Zobrazeno 1 - 10 of 148 pro vyhledávání: '"D. J. Pearson"'
2
Systematic review of clinical drug development activities for neuroblastoma from 2011 to 2020
Autor: Jaclynne H, Nader, Florence, Bourgeois, Rochelle, Bagatell, Lucas, Moreno, Andrew D J, Pearson, Steven G, DuBois
Publikováno v: Pediatric Blood & Cancer. 70
Understanding the landscape of clinical trials for patients with neuroblastoma may inform efforts to improve drug development.We evaluated therapeutic trials for patients with neuroblastoma from 2011 to 2020 in our search using clinical trial informa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7956835869c16870622dcf650dbc11
https://doi.org/10.1002/pbc.30106
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5
Akademický článek
In vitro nuclear magnetic resonance spectroscopy metabolic biomarkers for the combination of temozolomide with PI3K inhibition in paediatric glioblastoma cells.
Autor: Nada M S Al-Saffar, Alice Agliano, Lynley V Marshall, L Elizabeth Jackson, Geetha Balarajah, Jasmin Sidhu, Paul A Clarke, Chris Jones, Paul Workman, Andrew D J Pearson, Martin O Leach
Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180263 (2017)
Recent experimental data showed that the PI3K pathway contributes to resistance to temozolomide (TMZ) in paediatric glioblastoma and that this effect is reversed by combination treatment of TMZ with a PI3K inhibitor. Our aim is to assess whether this
Externí odkaz: https://doaj.org/article/cb11a1ee5827424e87467afe500fd721
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7
Akademický článek
Lactate and choline metabolites detected in vitro by nuclear magnetic resonance spectroscopy are potential metabolic biomarkers for PI3K inhibition in pediatric glioblastoma.
Autor: Nada M S Al-Saffar, Lynley V Marshall, L Elizabeth Jackson, Geetha Balarajah, Thomas R Eykyn, Alice Agliano, Paul A Clarke, Chris Jones, Paul Workman, Andrew D J Pearson, Martin O Leach
Publikováno v: PLoS ONE, Vol 9, Iss 8, p e103835 (2014)
The phosphoinositide 3-kinase (PI3K) pathway is believed to be of key importance in pediatric glioblastoma. Novel inhibitors of the PI3K pathway are being developed and are entering clinical trials. Our aim is to identify potential non-invasive bioma
Externí odkaz: https://doaj.org/article/b991f104a5e54c54aa0a699f5b8655f0
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8
Akademický článek
Intrinsic susceptibility MRI identifies tumors with ALKF1174L mutation in genetically-engineered murine models of high-risk neuroblastoma.
Autor: Yann Jamin, Laura Glass, Albert Hallsworth, Rani George, Dow-Mu Koh, Andrew D J Pearson, Louis Chesler, Simon P Robinson
Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92886 (2014)
The early identification of children presenting ALK(F1174L)-mutated neuroblastoma, which are associated with resistance to the promising ALK inhibitor crizotinib and a marked poorer prognosis, has become a clinical priority. In comparing the radiolog
Externí odkaz: https://doaj.org/article/3608f06eb2fe4373837a3d9879ed5680
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10
Akademický článek
Outcome and Toxicity of an Ifosfamide-Based Soft Tissue Sarcoma Treatment Protocol in Children. The Importance of Local Therapy
Autor: S. Murray Yule, Roderick Skinner, Martin W. English, Mike Cole, Andrew D. J. Pearson, Helen H. Lucraft, Alan W. Craft
Publikováno v: Sarcoma, Vol 2, Iss 3-4, Pp 171-177 (1998)
Background. Although the survival of children with soft tissue sarcoma (STS) has improved considerably, the outcome of patients with metastatic disease, and those with primary tumours of the extremities or parameningeal sites remains disappointing. W
Externí odkaz: https://doaj.org/article/06c00972d753443580d852731bd1d6f1
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