Zobrazeno 1 - 10
of 46
pro vyhledávání: '"D. L. DeWitt"'
Autor:
S H Ridley, S J Sarsfield, J C Lee, H F Bigg, T E Cawston, D J Taylor, D L DeWitt, J Saklatvala
Publikováno v:
The Journal of Immunology. 158:3165-3173
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 268:L294-L301
Prostaglandin synthesis represents one means by which macrophages modulate inflammation. The initial enzyme in the metabolism of arachidonic acid to prostaglandins is cyclooxygenase (COX). Both constitutive (COX-1) and inducible (COX-2) isoforms are
Publikováno v:
Journal of Biological Chemistry. 267:23451-23454
Treatment of the human lung fibroblast cell line, WI-38, with interleukin-1 alpha (IL-1 alpha) results in a large increase in the production of cytosolic phospholipase A2 (cPLA2) and prostaglandin E2 (PGE2). The IL-1-induced accumulation of cPLA2 is
Autor:
E A, Capper, A K, Roshak, B J, Bolognese, P L, Podolin, T, Smith, D L, Dewitt, K M, Anderson, L A, Marshall
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 295(3)
Tranilast (SB 252218) is a compound initially identified as an anti-atopic agent. Recently the compound has demonstrated clear beneficial effects in animal models of restenosis. Here we confirm tranilast has broad and profound effects on human monocy
Autor:
A G, Spencer, E, Thuresson, J C, Otto, I, Song, T, Smith, D L, DeWitt, R M, Garavito, W L, Smith
Publikováno v:
The Journal of biological chemistry. 274(46)
Prostaglandin endoperoxide H synthases 1 and 2 (PGHS-1 and -2) are the major targets of nonsteroidal anti-inflammatory drugs. Both isozymes are integral membrane proteins but lack transmembrane domains. X-ray crystallographic studies have led to the
Autor:
D L, DeWitt
Publikováno v:
Molecular pharmacology. 55(4)
Publikováno v:
Journal of cellular physiology. 173(3)
SPARC (secreted protein, acidic and rich in cysteine), also called osteonectin or BM-40, is a collagen-binding glycoprotein secreted by a variety of cells and is associated with functional responses involving tissue remodeling, cell movement and prol
Publikováno v:
Thrombosis and haemostasis. 78(1)
Autor:
S H, Ridley, S J, Sarsfield, J C, Lee, H F, Bigg, T E, Cawston, D J, Taylor, D L, DeWitt, J, Saklatvala
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 158(7)
The role of p38 mitogen-activated protein kinase (MAPK) in responses of human fibroblasts and vascular endothelial cells to IL-1 was investigated by use of a pyridinyl imidazole compound (SB 203580), which specifically inhibits the enzyme. SB 203580
Publikováno v:
Advances in experimental medicine and biology.