Výsledky vyhledávání - "D. K. A. Scheller"

Continuous drug delivery in early- and late-stage Parkinson's disease as a strategy for avoiding dyskinesia induction and expression

Autor: D. K. A. Scheller, Andrew C. McCreary, Peter Jenner

Publikováno v: Journal of Neural Transmission. 118(12):1691-1702

The treatment of the motor symptoms of Parkinson's disease (PD) is dependent on the use of dopamine replacement therapy in the form of L: -dopa and dopamine agonist drugs. However, the development of dyskinesia (chorea, dystonia, athetosis) can becom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d845eea75108e4baa24ae8ca4c81535
https://hdl.handle.net/11370/a741fae3-f74f-4f2e-a4f6-98e38fe9300d

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Transcriptional alterations under continuous or pulsatile dopaminergic treatment in dyskinetic rats

Autor: Werner J. Schmidt, D. K. A. Scheller, Edna Grünblatt, P. Riederer, Manfred Gerlach

Publikováno v: Journal of Neural Transmission. 118:1717-1725

Continuous dopaminergic treatment is considered to prevent or delay the occurrence of dyskinesia in patients with Parkinson's disease (PD). Rotigotine is a non-ergolinic D(3) D(2) D(1) dopamine-receptor agonist for the treatment of PD using a transde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13ee1e342b2fddf9d2e31e4a1ff9e9d
https://doi.org/10.1007/s00702-010-0552-y

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Continuous rotigotine administration reduces dyskinesia resulting from pulsatile treatment with rotigotine or l-DOPA in MPTP-treated common marmosets

Autor: D. K. A. Scheller, Lance A. Smith, Peter Jenner, Sarah Rose, Mahmoud M. Iravani, Michael J. Jackson, K. Stockwell

Publikováno v: Experimental Neurology. 221:79-85

We previously showed that continuous infusion of rotigotine resulted in less dyskinesia than repeated pulsatile rotigotine administration or repeated oral administration of L-DOPA in MPTP-treated marmosets. Now we investigate whether continuous rotig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5a6847b9c9d530e73550dd5e7410e3
https://doi.org/10.1016/j.expneurol.2009.10.004

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Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation

Autor: Jan Kehr, X.-J. Hu, M. Goiny, D. K. A. Scheller

Publikováno v: Journal of Neural Transmission. 114:1027-1031

Rotigotine, a non-ergolinic dopamine receptor agonist for treatment of Parkinson's disease was continuously administered over 48 h (0.5 mg/kg s.c., slow release formulation) to conscious rats striatally implanted with a microdialysis probe. Subsequen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e877ff5a7b11721dc828d52f7d3b3a1
https://doi.org/10.1007/s00702-007-0719-3

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