Výsledky vyhledávání

A study of liquid metal alloy ion sources for the production of ions of interest in the microelectronics industry

Autor: J. Teichert, D. Kioussis, Th. Ganetsos, G.L.R. Mair, Lothar Bischoff

Publikováno v: Solid State Electronics 45 (2001) 1049-1054

This is a comprehensive study of the characteristics of an AuGeSi and CoNd liquid metal alloy ion sources [Focused ion beams from liquid metal ion sources, 1991]. Such characteristics include current–voltage curves and ion beam mass-spectra. A care

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dae06476e36ecb99d732938d7aac52c
https://doi.org/10.1016/s0038-1101(01)00164-2

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Aspartate at position 57 of nonobese diabetic I-Ag7 beta-chain diminishes the spontaneous incidence of insulin-dependent diabetes mellitus

Autor: R Quartey-Papafio, T Lund, P Chandler, J Picard, P Ozegbe, S Day, P R Hutchings, L O'Reilly, D Kioussis, E Simpson

Publikováno v: The Journal of Immunology. 154:5567-5575

MHC class II genes have been shown to influence the development of the autoimmune disease insulin-dependent diabetes mellitus (IDDM) in the nonobese diabetic (NOD) mouse. In human IDDM it has been suggested that the presence of an aspartate at positi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e3d47c65d5e755b805b16c5f41c7a2f
https://doi.org/10.4049/jimmunol.154.10.5567

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Mechanism of lymphocyte function-associated molecule 3-Ig fusion proteins inhibition of T cell responses. Structure/function analysis in vitro and in human CD2 transgenic mice

Autor: G R Majeau, W Meier, B Jimmo, D Kioussis, P S Hochman

Publikováno v: The Journal of Immunology. 152:2753-2767

Soluble ligands specific for cell surface molecules involved in APC-T cell interactions can signal cells and modulate immune responses. Recently, we reported that LFA3TIP, a fusion protein comprised of the first LFA-3 extracellular domain fused to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76f8ef4b6c1c410f458a183f81986098
https://doi.org/10.4049/jimmunol.152.6.2753

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Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes

Autor: L Probert, J Keffer, P Corbella, H Cazlaris, E Patsavoudi, S Stephens, E Kaslaris, D Kioussis, G Kollias

Publikováno v: The Journal of Immunology. 151:1894-1906

To evaluate the biologic potential of T cell-specific TNF production in vivo, we have generated transgenic mice constitutively expressing TNF in their T cell compartment. This was achieved by placing a wild-type or a 3'-UTR modified fragment of the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9cc242c5f0bc53aed126d29f21e41de
https://doi.org/10.4049/jimmunol.151.4.1894

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Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha

Autor: D Kioussis, Izumi Nakashima, Hiroyoshi Hidaka, T Isomura, Takashi Iwamoto, Masatoshi Hagiwara

Publikováno v: Journal of Biological Chemistry. 267:18644-18648

Protein kinase C (PKC) has been believed to play an important role in the differentiation/proliferation of various kinds of mammalian cells. To analyze its function in living animals, we have established a transgenic mouse line carrying rabbit protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0aefdc4c11b4a487184931f5a026ef
https://doi.org/10.1016/s0021-9258(19)37009-7

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Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

Autor: Lesley Probert, J. Keffer, E. Kaslaris, Spiros Georgopoulos, D. Kioussis, H. Cazlaris, George Kollias

Publikováno v: The EMBO Journal. 10:4025-4031

We have generated transgenic mouse lines carrying and expressing wild-type and 3'-modified human tumour necrosis factor (hTNF-alpha, cachectin) transgenes. We show that correct, endotoxin-responsive and macrophage-specific hTNF gene expression can be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1524475078c7f8d93a84bacc6c2a2590
https://doi.org/10.1002/j.1460-2075.1991.tb04978.x

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Reconstitution of an active surface CD2 by DNA transfer in CD2-CD3+ Jurkat cells facilitates CD3-T cell receptor-mediated IL-2 production

Autor: H Makni, J S Malter, J C Reed, S Nobuhiko, G Lang, D Kioussis, G Trinchieri, M Kamoun

Publikováno v: The Journal of Immunology. 146:2522-2529

To investigate the requirements for CD2 expression in the activation of T lymphocytes via the CD3-TCR complex, we produced and characterized a series of CD2-variants of the IL-2 producing Jurkat leukemia cell line, J32 (surface phenotype, CD2+, CD3+,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2adf70bd65a3358a480ddd7520045d8e
https://doi.org/10.4049/jimmunol.146.8.2522

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Tracing and characterization of the low-avidity self-specific T cell repertoire

Autor: K E, de Visser, T A, Cordaro, D, Kioussis, J B, Haanen, T N, Schumacher, A M, Kruisbeek

Publikováno v: European journal of immunology. 30(5)

It is well established that expression of self antigens results in the deletion of the functional high-avidity self-specific T cell repertoire. Due to the low frequency of naturally occurring low-avidity self-specific T cells, a detailed evaluation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2f67888b4bf2e0c43858d3ac169ab97
https://pubmed.ncbi.nlm.nih.gov/10820394

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