-H460 lu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::308feab31a2ecaf0ccc197560b215e7d
https://doi.org/10.1021/jm0205797
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2
Antineoplastic Agents 491.1 Synthetic Conversion of Aaptamine to Isoaaptamine, 9-Demethylaaptamine, and 4-Methylaaptamine
Autor: Larry V. Pearce, Peter M. Blumberg, George R. Pettit, Robin K. Pettit, Holger Hoffmann, John C. Knight, Kerianne C. Higgs, Alison A. Murphy, Nancy E. Lewin, D. L. Herald, James McNulty, Ernest Hamel
Publikováno v: The Journal of Organic Chemistry. 69:2251-2256
Aaptamine (1) was used as starting material for synthetic transformation to isoaaptamine (2), 9-demethylaaptamine (5), and 4-methylaaptamine (6). A general method for the selective O-demethylation of such 1H-benzo[de][1,6]-naphthyridine (1) marine sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::156dd1a84c8e362182b637561e3b6b57
https://doi.org/10.1021/jo0300486
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9
Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete
Autor: G R, Pettit, R, Tan, N, Melody, J M, Kielty, R K, Pettit, D L, Herald, B E, Tucker, L P, Mallavia, D L, Doubek, J M, Schmidt
Publikováno v: Bioorganicmedicinal chemistry. 7(5)
A Montana soil actinomycete, Streptomyces anulatus, produced (1 x 10(-2)% yield) a new cancer cell growth inhibitory cyclooctadepsipeptide named montanastatin (1) accompanied by the potent anticancer antibiotic valinomycin (2) in very high (5.1%) yie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b04e91914e640a64076bed625ba8146c
https://pubmed.ncbi.nlm.nih.gov/10400343
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10
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug
Autor: G R, Pettit, M R, Rhodes, D L, Herald, D J, Chaplin, M R, Stratford, E, Hamel, R K, Pettit, J C, Chapuis, D, Oliva
Publikováno v: Anti-cancer drug design. 13(8)
The (E)-stilbene isomer (2a) of the (Z)-combretastatin A-4 prodrug (1b) was efficiently prepared from (E)-combretastatin A-4 by a reaction sequence employing phosphorylation (dibenzyl chlorophosphite), cleavage (trimethyliodosilane) of the benzyl est
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fc53b56047c6cd4b4c1f35d48b38fb1
https://pubmed.ncbi.nlm.nih.gov/10335271
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