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Akademický článek

Genetic analysis of foliar disease resistance, yield and nutritional quality traits in groundnut

Autor: Sunil Chaudhari, D. Khare, S. Sundravadana, Murali T. Variath, Surendra S. Manohar and, P. Janila

Publikováno v: Electronic Journal of Plant Breeding, Vol 8, Iss 2, Pp 485-493 (2017)

A set of 340 diverse groundnut genotypes included in Genomic Selection Panel (GSP) was used to evaluate genetic parameters and trait associations for resistance to rust and late leaf spot (LLS) along with yield and nutritional quality traits. The fin

Externí odkaz: https://doaj.org/article/0b738e0be74c48f9b2bb5ac8bdc7350c

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Akademický článek

The chemoenzymatic synthesis of glycan-terminated oligo(Leu)x

Autor: Sarah P. Black, Melinda Liu, Cesar Castillo, Wynne Coradeli, Filbert Totsingan, Cody B. Edson, Sagar D. Khare, Richard A. Gross

Publikováno v: Frontiers in Catalysis, Vol 3 (2024)

Introduction: Glycopeptides contain carbohydrate moieties (glycans) covalently attached to the side chain and/or terminal peptide units. Since glycans are present on cell surfaces, these constructs can potentially address a wide array of therapeutic

Externí odkaz: https://doaj.org/article/87a65eee7c094f5bb2a0a7527e7a89d2

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Akademický článek

468 Characteristics of toripalimab: a next generation anti-PD-1 antibody with potent T cell activation and enhanced clinical efficacy irrespective of PD-L-1 status

Autor: Sheng Yao, Sruthi Ravindranathan, Theresa LaVallee, Sanjay D Khare, Narendiran Rajasekaran, Patricia Keegan, Xiaoguang Wang, Daniel J Chin, Su-Yi Tseng, Scott Klakamp, Kate Widmann, Varun Kapoor, Vladimir Vexler

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/be6e03e567ca486f9b68f511ad6c41df

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Akademický článek

Corrigendum to 'Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus' [Heliyon 9(4) (April 2023) e15032]

Autor: Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna

Publikováno v: Heliyon, Vol 9, Iss 8, Pp e17901- (2023)

Externí odkaz: https://doaj.org/article/9e85b30d52f24dc1a21cd1acfeca00cb

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Akademický článek

Modeling of ACE2 and antibodies bound to SARS-CoV-2 provides insights into infectivity and immune evasion

Autor: Joseph H. Lubin, Christopher Markosian, D. Balamurugan, Minh T. Ma, Chih-Hsiung Chen, Dongfang Liu, Renata Pasqualini, Wadih Arap, Stephen K. Burley, Sagar D. Khare

Publikováno v: JCI Insight, Vol 8, Iss 13 (2023)

Given the COVID-19 pandemic, there is interest in understanding ligand-receptor features and targeted antibody-binding attributes against emerging SARS-CoV-2 variants. Here, we developed a large-scale structure-based pipeline for analysis of protein-

Externí odkaz: https://doaj.org/article/dc31889fa8f7403f837661ab04c09d04

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Akademický článek

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

Publikováno v: Heliyon, Vol 9, Iss 4, Pp e15032- (2023)

The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics. However, for individuals who have contract

Externí odkaz: https://doaj.org/article/ce94e33881824004b4d691d4ee80fb5c

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Akademický článek

Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks

Autor: Julia Koehler Leman, Sergey Lyskov, Steven M. Lewis, Jared Adolf-Bryfogle, Rebecca F. Alford, Kyle Barlow, Ziv Ben-Aharon, Daniel Farrell, Jason Fell, William A. Hansen, Ameya Harmalkar, Jeliazko Jeliazkov, Georg Kuenze, Justyna D. Krys, Ajasja Ljubetič, Amanda L. Loshbaugh, Jack Maguire, Rocco Moretti, Vikram Khipple Mulligan, Morgan L. Nance, Phuong T. Nguyen, Shane Ó Conchúir, Shourya S. Roy Burman, Rituparna Samanta, Shannon T. Smith, Frank Teets, Johanna K. S. Tiemann, Andrew Watkins, Hope Woods, Brahm J. Yachnin, Christopher D. Bahl, Chris Bailey-Kellogg, David Baker, Rhiju Das, Frank DiMaio, Sagar D. Khare, Tanja Kortemme, Jason W. Labonte, Kresten Lindorff-Larsen, Jens Meiler, William Schief, Ora Schueler-Furman, Justin B. Siegel, Amelie Stein, Vladimir Yarov-Yarovoy, Brian Kuhlman, Andrew Leaver-Fay, Dominik Gront, Jeffrey J. Gray, Richard Bonneau

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Computational methods are becoming an increasingly important part of biological research. Using the Rosetta framework as an example, the authors demonstrate how community-driven development of computational methods can be done in a reproducible and r

Externí odkaz: https://doaj.org/article/7ccba8c202cd473d906c246ef7b2eb77

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