Zobrazeno 1 - 10
of 612
pro vyhledávání: '"D. Kostic"'
Autor:
D. Kostic, M. Nowakowska, J. Freundt Revilla, F. Attig, K. Rohn, F. Gualtieri, W. Baumgärtner, H. Potschka, A. Tipold
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Canine drug-resistant epilepsy is a prevailing issue in veterinary neurology. Alternative or additional treatment with cannabinoids is showing promising results in seizure management. A crucial component of the endocannabinoid system, cannab
Externí odkaz:
https://doaj.org/article/a06aaa9778ee4d98817ddbbf4ed94afa
Autor:
Alexandra Proctor, Shadi Parvinroo, Tanner Richie, Xinglin Jia, Sonny T. M. Lee, Peter D. Karp, Suzanne Paley, Aleksandar D. Kostic, Joseph F. Pierre, Michael J. Wannemuehler, Gregory J. Phillips
Publikováno v:
mSystems, Vol 7, Iss 5 (2022)
ABSTRACT Animals colonized with a defined microbiota represent useful experimental systems to investigate microbiome function. The altered Schaedler flora (ASF) represents a consortium of eight murine bacterial species that have been used for more th
Externí odkaz:
https://doaj.org/article/f2ac8f4ddec5422cb279d74b55f0ef68
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, combing the massive gene-universe of the gut microbiome to identify strain-specific, cross-disease, associations across seven human diseases, the authors introduce the concept of microbiome architecture, defined as the complete set of positive
Externí odkaz:
https://doaj.org/article/aa92ba967fec46d998689080a37ed860
Autor:
Salina Moon, John J. Tsay, Heather Lampert, Zaipul I. Md Dom, Aleksandar D. Kostic, Adam Smiles, Monika A. Niewczas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract A substantial number of subjects with Type 1 Diabetes (T1D) of long duration never develop albuminuria or renal function impairment, yet the underlying protective mechanisms remain unknown. Therefore, our study included 308 Joslin Kidney Stu
Externí odkaz:
https://doaj.org/article/7623be6c5615427c8d8ec936964eba27
Autor:
Braden T Tierney, Yingxuan Tan, Zhen Yang, Bing Shui, Michaela J Walker, Benjamin M Kent, Aleksandar D Kostic, Chirag J Patel
Publikováno v:
PLoS Biology, Vol 20, Iss 3, p e3001556 (2022)
Evaluating the relationship between the human gut microbiome and disease requires computing reliable statistical associations. Here, using millions of different association modeling strategies, we evaluated the consistency-or robustness-of microbiome
Externí odkaz:
https://doaj.org/article/4223f8b944c749438638928e87319b45
Autor:
Braden T. Tierney, Erika Szymanski, James R. Henriksen, Aleksandar D. Kostic, Chirag J. Patel
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
The technological leap of DNA sequencing generated a tension between modern metagenomics and historical microbiology. We are forcibly harmonizing the output of a modern tool with centuries of experimental knowledge derived from culture-based microbio
Externí odkaz:
https://doaj.org/article/55d0011dc7914d8f85fdc1d03cff74fa
Autor:
Braden T Tierney, Elizabeth Anderson, Yingxuan Tan, Kajal Claypool, Sivateja Tangirala, Aleksandar D Kostic, Arjun K Manrai, Chirag J Patel
Publikováno v:
PLoS Biology, Vol 19, Iss 9, p e3001398 (2021)
Hypothesis generation in observational, biomedical data science often starts with computing an association or identifying the statistical relationship between a dependent and an independent variable. However, the outcome of this process depends funda
Externí odkaz:
https://doaj.org/article/7a473add305f4aa796f527371dfa9008
Autor:
Himel Mallick, Eric A. Franzosa, Lauren J. Mclver, Soumya Banerjee, Alexandra Sirota-Madi, Aleksandar D. Kostic, Clary B. Clish, Hera Vlamakis, Ramnik J. Xavier, Curtis Huttenhower
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Obtaining metabolomic data from microbial communities can be costly and difficult, whereas many microbial community sequence datasets are already available. Here Mallick et al. describe a computational approach to predict metabolic features from micr
Externí odkaz:
https://doaj.org/article/953511452d6847d9a93027a58764b2b1
Publikováno v:
Neurobiology of Pain, Vol 9, Iss , Pp 100056- (2021)
Nociceptor sensory neurons innervate barrier tissues that are constantly exposed to microbial stimuli. During infection, pathogenic microorganisms can breach barrier surfaces and produce pain by directly activating nociceptors. Microorganisms that li
Externí odkaz:
https://doaj.org/article/fad361649c394c69931f4074350dda16
Autor:
Alan Le Goallec, Braden T Tierney, Jacob M Luber, Evan M Cofer, Aleksandar D Kostic, Chirag J Patel
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 5, p e1007895 (2020)
The microbiome is a new frontier for building predictors of human phenotypes. However, machine learning in the microbiome is fraught with issues of reproducibility, driven in large part by the wide range of analytic models and metagenomic data types
Externí odkaz:
https://doaj.org/article/0689f07677a344cba448cfd9543fa630