Implementation of automated behavior metrics to evaluate voluntary wheel running effects on inflammatory-erosive arthritis and interstitial lung disease in TNF-Tg mice

Autor: H. Mark Kenney, Ronald W. Wood, Gabriel Ramirez, Richard D. Bell, Kiana L. Chen, Lindsay Schnur, Homaira Rahimi, Benjamin D. Korman, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Calvin L. Cole

Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)

Abstract Background Although treatment options and algorithms for rheumatoid arthritis (RA) have improved remarkably in recent decades, there continues to be no definitive cure or pharmacologic intervention with reliable long-term efficacy. For this

Externí odkaz: https://doaj.org/article/19b87fe1e574417196fd3fe8ae9f637d

Thy-1 plays a pathogenic role and is a potential biomarker for skin fibrosis in scleroderma

Autor: Roberta G. Marangoni, Poulami Datta, Ananta Paine, Stacey Duemmel, Marc Nuzzo, Laura Sherwood, John Varga, Christopher Ritchlin, Benjamin D. Korman

Publikováno v: JCI Insight, Vol 7, Iss 19 (2022)

Thy-1 (CD90) is a well-known marker of fibroblasts implicated in organ fibrosis, but its contribution to skin fibrosis remains unknown. We examined Thy-1 expression in scleroderma skin and its potential role as a biomarker and pathogenic factor in an

Externí odkaz: https://doaj.org/article/8977fc025ae446a38d0fce3046645be0

Multi-omics Analysis Identifies IgG2b Class-Switching with ALCAM-CD6 Co-Stimulation in Lymph Nodes During Advanced Inflammatory-Erosive Arthritis

Autor: H. Mark Kenney, Javier Rangel-Moreno, Yue Peng, Kiana L. Chen, Jennifer Bruno, Abdul Embong, Elizabeth Pritchett, Jeffrey I. Fox, Sally Quataert, Gowrishankar Muthukrishnan, Ronald W. Wood, Benjamin D. Korman, Jennifer H. Anolik, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz, Chia-Lung Wu

Defective lymphatic drainage and B-cell translocation into joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying this lymphatic dysfunction remain po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40f96a0822d1d9f434482e5e4b55207
https://doi.org/10.1101/2022.10.27.514103

Alterations of the Primary Cilia Gene SPAG17 and SOX9 Locus Noncoding RNAs Identified by RNA-Sequencing Analysis in Patients With Systemic Sclerosis

Autor: Elisha D. O. Roberson, Mary Carns, Li Cao, Kathleen Aren, Isaac A. Goldberg, David J. Morales‐Heil, Benjamin D. Korman, John P. Atkinson, John Varga

Publikováno v: Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 75(1)

Systemic sclerosis (SSc) is characterized by immune activation, vasculopathy, and unresolving fibrosis in the skin, lungs, and other organs. We performed RNA-sequencing analysis on skin biopsy samples and peripheral blood mononuclear cells (PBMCs) fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d89fc834089b60c65da31a45d9df24a
https://pubmed.ncbi.nlm.nih.gov/35762854

HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

Autor: Reem Kais Jan, Daniel L. Kastner, Francesco Boin, Chris T. Derk, Kathleen D. Kolstad, Vivien Hsu, Heather Gladue, Virginia D. Steen, Avram Goldberg, Paula S. Ramos, Victoria K. Shanmugam, Dinesh Khanna, Lorinda Chung, Ayo P. Doumatey, Richard M. Silver, Elana J. Bernstein, Amy R. Bentley, Pravitt Gourh, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Lesley Ann Saketkoo, Fredrick M. Wigley, Steven E. Boyden, Brynn Kron, Elena Schiopu, Benjamin D. Korman, Lindsey A. Criswell, Peter J. Steinbach, S. Louis Bridges, Suzanne Kafaja, Thomas A. Medsger, Daniel Shriner, James C. Mullikin, Settara C. Chandrasekharappa, Jessica K. Gordon, Robyn T. Domsic, Elaine F. Remmers, John Varga, Adebowale Adeyemo, Sarah A. Safran, Theresa Alexander, Marcin Trojanowski, Charles N. Rotimi

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1

Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a93c337973c75c6b198b9d9bb23399b
https://doi.org/10.1073/pnas.1906593116