Zobrazeno 1 - 10
of 11
pro vyhledávání: '"D. J. M. Purifoy"'
Autor:
M H St Clair, G B Roberts, Susan Mary Daluge, D. J. M. Purifoy, I K Dev, Paul Savina, J E Reardon, K M Ayers, N R Parry, P Novak
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:1590-1603
5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83) is a selective anti-human immunodeficiency virus (HIV) agent. When tested in phytohemagglutinin-stimulated normal human peripheral blood lymphocytes against fresh clinical isolates of HIV type 1 (HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e84be57ccdbf68fe18df0905bfba93f
https://doi.org/10.1128/aac.38.7.1590
https://doi.org/10.1128/aac.38.7.1590
Autor:
K. L. Powell, Margaret Tisdale, G. Darby, G. Appleyard, D. J. Nelson, D. J. M. Purifoy, W. Al Nakib, J. N. Stables, J. V. Tuttle, S. Nusinoff-Lehrman
Publikováno v:
Antiviral Chemistry and Chemotherapy. 4:281-287
A series of 2′-deoxy-2′-fluororibosides were evaluated for anti-influenza activity in cell culture and in the mouse pneumonia model. Many were found to be potent inhibitors of Influenza A, in chick embryo fibroblast cells (IC50's 0.1–2.9 μM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87d772299a233145593d336e2fefaa9
https://doi.org/10.1177/095632029300400504
https://doi.org/10.1177/095632029300400504
Autor:
G B Roberts, G. Darby, P de Miranda, S. Lacey, K. L. Powell, Lilia M. Beauchamp, S. G. Rahim, D. J. M. Purifoy, P. Ertl, Thomas A. Krenitsky
Publikováno v:
Journal of Medical Virology. 41:139-145
Research leading to the new anti-herpesvirus compounds discussed here has come from three approaches. The first approach was directed towards improving the bioavailability of acyclovir by examining the potential of a variety of prodrugs, leading to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2182cf99752b41dfd58afe84a982d75e
https://doi.org/10.1002/jmv.1890410527
https://doi.org/10.1002/jmv.1890410527
Publikováno v:
Antiviral Chemistry and Chemotherapy. 3:293-297
A series of 5-alkynyl substituted 2′-deoxyuridine and β-D-arabinofuranosyluracil nucleosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). Three promising analogues, 1-(β-D-arabinofuranosyl)-5-ethynylu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::148ddad6926e8eb70987bdccf1207b8e
https://doi.org/10.1177/095632029200300507
https://doi.org/10.1177/095632029200300507
Publikováno v:
Journal of General Virology. 72:623-630
We have applied the polymerase chain reaction (PCR) technique to analyse mutations in the thymidine kinase (TK) gene of varicella-zoster virus (VZV) associated with resistance to the 5-bromovinyl (BVaraU) and 5-propynyl (PYaraU) analogues of arabinof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45b4ea8ce6f3cbee618d990f7a34c2f1
https://doi.org/10.1099/0022-1317-72-3-623
https://doi.org/10.1099/0022-1317-72-3-623
Publikováno v:
Journal of virology. 66(4)
To understand the relationship between the primary structure and function of varicella-zoster virus thymidine kinase (VZV TK; EC 2.7.1.21), we established rapid screening and phenotypic selection of mutant VZV TK genes in TK-deficient Escherichia col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb6534757910abe20db4e0e721783fc
https://pubmed.ncbi.nlm.nih.gov/1312622
https://pubmed.ncbi.nlm.nih.gov/1312622
Autor:
George W. Koszalka, G B Roberts, D. J. M. Purifoy, James A. Fyfe, Thomas A. Krenitsky, Devron Averett
Seven 6-alkoxypurine arabinosides were synthesized and evaluated for in vitro activity against varicella-zoster virus (VZV). The simplest of the series, 6-methoxypurine arabinoside (ara-M), was the most potent, with 50% inhibitory concentrations rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ad004362a53b18f73ae696a3d50325
https://europepmc.org/articles/PMC245119/
https://europepmc.org/articles/PMC245119/
We describe the production of eight monoclonal antibodies reactive with human immunodeficiency virus type 1 reverse transcriptase (RT) by immunization of mice with purified recombinant RT. These antibodies were found to react with one or the other of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf21f82d51e2d6b46139d1be3d00e9e
https://europepmc.org/articles/PMC253508/
https://europepmc.org/articles/PMC253508/
Publikováno v:
The Journal of general virology. 65
Summary Aphidicolin, a tetracyclic diterpenoid which inhibits the DNA polymerase-α activities of many eukaryotic cells, inhibited herpes simplex virus growth and DNA synthesis in infected cultures and the activity of the virus DNA polymerase in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83d9188d50fed948ef0fd2cc2d9bfd4
https://pubmed.ncbi.nlm.nih.gov/6319564
https://pubmed.ncbi.nlm.nih.gov/6319564
A mathematical analysis of virus production with accompanying heat inactivation, from which the rate of virus release and total virus production are readily calculated, is presented. Applications of this analysis for Sindbis and Chikungunya viruses a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bf4fa4723773a5e9d8a2744a584ad4
https://europepmc.org/articles/PMC375611/
https://europepmc.org/articles/PMC375611/