'Stretch-Growth' of Motor Axons in Custom Mechanobioreactors to Generate Long-Projecting Axonal and Axonal-Myocyte Constructs

Autor: S. Das, D. K. Cullen, Kritika S. Katiyar, Laura A. Struzyna

The central feature of peripheral motor axons is their remarkable lengths as they project from a motor neuron residing in the spinal cord to an often-distant target muscle. However, to date in vitro models have not replicated this central feature owi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cddc0ac7671720e3352c0b3670e30b
https://doi.org/10.1101/598755

Development of Optically-Controlled 'Living Electrodes' with Long-Projecting Axon Tracts for a Synaptic Brain-Machine Interface

Autor: Han Chen, Dayo O. Adewole, D. K. Cullen, Dmitriy Petrov, Justin C. Burrell, Ashley D. Nemes, Laura A. Struzyna, Serruya, Reuben H. Kraft, James P. Harris, John A. Wolf

Achievements in intracortical neural interfaces are compromised by limitations in specificity and long-term performance. A biological intermediary between devices and the brain may offer improved specificity and longevity through natural synaptic int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e539d815178cae91ac54b1d26b305960
https://doi.org/10.1101/333526

Advanced biomaterial strategies to transplant preformed micro-tissue engineered neural networks into the brain

Autor: Laura A. Struzyna, Dayo O. Adewole, D. K. Cullen, E Kuo, James P. Harris, P L Murphy

Publikováno v: Journal of neural engineering. 13(1)

Objective. Connectome disruption is a hallmark of many neurological diseases and trauma with no current strategies to restore lost long-distance axonal pathways in the brain. We are creating transplantable micro-tissue engineered neural networks (mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc229d09feee57a77e1ea238e4bf31f
https://pubmed.ncbi.nlm.nih.gov/26760138

Dopaminergic Axon Tracts Within a Hyaluronic Acid Hydrogel Encasement to Restore the Nigrostriatal Pathway.

Autor: Gordián-Vélez WJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA., Browne KD; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA., Galarraga JH; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA., Chouhan D; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA., Duda JE; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., España RA; Department of Neurobiology & Anatomy, College of Medicine, Drexel University, Philadelphia, PA, 19104, USA., Chen HI; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA., Burdick JA; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; BioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA., Cullen DK; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Brain Injury & Repair, Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Center for Neurotrauma, Neurodegeneration & Restoration, Corporal Michael Crescenz Veterans Affairs Medical Center, Philadelphia, PA, 19104, USA.

Publikováno v: Advanced healthcare materials [Adv Healthc Mater] 2024 Nov 04, pp. e2402997. Date of Electronic Publication: 2024 Nov 04.

Pressure sensing system for the study of blast-induced traumatic brain injury

Autor: Xu Meng, D. K. Cullen, M. R. Tofighi, Arye Rosen

Publikováno v: 2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC).

Due to extensive use of explosive weaponry, wars in Iraq and Afghanistan have led to a significant increase in blast-induced injuries, which manifest as complicated neural cellular damage. This research is serving two purposes: 1. verifying a methodo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dc40461eced928c1da2ac256f17b1f5
https://doi.org/10.1109/nebc.2011.5778619