Zobrazeno 1 - 10 of 29 pro vyhledávání: '"D. Kierstead"'
1
Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations
Autor: Mary J. Tevethia, Holly A. Lacko, D L Thompson, T D Kierstead
Publikováno v: Journal of Virology. 71:1888-1896
The simian virus 40 large T antigen is sufficient to confer on cells multiple transformed cell growth characteristics, including growth to a high cell density, rapid growth in medium containing low serum concentrations, and anchorage-independent grow
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a3e1774cb2727b71b235aa643871b9
https://doi.org/10.1128/jvi.71.3.1888-1896.1997
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2
Structural stability of adenovirus type 5
Autor: Miller O. Scott, Christopher M. Wiethoff, Anthony P. Green, C. Russell Middaugh, Jason Rexroad, Timothy D. Kierstead
Publikováno v: Journal of pharmaceutical sciences. 92(3)
Thermally induced structural changes in adenovirus type 5 (Ad) in the presence of either 2 or 10% sucrose were investigated using a variety of biophysical techniques. In solutions containing 2% sucrose, a highly cooperative transition in the structur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35f54f2f44dff85a0a9de71d3b0cc9b6
https://pubmed.ncbi.nlm.nih.gov/12587128
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3
A new scalable method for the purification of recombinant adenovirus vectors
Autor: Timothy D. Kierstead, Irene Beaupré, Miller O. Scott, James Huang, Anthony P. Green, James M. Wilson, Guangping Gao
Publikováno v: Human gene therapy. 13(16)
Recombinant adenovirus vectors continue to be the preferred vectors for many types of gene therapy. However, issues regarding production and safety as well as the development of a scalable process for these vectors remain a challenge. Additionally, a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaad52b8032112c7ea1e3e29e00f5452
https://pubmed.ncbi.nlm.nih.gov/12427304
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5
Measurement of cerebral blood volume with subtraction three-dimensional functional CT
Autor: L M, Hamberg, G J, Hunter, D, Kierstead, E H, Lo, R, Gilberto González, G L, Wolf
Publikováno v: AJNR Am J Neuroradiol
PURPOSE: To implement a three-dimensional subtraction functional CT technique to permit rapid quantitative mapping of regional cerebral blood volume (CBV). METHODS: The 3-D functional CT technique was implemented in a rabbit model using normal and is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::975e3ace0305d73a0e5b81af549f1c2b
https://pubmed.ncbi.nlm.nih.gov/8933870
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6
Database of mutations that alter the large tumor antigen in simian virus 40
Autor: Timothy D. Kierstead, James M. Pipas
Publikováno v: Nucleic acids research. 24(1)
The SV40 T antigen database is a listing of plasmids and/or viruses that express mutant forms of the virus-encoded large T antigen protein. The parental virus strain, nucleic acid sequence of the mutations, the effect of the mutation on the T antigen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081e5161b60b777584f3193df778bdef
https://pubmed.ncbi.nlm.nih.gov/8594559
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7
793. Adenopure LS™ Large Scale Kit for Purification of Recombinant Adenovirus
Autor: Tawfiq Hazboun, Timothy D. Kierstead, Anthony P. Green
Publikováno v: Molecular Therapy. 9:S300-S301
Recombinant adenovirus vectors are still the preferred choice for many types of gene therapy. However, the availability of a process to purify larger quantities of these vectors at high purity and on a consistent basis for screening and small animal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33eee337caffcfe39f4c383d50be7a42
https://doi.org/10.1016/j.ymthe.2004.06.883
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8
Association of p53 binding and immortalization of primary C57BL/6 mouse embryo fibroblasts by using simian virus 40 T-antigen mutants bearing internal overlapping deletion mutations
Autor: Mary J. Tevethia, T D Kierstead
To more precisely map the immortalization and p53 binding domains of T antigen, a large series of overlapping deletion mutations were created between codons 251 to 651 by utilizing a combination of Bal 31 deletion and oligonucleotide-directed mutagen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a5f3f87f87cc237815485f473cf7143
https://europepmc.org/articles/PMC240236/
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9
427. Adipose Tissue as a Novel Target for In Vivo Gene Transfer Using Adeno-Associate Virus (AAV) Vectors
Autor: Donald Fisher, Michael Moxley, Timothy D. Kierstead, Anthony P. Green
Publikováno v: Molecular Therapy. 9:S163
Recombinant Adeno-Associated Virus (AAV) is an important vector for efficient gene transfer. AAV generates minimal immune responses and recombination of surface capsid proteins to generate pseudotypes has allowed for the development of more efficient
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1c620ee1ded0507dbadbae4802d87c1
https://doi.org/10.1016/j.ymthe.2004.06.359
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