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Akademický článek

Game changer in the diagnosis of bipolar disorder using RNA editing-based blood biomarkers

Autor: J.-D. Abraham, N. Salvetat, F. Checa-Robles, V. Patel, C. Cayzac, B. Dubuc, D. Vetter, J.-P. Lang, P. Courtet, D. Kupfer, D. Weissmann

Publikováno v: European Psychiatry, Vol 64, Pp S77-S78 (2021)

Introduction In clinical practice, differentiating Bipolar Disorder (BD) from unipolar depression is challenging due to the depressive symptoms, which are the core presentations of both disorders. Patients with BD are often misdiagnosed during depres

Externí odkaz: https://doaj.org/article/a11bf59ccc4846dca2d57c38599f1bd9

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CYP2C subfamily, primarily CYP2C9, catalyses the enantioselective demethylation of the endocrine disruptor pesticide methoxychlor in human liver microsomes: use of inhibitory monoclonal antibodies in P450 identification

Autor: D. Kupfer, Y. Hu, Harry V. Gelboin, Kristopher W. Krausz

Publikováno v: Xenobiotica. 34:117-132

1. The endocrine disruptor pesticide methoxychlor undergoes O-demethylation by mammalian liver microsomes forming chiral mono-phenolic (1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane, i.e. mono-OH-M) and achiral bis-phenolic oestrogeni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d7beab83deb8b9f7f9b25a90d15775
https://doi.org/10.1080/00498250310001644535

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CYP2D6-mediated catalysis of tamoxifen aromatic hydroxylation with an NIH shift: similar hydroxylation mechanism in chicken, rat and human liver microsomes

Autor: S S Dehal, G Hynd, D. Kupfer, Y. Hu, G B Jones

Publikováno v: Xenobiotica. 33:141-151

1. 4-Tritiated-tamoxifen (4-[(3)H]-tamoxifen) and 4-deuterated-tamoxifen (4-[(2)H]-tamoxifen) were synthesized to examine tamoxifen metabolism by human P450 (CYP) forms and also for the possibility of determining tamoxifen-4-hydroxylation in humans i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36276e1cdeef12c2da35bdd511da1513
https://doi.org/10.1080/0049825021000042733

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Juvenile Breast Hypertrophy: Report of a Familial Pattern and Review of the Literature

Autor: D, Kupfer, D, Dingman, R, Broadbent

Publikováno v: Plastic and Reconstructive Surgery. 90:303-309

Juvenile hypertrophy of the breast is a relatively rare condition rapidly leading to gigantomastia in peripubertal females. The pathology is limited to the breast, with otherwise normal growth and development. We have reported the first familial patt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1251152657cde3b61a1a07b55c602a
https://doi.org/10.1097/00006534-199290020-00023

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Duration of treatment with antidepressants in depressive disorder

Autor: S Carney, JR Geddes, T Furukawa, G Goodwin, D Kupfer, C Davies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ce14dc669c05767c804fc0466e965f
https://doi.org/10.1002/14651858.cd003386.pub2

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P.2.c.018 Morningness and eveningness changes after agomelatine treatment in major depression

Autor: F. Corruble, P.-M. Llorca, Ellen Frank, P. Gorwood, F. Bayle, D. Kupfer, Guillaume Vaiva, Florence Gressier, P. Courtet

Publikováno v: European Neuropsychopharmacology. 22:S260-S261

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bb5a9d390a2be3c6ab90e55cac3bcfd
https://doi.org/10.1016/s0924-977x(12)70391-7

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Concurrent flavin-containing monooxygenase down regulation and cytochrome P450 induction by dietary indoles in the rat: implication for drug-drug interactions

Autor: D E, Williams, S, Katchamar, S A, Larsen-Su, D M, Stresser, S S, Dehal, D, Kupfer

Publikováno v: Advances in experimental medicine and biology. 500

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d01499f2c65c82ed218ec1503236b1c4
https://pubmed.ncbi.nlm.nih.gov/11765009

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Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system

Autor: D, Blizard, T, Sueyoshi, M, Negishi, S S, Dehal, D, Kupfer

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 29(6)

Methoxychlor, a structural analog of the DDT pesticide, was previously shown to induce rat hepatic CYP2B and -3A mRNAs and the corresponding proteins [J Biochem Mol Toxicol 1998;12:315-323], Additionally, methoxychlor was found to activate the consti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dae09d7d2f23fc5c4b477256a015e882
https://pubmed.ncbi.nlm.nih.gov/11353743

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Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies

Autor: K W, Gaido, S C, Maness, D P, McDonnell, S S, Dehal, D, Kupfer, S, Safe

Publikováno v: Molecular pharmacology. 58(4)

We previously demonstrated differential interactions of the methoxychlor metabolite 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE) with estrogen receptor alpha (ERalpha), ERbeta, and the androgen receptor (AR). In this study, we characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6aaf187a25dedfcec3dc38ea3e36c75d
https://pubmed.ncbi.nlm.nih.gov/10999957

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Concurrent flavin-containing monooxygenase down-regulation and cytochrome P-450 induction by dietary indoles in rat: implications for drug-drug interaction

Autor: S, Katchamart, D M, Stresser, S S, Dehal, D, Kupfer, D E, Williams

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 28(8)

Our laboratory has previously shown that dietary administration of indole-3-carbinol (I3C) to male Fischer 344 rats has the very unusual property of inducing hepatic levels of a number of cytochrome P450s (CYPs), especially CYP1A1, while markedly inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f6f5b05baba344c1dba342ebbe0a4d32
https://pubmed.ncbi.nlm.nih.gov/10901703

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