Výsledky vyhledávání - "D. J. Gawler"

Regulation of Cloned Cardiac L-type Calcium Channels by cGMP-dependent Protein Kinase

Autor: Dennis Wray, D. J. Gawler, Hugh A. Pearson, V A Porter, Nigel Hodson, Carol J. Milligan, Lin-Hua Jiang

Publikováno v: Journal of Biological Chemistry. 275:6135-6143

We have studied the effect of 8-bromo-cyclic GMP (8-Br-cGMP) on cloned cardiac L-type calcium channel currents to determine the site and mechanism of action underlying the functional effect. Rabbit cardiac alpha(1C) subunit, in the presence or absenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fac391ffe3ee902a02ff33fb6d2d36
https://doi.org/10.1074/jbc.275.9.6135

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The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP

Autor: A J, Davis, J T, Butt, J H, Walker, S E, Moss, D J, Gawler

Publikováno v: The Journal of biological chemistry. 271(40)

The CaLB domain is a 43-amino acid sequence motif found in a number of functionally diverse signaling proteins including three Ras-specific GTPase activating proteins (GAPs). In the Ras GTPase activating protein, P120(GAP), this domain has the abilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c8e2338018b50c13dedbe16c564bdaa8
https://pubmed.ncbi.nlm.nih.gov/8798684

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Mutation-deletion analysis of a Ca(2+)-dependent phospholipid binding (CaLB) domain within p120 GAP, a GTPase-activating protein for p21 ras

Autor: D J Gawler, L J W Zhang, M F Moran

p120 GAP is a GTPase activating protein for p21 ras. It is a multidomain protein which exhibits sequence similarity with other GTPase-activating proteins, src, pleckstrin and a central portion of the protein kinase C conserved region 2 domain known a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bd2b84b242527ff81490b888d67bf8
https://europepmc.org/articles/PMC1136674/

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CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein

Autor: D J, Gawler, L J, Zhang, M, Reedijk, P S, Tung, M F, Moran

Publikováno v: Oncogene. 10(5)

CaLB was originally observed as a conserved sequence motif in various calcium-responsive signalling proteins and also in p120 Ras GTPase activating protein (p120GAP) (Clark et al. Cell 65: 1043-1051, 1991). Here we show the 43 residue CaLB motif in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d061f40729017355491035c4ef73211
https://pubmed.ncbi.nlm.nih.gov/7898923

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Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function

Autor: M D, Houslay, D J, Gawler, G, Milligan, A, Wilson

Publikováno v: Cellular signalling. 1(1)

Hepatocyte membranes from both lean and obese Zucker rats exhibited adenylate cyclase activity that could be stimulated by glucagon, forskolin, NaF and elevated concentrations of p[NH]ppG. In membranes from lean animals, functional Gi was detected by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b650215eb7a5076cc87f067d61b3b9c
https://pubmed.ncbi.nlm.nih.gov/2561940

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