Tofacitinib Safety and Effectiveness in Canadian Patients with Rheumatoid Arthritis by Cardiovascular Risk Enrichment: Subanalysis of the CANTORAL Study

Autor: Boulos Haraoui, Majed Khraishi, Denis Choquette, Isabelle Fortin, Cassandra D. Kinch, Corina Galos, Patrice Roy, David Gruben, Julie Vaillancourt, John S. Sampalis, Edward C. Keystone

Publikováno v: Rheumatology and Therapy, Vol 11, Iss 6, Pp 1629-1648 (2024)

Abstract Introduction ORAL Surveillance, a post-authorisation safety study of patients with rheumatoid arthritis (RA) enriched for cardiovascular (CV) risk, demonstrated increased risk of major adverse CV events (MACE) and malignancies (excluding non

Externí odkaz: https://doaj.org/article/214537ed140d4f4797dda101eed1469c

Impact of Race on the Efficacy and Safety of Tofacitinib in Rheumatoid Arthritis: Post Hoc Analysis of Pooled Clinical Trials

Autor: Grace C. Wright, Eduardo Mysler, Kenneth Kwok, Mary Jane Cadatal, Rebecca Germino, Arne Yndestad, Cassandra D. Kinch, Alexis Ogdie

Publikováno v: Rheumatology and Therapy, Vol 11, Iss 5, Pp 1135-1164 (2024)

Abstract Introduction Racial disparities in disease activity, clinical outcomes, and treatment survival persist despite advancements in rheumatoid arthritis (RA) therapies and clinical management. In this post hoc analysis of pooled data from the tof

Externí odkaz: https://doaj.org/article/7fc4cc04798247339219428e07071d32

Impact of Tofacitinib on Components of the ACR Response Criteria

Autor: Louis Bessette, Eduardo Mysler, Cassandra D. Kinch, Kenneth Kwok, Tatjana Lukic, Phu Vinh On, Ronald F. van Vollenhoven

Publikováno v: Journal of Rheumatology, 49(6), 566-576. Journal of Rheumatology
Journal of rheumatology, 49(6), 566-576. Journal of Rheumatology
Bessette, L, Mysler, E, Kinch, C D, Kwok, K, Lukic, T, On, P V & van Vollenhoven, R F 2022, ' Impact of Tofacitinib on Components of the ACR Response Criteria : Post Hoc Analysis of Phase III and Phase IIIb/IV Trials ', Journal of Rheumatology, vol. 49, no. 6, pp. 566-576 . https://doi.org/10.3899/jrheum.210707

Objective.To evaluate the effect of tofacitinib (TOF) on American College of Rheumatology (ACR) response criteria components in patients with rheumatoid arthritis (RA).Methods.This post hoc analysis pooled data from RA phase III randomized controlled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861d1d62fad79f40b45cdee20fbef7e4
https://doi.org/10.3899/jrheum.210707

Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture

Autor: Deborah M. Kurrasch, Hamid R. Habibi, Cassandra D. Kinch

Publikováno v: Aquatic toxicology (Amsterdam, Netherlands). 175

Exposure to environmental contaminants has been linked to developmental and reproductive abnormalities leading to infertility, spontaneous abortion, reduced number of offspring, and metabolic disorders. In addition, there is evidence linking environm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85f83eb9d972f133c8fd6d41e3b0b9d
https://pubmed.ncbi.nlm.nih.gov/27107150

RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis

Autor: Deborah M. Kurrasch, Carol Schuurmans, Jennifer A. Chan, Saiqun Li, Samuel Lawn, David D. Eisenstat, Rajiv Dixit, Pierre Mattar, Grey Wilkinson, Cassandra D. Kinch

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(6)

Neural cell fate specification is well understood in the embryonic cerebral cortex, where the proneural genesNeurog2andAscl1are key cell fate determinants. What is less well understood is how cellular diversity is generated in brain tumors. Gliomas a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874d4493cf15884f38054849c4b0b66a
https://pubmed.ncbi.nlm.nih.gov/24501358