AXDND1 is required to balance spermatogonial commitment and for sperm tail formation in mice and humans

Autor: Brendan J. Houston, Joseph Nguyen, D. Jo Merriner, Anne E. O’Connor, Alexandra M. Lopes, Liina Nagirnaja, Corinna Friedrich, Sabine Kliesch, Frank Tüttelmann, Kenneth I. Aston, Donald F. Conrad, Robin M. Hobbs, Jessica E. M. Dunleavy, Moira K. O’Bryan

Publikováno v: Cell Death and Disease, Vol 15, Iss 7, Pp 1-14 (2024)

Abstract Dynein complexes are large, multi-unit assemblies involved in many biological processes via their critical roles in protein transport and axoneme motility. Using next-generation sequencing of infertile men presenting with low or no sperm in

Externí odkaz: https://doaj.org/article/38d67cff45b24f41b04e0df254fa2667

Impact of Chronic Multi-Generational Exposure to an Environmentally Relevant Atrazine Concentration on Testicular Development and Function in Mice

Autor: Nicola D. Kolaitis, Bethany J. Finger, D. Jo Merriner, Joseph Nguyen, Brendan J. Houston, Moira K. O’Bryan, Jessica M. Stringer, Nadeen Zerafa, Ngoc Nguyen, Karla J. Hutt, Gerard A. Tarulli, Mark P. Green

Publikováno v: Cells, Vol 12, Iss 4, p 648 (2023)

A common herbicide, atrazine, is associated with poor health. Atrazine acts as an endocrine disruptor at supra-environmental levels. Little research, however, has been conducted regarding chronic exposure to environmental atrazine concentrations acro

Externí odkaz: https://doaj.org/article/8cd9e5dbc5724e82bdb3a848e25780d7

New Insights Into Sperm Ultrastructure Through Enhanced Scanning Electron Microscopy

Autor: Denis Korneev, D. Jo Merriner, Gediminas Gervinskas, Alex de Marco, Moira K. O’Bryan

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

The analysis of spermatozoa morphology is fundamental to understand male fertility and the etiology of infertility. Traditionally scanning electron microscopy (SEM) has been used to define surface topology. Recently, however, it has become a critical

Externí odkaz: https://doaj.org/article/fcdfac02e9054f9f9e7fda6b918769ad

DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice

Autor: Brendan J. Houston, Alexandra M. Lopes, Maris Laan, Liina Nagirnaja, Anne E. O'Connor, D. Jo Merriner, Joseph Nguyen, Margus Punab, Antoni Riera-Escamilla, Csilla Krausz, Kenneth Ivan Aston, Donald F. Conrad, Moira K. O'Bryan

Publikováno v: DEVELOPMENTAL BIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Male infertility is a common condition affecting at least 7% of men worldwide and is often genetic in origin. Using whole exome sequencing, we recently discovered three hemizygous, likely damaging variants in DDB1- and CUL4-associated factor 12-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42269eaa18f57294b5ec4985a0e11352
https://doi.org/10.1016/j.ydbio.2022.07.006

CEP76 is a critical regulator of male germ cell transition zone function and tail composition

Autor: Brendan J. Houston, D. Jo Merriner, G. Gemma Stathatos, Anne E. O’Connor, Alexandra M. Lopes, Donald F. Conrad, Mark Baker, Jessica E.M. Dunleavy, Moira K. O’Bryan

The transition zone is a specialised gate at the base of cilia/flagella, which segregates the ciliary compartment from the cytoplasm and strictly regulates protein entry. In this study, we have identified CEP76 as an essential germ cell transition zo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::079320534b1c4bfab755a5b6ba87487f
https://doi.org/10.1101/2023.03.08.531794