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Capecitabine and Vinorelbine as First-Line Treatment in Elderly Patients (≥65 Years) with Metastatic Breast Cancer

Autor: Daniel Rauch, Christoph Rochlitz, O. Pagani, S. Mattmann, A. Schönenberger, Dagmar Hess, D. Köberle, K. Ribi, Beat Thürlimann, J.C. Schuller, Pierluigi Ballabeni

Publikováno v: Oncology. 73:228-237

Background: We evaluated previously established regimens of capecitabine plus vinorelbine in older patients with advanced breast cancer stratified for presence versus absence of bone metastases. Patients and Methods: Patients ≧65 years who had rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d01d34c12d4e5c120396d080e960a60b
https://doi.org/10.1159/000127414

A prospective randomised phase-II trial with gemcitabine versus gemcitabine plus sunitinib in advanced pancreatic cancer: a study of the CESAR Central European Society for Anticancer Drug Research-EWIV

Autor: L, Bergmann, L, Maute, G, Heil, J, Rüssel, E, Weidmann, D, Köberle, S, Fuxius, K, Weigang-Köhler, W E, Aulitzky, B, Wörmann, G, Hartung, B, Moritz, L, Edler, I, Burkholder, M E, Scheulen, H, Richly

Publikováno v: European journal of cancer (Oxford, England : 1990). 51(1)

Pancreatic ductal adenocarcinoma (PDAC) is one of the most common malignant tumours and is still associated with a poor prognosis in advanced disease. To improve the standard therapy with gemcitabine, we initiated a prospective randomised phase-II tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9abb07764ab13b26e2c409c8a22e0d60
https://pubmed.ncbi.nlm.nih.gov/25459392

Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study

Autor: St. Krähenbühl, Stefan Schürch, Tanja K. Froehlich, Barbara Büchel, B. Pfister, D. Köberle, Carlo R. Largiadèr, Markus Joerger, F. Mueller

Publikováno v: CANCER CHEMOTHERAPY AND PHARMACOLOGY
Mueller, F; Büchel, B; Köberle, D; Schürch, Stefan; Pfister, B; Krähenbühl, St; Fröhlich, Tanja; Largiader, C R; Joerger, M (2013). Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study. Cancer chemotherapy and pharmacology, 71(2), pp. 361-70. Berlin: Springer 10.1007/s00280-012-2018-4

This study was initiated to assess the quantitative impact of patient anthropometrics and dihydropyrimidine dehydrogenase (DPYD) mutations on the pharmacokinetics (PK) of 5-fluorouracil (5FU) and to explore limited sampling strategies of 5FU.We inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e34b615c05ef815f56fd3e5643a966
https://pubmed.ncbi.nlm.nih.gov/23139054