Výsledky vyhledávání - "D. J. Goodman"

Hyperacute rejection of vascularized heart transplants in BALB/c Gal knockout mice

Autor: H, Gock, E, Salvaris, L, Murray-Segal, P, Mottram, W, Han, M J, Pearse, D J, Goodman, P J, Cowan, A J, d'Apice

Publikováno v: Xenotransplantation. 7(4)

Pig-to-primate vascularized xenografts undergo hyperacute rejection (HAR). This results from pre-formed xenoreactive antibodies directed against galactose-alpha1,3-galactose (alphaGal) in the donor organ and activation of the complement cascade. We d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7aabbed6dbd538698b8123ab1f909167
https://pubmed.ncbi.nlm.nih.gov/11081758

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Synthetic peptides which inhibit the interaction between C1q and immunoglobulin and prolong xenograft survival

Autor: J P, Fryer, J R, Leventhal, W, Pao, C, Stadler, M, Jones, T, Walsh, R, Zhong, Z, Zhang, H, Wang, D J, Goodman, M, Kurek, A J, d'Apice, B, Blondin, D, Ivancic, F, Buckingham, D, Kaufman, M, Abecassis, F, Stuart, B E, Anderson

Publikováno v: Transplantation. 70(5)

Acute vascular xenograft rejection (AVXR), also termed delayed xenograft rejection (DXR), occurs when hyperacute rejection (HAR) is prevented by strategies directed at xenoreactive natural antibodies and/or complement activation. We have hypothesized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f4fc01e74e3117911b4c035b65d3045
https://pubmed.ncbi.nlm.nih.gov/11003366

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Membrane-associated lymphotoxin on natural killer cells activates endothelial cells via an NF-kappaB-dependent pathway

Autor: M, von Albertini, C, Ferran, C, Brostjan, F H, Bach, D J, Goodman

Publikováno v: Transplantation. 66(9)

Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation. We have previously demonstrated that human NK ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3f1c848738dd92ceb664ce1034c221b3
https://pubmed.ncbi.nlm.nih.gov/9825820

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Human monocytes activate porcine endothelial cells, resulting in increased E-selectin, interleukin-8, monocyte chemotactic protein-1, and plasminogen activator inhibitor-type-1 expression

Autor: M T, Millan, C, Geczy, K M, Stuhlmeier, D J, Goodman, C, Ferran, F H, Bach

Publikováno v: Transplantation. 63(3)

Monocytes (Mo) are thought to be important effector cells in early xenograft rejection. Effects of Mo-endothelial cell (EC) interactions on EC activation in vitro were studied by coculturing human Mo or human monocytoid cell lines, U937 and THP-1, wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::892a5397914cad54a57c5d181f6ed280
https://pubmed.ncbi.nlm.nih.gov/9039934

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Adenoviral-mediated overexpression of I(kappa)B(alpha) in endothelial cells inhibits natural killer cell-mediated endothelial cell activation

Autor: D J, Goodman, M A, von Albertini, A, McShea, C J, Wrighton, F H, Bach

Publikováno v: Transplantation. 62(7)

Activated natural killer (NK) cells have been found in rejecting discordant xenografts and may contribute to endothelial cell (EC) activation and damage. The transcription of genes associated with EC activation, such as E-selectin and interleukin (IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71ab47622d13972f8d95ff32831465f1
https://pubmed.ncbi.nlm.nih.gov/8878392

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Human natural killer cells induce expression of E-selectin and interleukin-8 mRNA in porcine endothelial cells

Autor: D J, Goodman, M, von Albertini, F H, Bach

Publikováno v: Transplantation proceedings. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b09aa1522eace9f52bb8519387bb37e8
https://pubmed.ncbi.nlm.nih.gov/8623300

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Direct cell contact is required to induce expression of E-selectin and IL-8 secretion in pig endothelial cells by human natural killer cells

Autor: M A, von Albertini, D J, Goodman, F H, Bach

Publikováno v: Transplantation proceedings. 28(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7a69bc0878e0ee55fc5f6e2803a8262
https://pubmed.ncbi.nlm.nih.gov/8623299

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Direct activation of porcine endothelial cells by human natural killer cells

Autor: D J, Goodman, M, Von Albertini, A, Willson, M T, Millan, F H, Bach

Publikováno v: Transplantation. 61(5)

Endothelial cell (EC) activation is a consistent feature of discordant xenograft rejection. Treatment of xenograft recipients with complement inhibitors and xenoreactive natural antibody depletion leads to delayed xenograft rejection associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aca788064b3cbb00ffc511729c0b3f7d
https://pubmed.ncbi.nlm.nih.gov/8607181

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