Zobrazeno 1 - 10 of 11 pro vyhledávání: '"D. J. KERKMAN"'
1
Receptor Interactions of Abbott-81988, A Highly Potent, Non-Peptide Angiotensin-II Antagonist Selective for Type-1 Receptors
Autor: P. A. Morse, R B Warner, Biswanath De, K.W. Oheim, Michael E. Brune, J. Y. Lee, Martin Winn, D. J. Kerkman, Arthur A. Hancock, John F. DeBernardis, Steven A. Buckner, T.M. Zydowsky
Publikováno v: Journal of Receptor Research. 14:229-249
Abbott-81988 (A-81988) was selected from a series of related compounds as a highly potent and selective antagonist of angiotensin receptors. In the rabbit aorta, A-81988 exhibited a pA2 of 10.12 (+/- 0.08) vs. angiotensin-II, for type 1 receptors (AT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4359a7ae695c0436b5be31abef69a86
https://doi.org/10.3109/10799899409066034
Zobrazit plný text záznamu
2
Preclinical pharmacological actions of (+/-)-(1'R*,3R*)-3-phenyl-1- [1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200), a potential antidepressant agent that antagonizes alpha-2 adrenergic receptors and inhibits the neuronal uptake of norepinephrine
Autor: A A, Hancock, S A, Buckner, W J, Giardina, M E, Brune, J Y, Lee, P A, Morse, K W, Oheim, D S, Stanisic, R B, Warner, D J, Kerkman
Publikováno v: The Journal of pharmacology and experimental therapeutics. 272(3)
(+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene- dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) was evaluated in a number of biological tests to establish its pharmacological profile of activity. ABT-200 an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::932f8470d5790849c750fc87f86d7759
https://pubmed.ncbi.nlm.nih.gov/7891328
Zobrazit plný text záznamu
3
Characterization of antihypertensive activity of ABBOTT-81988, a nonpeptide angiotensin II antagonist in the renal hypertensive rat
Autor: J Y, Lee, S A, Buckner, M E, Brune, R B, Warner, M, Winn, B, De, T M, Zydowsky, T J, Opgenorth, D J, Kerkman, J F, Debernardis
Publikováno v: The Journal of pharmacology and experimental therapeutics. 268(1)
2-(N-Propyl-N[(2'-[1H-tetrazol-5-yl]biphenyl-4yl)methyl]amin o) pyridine-3-carboxylic acid (ABBOTT-81988), a novel nonpeptide angiotensin II (AII) antagonist, was evaluated to characterize its antihypertensive activity in the conscious renal hyperten
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50c51f9d40be46b30248b2e388a07af7
https://pubmed.ncbi.nlm.nih.gov/8301584
Zobrazit plný text záznamu
4
Antihypertensive activity of ABBOTT-81282, a nonpeptide angiotensin II antagonist, in the renal hypertensive rat
Autor: T.M. Zydowsky, T.J. Opgenorth, Michael E. Brune, Jang Yun Lee, Biswanath De, John F. DeBernardis, S.B. Buckner, Robert B. Warner, D. J. Kerkman, Martin Winn
Publikováno v: Pharmacology. 47(3)
ABBOTT-81282, 4-(N-butyl-N-[(2-'-[1H-tetrazol-5yl]biphenyl-4-yl)methyl]ami no) pyrimidine-5-carboxylic acid is a novel nonpeptide angiotensin II (AII) antagonist. In vivo studies were performed to evaluate ABBOTT-81282 for its antihypertensive effect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de790a5ecae786aa08f5423e187ea74c
https://pubmed.ncbi.nlm.nih.gov/8415868
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje