Zobrazeno 1 - 10
of 31
pro vyhledávání: '"D. L. Perkins"'
Publikováno v:
Journal of Fish Biology. 67:104-117
Analysis of genetic variation within and among samples of naturally produced Atlantic salmon (n = 372) from 7 Maine (U.S.A.) and one Canadian river were conducted based on 54 allozyme loci. Eight of the 54 loci proved polymorphic, and estimated heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6357225f3832c5f4076fa0d09c74be5f
https://doi.org/10.1111/j.0022-1112.2005.00842.x
https://doi.org/10.1111/j.0022-1112.2005.00842.x
Publikováno v:
The Journal of Immunology. 158:4074-4081
T cell activation requires at least two signals transduced by the Ag-specific TCR plus a costimulatory receptor. The CD28 costimulatory molecule has been shown to promote T cell proliferation and cytokine production. CTLA-4, a cell surface molecule h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbbd51c09baa001a0a399c3999f462b2
https://doi.org/10.4049/jimmunol.158.9.4074
https://doi.org/10.4049/jimmunol.158.9.4074
Publikováno v:
The Journal of Immunology. 156:4961-4968
The lpr mutation, a disruption of the fas gene, induces spontaneous autoimmunity characterized by high titers of autoantibodies, lymphadenopathy, autoreactive T cells, and early mortality. The mechanism of autoimmunity, however, remains unknown. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf6525863b3c83ec87f7eedc9868990
https://doi.org/10.4049/jimmunol.156.12.4961
https://doi.org/10.4049/jimmunol.156.12.4961
Publikováno v:
The Journal of Immunology. 150:4284-4291
TCR (beta-chain) transgenic mice were tolerized with the superantigen staphylococcal enterotoxin B (SEB). Three to 28 days after tolerization with SEB, flow cytometry of peripheral T cells showed the persistence of SEB-unresponsive T cells that did n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b85e8393067f17e25ca7a10a5f02102
https://doi.org/10.4049/jimmunol.150.10.4284
https://doi.org/10.4049/jimmunol.150.10.4284
Publikováno v:
The Journal of Immunology. 148:3034-3041
The T cell response to complex protein Ag typically focuses on a few, and frequently a single, immunodominant epitope. Several groups have proposed that the mechanism of immunodominance is determined by the steps of Ag processing and presentation inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84cf5a1aa993480371fd23b5cc882e34
https://doi.org/10.4049/jimmunol.148.10.3034
https://doi.org/10.4049/jimmunol.148.10.3034
Publikováno v:
The Journal of Immunology. 147:3296-3302
In a murine model of T cell-mediated autoimmune disease, experimental autoimmune encephalitis (EAE), 80% of all encephalitogenic T cell clones in H-2u mice use the V beta 8.2 TCR element. To induce EAE in susceptible strains of mice either heat-kille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecd2ae49dfe297797b395af8d3df6331
https://doi.org/10.4049/jimmunol.147.10.3296
https://doi.org/10.4049/jimmunol.147.10.3296
Autor:
Y S Wang, D L Perkins
Publikováno v:
The Journal of Immunology. 147:804-809
The degree to which processed self-peptides contribute to the stimulation of autoreactive T cells has not been determined. In this study we have analyzed a panel of autoreactive T cell hybridomas from normal C57BL/26 mice produced by fusing periphera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ebeccc0a222d5083911bfc93e234029
https://doi.org/10.4049/jimmunol.147.3.804
https://doi.org/10.4049/jimmunol.147.3.804
Publikováno v:
The Journal of Immunology. 146:2960-2964
Despite the tremendous plasticity of the TCR repertoire, T cells recognize a limited number of antigenic sites (frequently a single site, or immunodominant epitope) on a complex protein Ag. Current models suggest that the immunodominant epitope of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0057f455c2f71eaa8d9193caf4280e8
https://doi.org/10.4049/jimmunol.146.9.2960
https://doi.org/10.4049/jimmunol.146.9.2960
Publikováno v:
The Journal of Immunology. 146:2137-2144
We have used an approach of linking previously characterized T cell epitopes into immunologically complex synthetic peptides in order to investigate the mechanism of immunodominance. Our results show that first, cI12-26 is highly dominant following i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58dc427a71544c96c96b2ee1569981e1
https://doi.org/10.4049/jimmunol.146.7.2137
https://doi.org/10.4049/jimmunol.146.7.2137
Publikováno v:
The Journal of Immunology. 145:549-555
Stem cells from a lpr/lpr mouse do not cause the lpr syndrome characteristic of unmanipulated MRL/lpr mice when injected into nonautoimmune neonatal mice. Instead, these neonatal chimeras gradually become markedly lymphopenic. As adults, only limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b5efa293e75b59a5f2d63d2b38d068
https://doi.org/10.4049/jimmunol.145.2.549
https://doi.org/10.4049/jimmunol.145.2.549