Zobrazeno 1 - 10
of 83
pro vyhledávání: '"D. J. Craik"'
Autor:
M. A. Jackson, E. K. Gilding, T. Shafee, K. S. Harris, Q. Kaas, S. Poon, K. Yap, H. Jia, R. Guarino, L. Y. Chan, T. Durek, M. A. Anderson, D. J. Craik
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Asparaginyl endopeptidases (AEPs) are plant proteases that can also function as ligases, catalyzing the production of cyclic plant peptides. Here, the authors identify structural features that govern AEP ligase activity, providing insights to aid the
Externí odkaz:
https://doaj.org/article/1a99ceed0b0643118c6ddef2be35adf9
Autor:
D. J. Craik, J. A. Jarvis
Publikováno v:
Current Medicinal Chemistry. 1:115-144
Abstract: Peptides are responsible for the regulation of a wide range of physiological functions. Their diverse biological roles, ranging from neurotransmitters to hormones, make them ideal targets for novel drug design. To utilize this potential it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66482a50851bb85cf6f214cf83ead00c
https://doi.org/10.2174/092986730102220214152941
https://doi.org/10.2174/092986730102220214152941
Publikováno v:
Molecular pharmacology. 72(6)
The synthetic alpha-conotoxin Vc1.1 is a small disulfide bonded peptide currently in development as a treatment for neuropathic pain. Unlike Vc1.1, the native post-translationally modified peptide vc1a does not act as an analgesic in vivo in rat mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f89f62df0d423ee3f8d1e3edb48645cd
https://pubmed.ncbi.nlm.nih.gov/17804600
https://pubmed.ncbi.nlm.nih.gov/17804600
Autor:
D J, Craik
Publikováno v:
IDrugs : the investigational drugs journal. 2(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bec3415f9aa397de2e43a86d542accb4
https://pubmed.ncbi.nlm.nih.gov/16113958
https://pubmed.ncbi.nlm.nih.gov/16113958
Autor:
M L, Korsinczky, H J, Schirra, K J, Rosengren, J, West, B A, Condie, L, Otvos, M A, Anderson, D J, Craik
Publikováno v:
Journal of molecular biology. 311(3)
SFTI-1 is a recently discovered cyclic peptide trypsin inhibitor from sunflower seeds comprising 14 amino acid residues. It is the most potent known Bowman-Birk inhibitor and the only naturally occurring cyclic one. The solution structure of SFTI-1 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f937f437eb1dba57a5ee272078abeb35
https://pubmed.ncbi.nlm.nih.gov/11493011
https://pubmed.ncbi.nlm.nih.gov/11493011
Publikováno v:
The Journal of biological chemistry. 276(25)
Much interest has been generated by recent reports on the discovery of circular (i.e. head-to-tail cyclized) proteins in plants. Here we report the three-dimensional structure of one of the newest such circular proteins, MCoTI-II, a novel trypsin inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a1338617c6b6a297b64438ebf8a133a0
https://pubmed.ncbi.nlm.nih.gov/11292835
https://pubmed.ncbi.nlm.nih.gov/11292835
Publikováno v:
Journal of molecular biology. 306(1)
A two-domain portion of the proteinase inhibitor precursor from Nicotiana alata (NaProPI) has been expressed and its structure determined by NMR spectroscopy. NaProPI contains six almost identical 53 amino acid repeats that fold into six highly simil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65a9483f34fbab2762fef3596d92e038
https://pubmed.ncbi.nlm.nih.gov/11178894
https://pubmed.ncbi.nlm.nih.gov/11178894
Autor:
N L, Daly, D J, Craik
Publikováno v:
The Journal of biological chemistry. 275(25)
Kalata B1 is a prototypic member of the unique cyclotide family of macrocyclic polypeptides in which the major structural features are a circular peptide backbone, a triple-stranded beta-sheet, and a cystine knot arrangement of three disulfide bonds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de616b85b33e03dff89049abdea39de1
https://pubmed.ncbi.nlm.nih.gov/10747913
https://pubmed.ncbi.nlm.nih.gov/10747913
Autor:
N F, Dawson, D J, Craik, A M, McManus, S G, Dashper, E C, Reynolds, G W, Tregear, L, Otvos, J D, Wade
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 6(1)
The 32-residue peptide, RK-1, a novel kidney-derived three disulfide-bonded member of the antimicrobial alpha-defensin family, was synthesized by the continuous flow Fmoc-solid phase method. The crude, cleaved and S-reduced linear peptide was both ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9fc250c5191cecd093fc9bbcb36871bc
https://pubmed.ncbi.nlm.nih.gov/10674716
https://pubmed.ncbi.nlm.nih.gov/10674716
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 5(10)
An increased degree of utilization of the potential N-glycosylation site in the fourth repeat unit of the human tau protein may be involved in the inability of tau to bind to the corresponding tubulin sequence(s) and in the subsequent development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17aaa9793fa9700171cb173b06c23a59
https://pubmed.ncbi.nlm.nih.gov/10580643
https://pubmed.ncbi.nlm.nih.gov/10580643