Zobrazeno 1 - 10
of 12
pro vyhledávání: '"D. K. Rush"'
Publikováno v:
Psychopharmacology. 119:391-398
Velnacrine maleate is a novel, orally active acetylcholinesterase inhibitor of the acridine class with a longer duration of action than physostigmine. Velnacrine has shown efficacy in the treatment of Alzheimer's disease and in improving both normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b75a7692221bb96fe03bffe8e172e5
https://doi.org/10.1007/bf02245854
https://doi.org/10.1007/bf02245854
Autor:
N J, Hrib, J G, Jurcak, D E, Bregna, R W, Dunn, H M, Geyer, H B, Hartman, J E, Roehr, K L, Rogers, D K, Rush, A M, Szczepanik
Publikováno v:
Journal of Medicinal Chemistry. 35:2712-2715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efab20d65486450d86fea93088e9a317
https://doi.org/10.1021/jm00092a024
https://doi.org/10.1021/jm00092a024
Autor:
C P, Smith, G M, Bores, W, Petko, M, Li, D E, Selk, D K, Rush, F, Camacho, J T, Winslow, R, Fishkin, D M, Cunningham, K M, Brooks, J, Roehr, H B, Hartman, L, Davis, H M, Vargas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 280(2)
1-[(3-Fluoro-4-pyridinyl)amino]-3-methyl-1(H)-indol-5-yl methyl carbamate (P10358) is a potent, reversible acetylcholinesterase inhibitor that produces central cholinergic stimulation after oral and parental administration in rats and mice. P10358 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5341035c9e227d7dd84b87a3631a028e
https://pubmed.ncbi.nlm.nih.gov/9023283
https://pubmed.ncbi.nlm.nih.gov/9023283
Autor:
G M, Bores, F P, Huger, W, Petko, A E, Mutlib, F, Camacho, D K, Rush, D E, Selk, V, Wolf, R W, Kosley, L, Davis, H M, Vargas
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(2)
Acetylcholinesterase (AChE) inhibitors from several chemical classes have been tested for the symptomatic treatment of Alzheimer's disease; however, the therapeutic success of these compounds has been limited. Recently, another AChE inhibitor, galant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::adbfcdf2868fbefad406fd3f2a33a8ca
https://pubmed.ncbi.nlm.nih.gov/8627552
https://pubmed.ncbi.nlm.nih.gov/8627552
Autor:
M R, Szewczak, R, Corbett, D K, Rush, C A, Wilmot, P G, Conway, J T, Strupczewski, M, Cornfeldt
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(3)
Iloperidone (1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1- piperidinyl]propoxy]-3-methoxyphenyl]ethanone) demonstrated a potent antipsychotic profile in several in vitro and in vivo animal models. Iloperidone displaced ligand binding at D2 dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86089b5f7148e7f040e6b8ce2e1abcf6
https://pubmed.ncbi.nlm.nih.gov/7562515
https://pubmed.ncbi.nlm.nih.gov/7562515
Autor:
S, Fielding, J C, Wilker, J, Chernack, V, Ramirez, C A, Wilmot, L L, Martin, J F, Payack, M L, Cornfeldt, K A, Rudolphi, D K, Rush
Publikováno v:
Progress in clinical and biological research. 361
8319, ((+-)-2-Amino-N-ethyl-alpha-(3-methyl-2-thienyl)benzeneethanamine 2HCl), is a novel compound with the profile of a non-competitive NMDA antagonist. The compound displaced [3H] TCP with high affinity (IC50 = 43 nM), but was inactive at the NMDA,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::010a3984060d2fd49b7a8763ca585451
https://pubmed.ncbi.nlm.nih.gov/2290851
https://pubmed.ncbi.nlm.nih.gov/2290851
Autor:
R W, Dunn, R, Corbett, L L, Martin, J F, Payack, L, Laws-Ricker, C A, Wilmot, D K, Rush, M L, Cornfeldt, S, Fielding
Publikováno v:
Progress in clinical and biological research. 361
Antagonists at excitatory amino acid receptors, especially the N-methyl-d-aspartate (NMDA) subtype, have been shown to possess anticonvulsant and anxiolytic properties (Clineschmidt et al., 1982; Croucher et al., 1982; Bennett and Amrick, 1986). 7189
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17827543fdc0875ff657611f57bd5420
https://pubmed.ncbi.nlm.nih.gov/1981268
https://pubmed.ncbi.nlm.nih.gov/1981268
Publikováno v:
Drug Development Research. 4:567-576
The term “nootropic” refers to compounds that act on cognitive functions. These drugs should facilitate learning and memory and prevent impairment of cognitive functions induced by diseases and brain insults. In animal models of impaired cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ee3d7320c04450e9cdf2c6499179f9b
https://doi.org/10.1002/ddr.430040510
https://doi.org/10.1002/ddr.430040510
Publikováno v:
Diseases of the chest. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e09b12c8fd92fa3c9c2c50785d03d3fa
https://pubmed.ncbi.nlm.nih.gov/14275554
https://pubmed.ncbi.nlm.nih.gov/14275554
Publikováno v:
The Grace Hospital bulletin. 35(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::365ee64bd72599254e6613eac75d3471
https://pubmed.ncbi.nlm.nih.gov/13415440
https://pubmed.ncbi.nlm.nih.gov/13415440