Zobrazeno 1 - 10
of 53
pro vyhledávání: '"D. K. Granner"'
Autor:
Richard M. O'Brien, D K Granner, David E. Moller, Antonio Vidal-Puig, David S. Ludwig, Jeffrey S. Flier, Richard L. Printz
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:503-506
Expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis, is under dominant negative regulation by insulin. In this study, we sought to test the hypothesis that mutations in the PEPCK gene promoter may impair
Publikováno v:
Diabetes. 44:1426-1432
Autor:
Agostino Consoli, Lawrence J. Mandarino, D. K. Granner, K. A. Cusi, C. Sewell, Haruhiko Osawa, R. M. O'Doherty, R. L. Printz, P. Kinchington, Ralph A. DeFronzo
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 269:E701-E708
Insulin regulates the activity of key enzymes of glucose metabolism in skeletal muscle by altering transcription or translation or by producing activity-altering modifications of preexisting enzyme molecules. Because of the small size of percutaneous
Publikováno v:
Diabetes. 44:340-346
Publikováno v:
Diabetes. 44:290-294
Autor:
D K Granner, R Hall, A. M. Vargas, Carme Espinet, A.J. Lange, Richard J. Miksicek, M R el-Maghrabi, Simon J. Pilkis
Publikováno v:
Journal of Biological Chemistry. 267:15673-15680
At least two genes encode isoenzymes of rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Alternative splicing of one of these genes generates a skeletal muscle-specific transcript from an upstream promoter and a liver-specific transcript fro
Publikováno v:
The Journal of biological chemistry. 275(39)
Winged helix/forkhead (Fox) transcription factors have been implicated in the regulation of a number of insulin-responsive genes. The insulin response elements (IREs) of the phosphoenolpyruvate carboxykinase (PEPCK) and insulin-like growth factor-bin
Publikováno v:
The Journal of biological chemistry. 275(5)
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs), orphan members of the nuclear receptor superfamily, play a key role in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryogenic development. C
Publikováno v:
The Journal of biological chemistry. 271(25)
Hexokinase II (HKII) is the predominant isozyme expressed in peripheral insulin-responsive tissues. To explore the role of HKII in muscle glucose metabolism, two lines of transgenic mice were generated where overexpression was restricted to striated
Publikováno v:
The Journal of biological chemistry. 270(26)
Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the rate-limiting step in hepatic gluconeogenesis. Glucagon (via the second messenger cAMP) and glucocorticoids stimulate the transcription of the PEPCK gene, whereas insulin and phorbol esters inhi