Zobrazeno 1 - 10
of 19
pro vyhledávání: '"D. Keith Anderson"'
Autor:
Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, Ahmad Y. Sheikh
Publikováno v:
Organic Process Research & Development. 13:1088-1093
Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733dff69b6ebf02a64d61a4be7a9b658
https://doi.org/10.1021/op900173f
https://doi.org/10.1021/op900173f
Autor:
Edney Albert D, Carl M. Knable, Puneh S. Karbin, Mark A. Pietz, D. Keith Anderson, Jerry D. Clark, Gerald A. Weisenburger, Donald J. Gallagher
Publikováno v:
Organic Process Research & Development. 13:60-63
The process development of a peptide coupling with CDI is discussed. Various solvents, addition orders, stoichiometries, and reaction temperatures were investigated. A reliable crystallization procedure was also developed. The new process was piloted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fac081742f6e05a791de8ebfe6610e
https://doi.org/10.1021/op8002213
https://doi.org/10.1021/op8002213
Publikováno v:
Organic Process Research & Development. 8:571-575
Studies directed toward the process research and development of a scalable method for preparing tetrahydropyrimidine 2, a key intermediate to the αvβ3 integrin antagonist 1, are described. A linear approach employing 3-amino-5-hydroxybenzoic acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66e51ecd058d17a4721b0649981a0c54
https://doi.org/10.1021/op049968w
https://doi.org/10.1021/op049968w
Autor:
Edney Albert D, Carl M. Knable, Pierre-Jean Colson, D. Keith Anderson, Thomas Rogers, Donald J. Gallagher, Ajit S. Shah, H. Peter Kleine, Jerry D. Clark, James Murphy, Christine M. V. Moore, Neil Storer, Bruce E. Wise, Peter G. Ruminski, Gerald A. Weisenburger, Melissa K. Lantz
Publikováno v:
Organic Process Research & Development. 8:51-61
Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1. Reported are an asymmetric Michael reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f87a82dd31eb7ccfa9af86ec1e1272
https://doi.org/10.1021/op034094j
https://doi.org/10.1021/op034094j
Autor:
D. Keith Anderson, James A. Sikorski
Publikováno v:
Journal of Heterocyclic Chemistry. 29:177-180
The lithiation chemistry of 1-alkyl-1H-1,2,4-triazol-5-yl phosphonic acid esters 3 has been investigated. Lithiation occurs exclusively on the 1-alkyl group, α to nitrogen, to give carbanionic intermediates 10. No evidence was found for any lithiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b05c2f85bf83a26b5274127521ce9c5
https://doi.org/10.1002/jhet.5570290132
https://doi.org/10.1002/jhet.5570290132
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 101:291-293
The lithiation chemistry of several 1-alkyl-1H-1,2,4-triazol-5-yl silanes has been investigated. Lithiation occurs exclusively on the 1-alkyl group, α to nitrogen, and on warming, an unusual anion-mediated carbon-to-carbon silicon migration occurs g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a72110eaa502c12d9bb1ca4942683ed3
https://doi.org/10.1080/10426509508042530
https://doi.org/10.1080/10426509508042530
Autor:
Gerald A. Weisenburger, D. Keith Anderson, Jerry D. Clark, Albert D. Edney, Puneh S. Karbin, Donald J. Gallagher, Carl M. Knable, Mark A. Pietz
Publikováno v:
Organic Process Research & Development; Jan2009, Vol. 13 Issue 1, p60-63, 4p
Publikováno v:
The Journal of Organic Chemistry. 46:4825-4836
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bffef93eecda62e98fd54a66619b3b1f
https://doi.org/10.1021/jo00337a002
https://doi.org/10.1021/jo00337a002
The synthesis of 6-deoxyanthracyclinones: (±)α-citromycinone and (±)4-demethoxy-6-deoxydaunomycinone
Publikováno v:
Tetrahedron. 40:4633-4642
Two synthetic approaches have been explored to prepare 6-deoxyanthracyclinones in general and α-citromycinone in particular. The first approach employed as starting materials 1,4,5-trimethoxynaphthalene and the Diels-Alder product from butadie regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae7e36952554b8acb46dc6a22cee3103
https://doi.org/10.1016/s0040-4020(01)91524-8
https://doi.org/10.1016/s0040-4020(01)91524-8
Publikováno v:
Journal of Heterocyclic Chemistry. 23:1257-1262
The metalation chemistry of several 1-substituted-1H-1,2,4-triazoles has been investigated. When various alkyl groups were incorporated in the 1-position, lithiation proceeded exclusively at C-5. The 1-trityl-, 1-methyl-, and 1-benzyl-5-lithio-1,2,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e936b458a03549890681430b04851394
https://doi.org/10.1002/jhet.5570230457
https://doi.org/10.1002/jhet.5570230457