Zobrazeno 1 - 10
of 259
pro vyhledávání: '"D. Klika"'
Autor:
Glory P. Adebayo, Gbolahan O. Oduselu, Damilola V. Aderohunmu, Karel D. Klika, Grace I. Olasehinde, Olayinka O. Ajani, Ezekiel Adebiyi
Publikováno v:
Arabian Journal of Chemistry, Vol 17, Iss 2, Pp 105573- (2024)
Malaria remains a significant global health concern causing numerous fatalities and the emergence of antimalarial drug resistance highlights the urgent need for novel therapeutic options with innovative mechanisms of action and targets. This study ai
Externí odkaz:
https://doaj.org/article/2d07865dbaa349c183cc53f755c129f6
Autor:
Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. König, Georg Royl, Markus Schwaninger
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did not improve stroke ou
Externí odkaz:
https://doaj.org/article/059cd2a8279e4ad29ee5c62318e45b7c
Publikováno v:
Separations, Vol 10, Iss 7, p 382 (2023)
α-Pinene is an intriguing monoterpene as it has been reported to undergo the self-disproportionation of enantiomers (SDE) phenomenon via gas chromatography (GC), the only compound to decisively demonstrate this. Examples of the SDE involving the gas
Externí odkaz:
https://doaj.org/article/e514d56f28ba421db87f62eadfa7fb53
Autor:
Peter Kvacskay, Nina Yao, Jürgen-Heinz Schnotz, Roberta Scarpone, Rui de Albuquerque Carvalho, Karel D. Klika, Wolfgang Merkt, Theresa Tretter, Hanns-Martin Lorenz, Lars-Oliver Tykocinski
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Background A dysregulated glucose metabolism in synovial fibroblasts (SF) has been associated with their aggressive phenotype in rheumatoid arthritis (RA). Even though T helper (Th) cells are key effector cells in the propagation and exacerb
Externí odkaz:
https://doaj.org/article/1a335b7d74db4ce9bd0f8b950241b6de
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Zingiberaceae plants are well known for their use in ethnomedicine. Curcuma mutabilis Škorničk., M. Sabu & Prasanthk., is an endemic Zingiberaceae species from Western Ghats of Kerala, India. Here, we report for the first time, the antican
Externí odkaz:
https://doaj.org/article/7d1465b311ea491a9401a377e66482d4
Autor:
Patrycja Rogala, Agnieszka Jabłońska-Wawrzycka, Grzegorz Czerwonka, Katarzyna Kazimierczuk, Katarzyna Gałczyńska, Sławomir Michałkiewicz, Justyna Kalinowska-Tłuścik, Marta Karpiel, Karel D. Klika
Publikováno v:
Molecules, Vol 28, Iss 1, p 40 (2022)
Half-sandwich Ru(II) complexes belong to group of biologically active metallo-compounds with promising antimicrobial and anticancer activity. Herein, we report the synthesis and characterization of arene ruthenium complexes containing benzimidazole m
Externí odkaz:
https://doaj.org/article/5ee44986b37b4bad804b2e3c07429aeb
Publikováno v:
ACS Pharmacology & Translational Science. 6:727-737
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Riproximin (Rpx) is a type II ribosome-inactivating protein with specific anti-proliferative activity. It was purified from Ximenia americana by affinity chromatography using a resin coupled with lactosyl residues. The same technique facilitated isol
Externí odkaz:
https://doaj.org/article/99ffcdd391ed400fa8d023eaf98a12d9
Autor:
Florian Umstätter, Julia Werner, Leah Zerlin, Eric Mühlberg, Christian Kleist, Karel D. Klika, Tobias Hertlein, Barbro Beijer, Cornelius Domhan, Stefan Zimmermann, Knut Ohlsen, Uwe Haberkorn, Walter Mier, Philipp Uhl
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 159 (2022)
As multidrug-resistant bacteria represent a concerning burden, experts insist on the need for a dramatic rethinking on antibiotic use and development in order to avoid a post-antibiotic era. New and rapidly developable strategies for antimicrobial su
Externí odkaz:
https://doaj.org/article/88e45bb8f9a14a738a7f13499614142e
Autor:
Tim Weigand, Benjamin Singler, Thomas Fleming, Peter Nawroth, Karel D. Klika, Christian Thiel, Hans Baelde, Sven F. Garbade, Andreas H. Wagner, Markus Hecker, Benito A. Yard, Albert Amberger, Johannes Zschocke, Claus P. Schmitt, Verena Peters
Publikováno v:
Cellular Physiology and Biochemistry, Vol 46, Iss 2, Pp 713-726 (2018)
Background/Aims: Reactive dicarbonyl compounds, such as methylglyoxal (MG), contribute to diabetic complications. MG-scavenging capacities of carnosine and anserine, which have been shown to mitigate diabetic nephropathy, were evaluated in vitro and
Externí odkaz:
https://doaj.org/article/9758b7d51f2b44179855a109b72ae677