Using probabilistic machine learning to better model temporal patterns in parameterizations: a case study with the Lorenz 96 model

Autor: R. Parthipan, H. M. Christensen, J. S. Hosking, D. J. Wischik

Publikováno v: Geoscientific Model Development, Vol 16, Pp 4501-4519 (2023)

The modelling of small-scale processes is a major source of error in weather and climate models, hindering the accuracy of low-cost models which must approximate such processes through parameterization. Red noise is essential to many operational para

Externí odkaz: https://doaj.org/article/d99b99afda934b679a2b70e4dd894f69

Multipharmacophore strategy in medicinal chemistry for the design of drugs for the treatment of Alzheimer's and some other neurodegenerative diseases.

Autor: Bachurin, S. O., Aksinenko, A. Yu., Makhaeva, G. F., Shevtsova, E. F.

Publikováno v: Russian Chemical Bulletin; Jan2023, Vol. 72 Issue 1, p130-147, 18p

Fluorescent Phenotyping of Blood Cells Using a Differential Sensing Strategy: Differentiating Physiological Aging Stages and Neuro-Degenerative Disease Drugs.

Autor: Hoon Lee J; Department of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea., Young Yoon H; Department of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea., Lee HJ; Department of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea., Min Kang D; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Bak Y; Chemical & Biological Integrative Research Center, Biomedical Division, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Biazruchka I; Chemical & Biological Integrative Research Center, Biomedical Division, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Lim S; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Kim S; Chemical & Biological Integrative Research Center, Biomedical Division, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Kyung Kim Y; Center for Brain Disorders, Brain Science Institute, Korea Institute of Science and Technology (KIST), 02792, Seoul, Korea., Kim DH; Department of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea., Lee JS; Department of Pharmacology, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jan 22; Vol. 30 (5), pp. e202302916. Date of Electronic Publication: 2023 Nov 29.

Chemical catalyst-promoted photooxygenation of amyloid proteins.

Autor: Sohma, Youhei, Sawazaki, Taka, Kanai, Motomu

Publikováno v: Organic & Biomolecular Chemistry; 12/14/2021, Vol. 19 Issue 46, p10017-10029, 13p

Disrupted hippocampal growth hormone secretagogue receptor 1α interaction with dopamine receptor D1 plays a role in Alzheimer′s disease.

Autor: Tian, Jing, Guo, Lan, Sui, Shaomei, Driskill, Christopher, Phensy, Aarron, Wang, Qi, Gauba, Esha, Zigman, Jeffrey M., Swerdlow, Russell H., Kroener, Sven, Du, Heng

Publikováno v: Science Translational Medicine; 8/14/2019, Vol. 11 Issue 505, p1-14, 14p