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Akademický článek

Pathobiological investigation of naturally infected canine rabies cases from Sri Lanka

Autor: S. Beck, P. Gunawardena, D. L. Horton, D. J. Hicks, D. A. Marston, A. Ortiz-Pelaez, A. R. Fooks, A. Núñez

Publikováno v: BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017)

Abstract Background The recommended screening of rabies in ‘suspect’ animal cases involves testing fresh brain tissue. The preservation of fresh tissue however can be difficult under field conditions and formalin fixation provides a simple altern

Externí odkaz: https://doaj.org/article/94358896872b4c8d947c0dccb15e67e1

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Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines

Autor: C Paraskeva, L C Playle, David Qualtrough, D J Hicks

Publikováno v: British Journal of Cancer

Ionising radiation is commonly used in the treatment of colorectal cancer. Tumour cells with mutant p53 undergo cell cycle arrest at G2/M after ionising radiation and evidence suggests that abrogation of this G2 arrest can lead to a premature, aberra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f1d8e1bc25d54558e32ad37987cbb1
https://pubmed.ncbi.nlm.nih.gov/12177808

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A human melanoma metastasis-suppressor locus maps to 6q16.3-q23

Autor: M E, Miele, M D, Jewett, S F, Goldberg, D L, Hyatt, C, Morelli, F, Gualandi, P, Rimessi, D J, Hicks, B E, Weissman, G, Barbanti-Brodano, D R, Welch

Publikováno v: International journal of cancer. 86(4)

Loss, deletion or rearrangement along large portions of the long arm (q-arm) of chromosome 6 occurs in80% of late-stage human melanomas, suggesting that genes controlling malignant characteristics are encoded there. Metastasis, but not tumorigenicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9f6e2587c64273af727239ecf9b8c9c2
https://pubmed.ncbi.nlm.nih.gov/10797266

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Transfection of constitutively active mitogen-activated protein/extracellular signal-regulated kinase kinase confers tumorigenic and metastatic potentials to NIH3T3 cells

Autor: D R, Welch, T, Sakamaki, R, Pioquinto, T O, Leonard, S F, Goldberg, Q, Hon, R L, Erikson, M, Rieber, M S, Rieber, D J, Hicks, J V, Bonventre, A, Alessandrini

Publikováno v: Cancer research. 60(6)

Cellular growth and differentiation are controlled by multiple extracellular signals, many of which activate extracellular signal-regulated kinase (ERK)/mitogen-activated protein (MAP) kinases. Components of the MAP kinase pathways also cause oncogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::583b2fe4981b31e0b7ec5dc03048a6d6
https://pubmed.ncbi.nlm.nih.gov/10749122

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Nuclear factor-kappaB/Rel is apoptogenic in cytokine withdrawal-induced programmed cell death

Autor: U S, Sohur, C L, Chen, D J, Hicks, F E, Yull, L D, Kerr

Publikováno v: Cancer research. 60(5)

In the complex microenvironment where they evolve, developing cells undergo rapid programmed cell death (PCD) when cytokines that support them become limiting. The transcriptional mechanisms of cytokine-withdrawal apoptosis are poorly understood. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b84a007e1db0fc85cfcd93b4ee42bf6
https://pubmed.ncbi.nlm.nih.gov/10728675

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Correlation between reduction of metastasis in the MDA-MB-435 model system and increased expression of the Kai-1 protein

Autor: K K, Phillips, A E, White, D J, Hicks, D R, Welch, J C, Barrett, L L, Wei, B E, Weissman

Publikováno v: Molecular carcinogenesis. 21(2)

Using microcell-mediated transfer of a normal chromosome 11 into the highly metastatic MDA-MB-435 human breast carcinoma cell line, we previously showed that human chromosome 11 contains a metastasis-suppressor gene for breast cancer. A known metasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::19b62ad2c4ef89c6238793fa4a4d63bd
https://pubmed.ncbi.nlm.nih.gov/9496911

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bcl-2 and bak may play a pivotal role in sodium butyrate-induced apoptosis in colonic epithelial cells; however overexpression of bcl-2 does not protect against bak-mediated apoptosis

Autor: A, Hague, G D, Diaz, D J, Hicks, S, Krajewski, J C, Reed, C, Paraskeva

Publikováno v: International journal of cancer. 72(5)

Butyrate, a short chain fatty acid produced in the colon as a result of fermentation of dietary fibre by symbiotic bacteria, induces apoptosis in colonic tumour cell lines. Three human colonic adenoma cell lines (AA/C1, RG/C2 and BH/C1) and one carci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aa32d76a68b6728c6e915d32d4391809
https://pubmed.ncbi.nlm.nih.gov/9311611

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Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (Nm23)

Autor: M E, Miele, A, De La Rosa, J H, Lee, D J, Hicks, J U, Dennis, P S, Steeg, D R, Welch

Publikováno v: Clinicalexperimental metastasis. 15(3)

Metastasis is suppressed more than 95% following microcell-mediated transfer of a single copy of neomycin-tagged human chromosome 6 (neo6) into the human melanoma cell lines C8161 and MelJuSo. Concomitant with metastasis suppression is upregulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed97627abf0703bfc81323463b9579cf
https://pubmed.ncbi.nlm.nih.gov/9174127

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