Výsledky vyhledávání - "D. J. Takemoto"

Decreases in Raf-1 levels in galactosaemic lens epithelial cells are partially reversed by myo-inositol

Autor: D. J. Takemoto

Publikováno v: Acta Diabetologica. 35:145-149

Changes in the amounts and localization of protein kinase C (PKC) isoforms occur in galactosaemic lens epithelial cells. A link between PKC changes and myo-inositol depletion has been suggested. Raf-1, a component of a Ras pathway, is a substrate for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e471732a235b6a0d794bef793e88d34
https://doi.org/10.1007/s005920050119

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PKC-gamma phosphorylation of connexin 46 in the lens cortex

Autor: S M, Saleh, L J, Takemoto, D, Zoukhri, D J, Takemoto

Publikováno v: Molecular vision. 7

To identify the role of PKC-gamma in control of and phosphorylation of connexin 46 (Cx46) in the lens cortex.The association between PKC-gamma and Cx46 was determined by co-immunoprecipitation from whole lens. Phosphorylation of Cx46 and activity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6a62a35ad346676fed24292aac8fd91
https://pubmed.ncbi.nlm.nih.gov/11702063

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PKCalpha and PKCgamma overexpression causes lentoid body formation in the N/N 1003A rabbit lens epithelial cell line

Autor: L M, Wagner, D J, Takemoto

Publikováno v: Molecular vision. 7

The overexpression of PKCalpha or PKCgamma for extended periods of time causes the formation of lentoid bodies in the N/N 1003A rabbit lens epithelial cell line. To determine how differentiated the lentoid bodies are, we have looked for alphaA-, alph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d778d00e567c77cf69a7d5cb8431b2ff
https://pubmed.ncbi.nlm.nih.gov/11436000

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Effect of trichosanthin an anti-leukemia protein on normal mouse spleen cells

Autor: D J, Takemoto

Publikováno v: Anticancer research. 18(1A)

Trichosanthin, from Trichosanthes kirilowii is a member of the Cucurbitaceae family. It has been reported to have anti-cancer activity. The effects of Trichosanthin peptides (15 amino acids in length) on ConA stimulated incorporation of 3[H] thymidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c230f7cda77831a729d1466931c9eb2a
https://pubmed.ncbi.nlm.nih.gov/9568103

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Anticancer activities of 2,5,8,9-substituted 6-oxo-1,2,3,4,5,6-hexahydrophenanthridines on multi-drug-resistant phenotype cells

Autor: D H, Hua, S, Saha, D J, Takemoto

Publikováno v: Anticancer research. 17(4A)

Lycorine is a member of the alkaloid group from the bulb of the amaryllidaceae. This drug has been reported to have anticancer activity. Several synthetic intermediates obtained during the synthetic study of anticancer drugs based on the lycorine str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3dbac1f0373f31a24d6874730d704ab3
https://pubmed.ncbi.nlm.nih.gov/9252659

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Functional effect of phosphorylation of the photoreceptor phosphodiesterase inhibitory subunit by protein kinase C

Autor: I P, Udovichenko, J, Cunnick, K, Gonzalez, D J, Takemoto

Publikováno v: The Journal of biological chemistry. 269(13)

In rod outer segments the light activation of cGMP phosphodiesterase (PDE alpha beta gamma 2) is accomplished by removal of the gamma inhibitory subunit (PDE gamma) from the PDE alpha beta catalytic subunits. A light activation of the inositol signal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89ab2345872bc3f7fef9d2bf8bca9ffa
https://pubmed.ncbi.nlm.nih.gov/8144577

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Identification of the retinal cyclic GMP phosphodiesterase inhibitory gamma-subunit interaction sites on the catalytic alpha-subunit

Autor: B, Oppert, J M, Cunnick, D, Hurt, D J, Takemoto

Publikováno v: The Journal of biological chemistry. 266(25)

Retinal rod outer segment phosphodiesterase (PDE) consists of two similar catalytic subunits (alpha and beta) and two identical inhibitory subunits (gamma 2). A trypsin-activated soluble PDE exhibiting the ability to be reinhibited by PDE gamma was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da84c6065f8cd068bea5ae1d023ca565
https://pubmed.ncbi.nlm.nih.gov/1653243

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In vivo antitumor activity of the bitter melon (Momordica charantia)

Autor: C, Jilka, B, Strifler, G W, Fortner, E F, Hays, D J, Takemoto

Publikováno v: Cancer research. 43(11)

The in vivo antitumor activity of a crude extract from the bitter melon (Momordica charantia) was determined. The extract inhibited tumor formation in CBA/H mice which had been given i.p. injections of 1.0 X 10(5) CBA/Dl tumor cells (77% of the untre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f752f1395087533b1d531ffb6fb0c2b4
https://pubmed.ncbi.nlm.nih.gov/6616452

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Guanylate cyclase activity in human leukemic and normal lymphocytes. Enzyme inhibition and cytotoxicity of plant extracts

Autor: D J, Takemoto, C, Dunford, D, Vaughn, K J, Kramer, A, Smith, R G, Powell

Publikováno v: Enzyme. 27(3)

Cyclic GMP is thought to be involved in lymphocytic cell proliferation and leukemogenesis. In general, the nucleotide is elevated in leukemic vs. normal lymphocytes and changes have been reported to occur during remission and relapse of this disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::920aec2c707927e641fa39f8e89ffb8e
https://pubmed.ncbi.nlm.nih.gov/6122565

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