Trends and progress of oncology drug development — An analysis of the FDA oncologic drug advisory committee reviews

Autor: John K. Chan, L.M. Chen, D. Hoth, I. Amanam, Stefanie Ueda, Bradley J. Monk, Rebecca A. Brooks, Nichole Young-Lin, Daniel S. Kapp, Tuyen K. Kiet

Publikováno v: Gynecologic Oncology. 127:S11-S12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bb2e69944041b53d3186d7ece040f24
https://doi.org/10.1016/j.ygyno.2012.07.033

Risk of Major Bleeding in Cancer Patients Receiving Chemotherapy

Autor: J. Kim, M. Naghiby Sustany, Connie Chen, A. Ruiz-Valdepeñas, S. Perrin, A. Chaslerie, C. Terret, Nichole Young-Lin, K. Kim, H. Hoeffkes, M. Carvalho-Verlinde, L.C. Park, M. Kroez, Omneya Hassanain, T. van Gelder, L. Xiong, T.K. Kiet, S. Dacosta Byfield, J. Goswami, C.K. Bose, H. Bourgeois, J. Metges, A. Fani Pakdel, L. Marelli, Y. Lou, D.S. Kapp, S. Bercier, E. Lugatti, A. Costantini, R.P. Riechelmann, S. Patel, Q. Dong, J. Finek, H. Ghazal, K. Chatterjee, B. Chatterjee, G. Fasola, Z. Hu, E. Minvielle, S. J. Mukhopadhyay, W.K. Redekop, S. Abouelnaga, J.K. Chan, P. Pronzato, R. Laporta, J.H. Zong, Gary H. Lyman, M. Ghielmini, D.H.S. Brundel, A. Zimmermann, Jun Suk Kim, R. Barroso-Sousa, J. Ma, P.M. Hoff, W. Baumann, S. Banerjee, U.R. Kleeberg, François Lemare, F.K. Tauchert, M. Hipp, C. Atchison, Y. Tang, J. Menis, C. Locher, B. Cantos, S. Nawrocki, L. Zhang, E. De Droogh, M. Irwin, P. Das, G.A.M.S. (Guus) van Dongen, S.K. Sarkar, A. Olaverri Hernandez, R.W.F. van Leeuwen, G. Hebert, P. Martin Martorell, F.G.A. Jansman, A. Fourcade, B.K. Mohanti, H.J. Conter, G. Streich, J. Piquet, G. Iacono, P. Bycott, C. Bighin, C. Pedrazzani, A. Carrato, JA Santiago Crespo, A. Baitar, S. Pizzolitto, D. Debieuvre, O. Gunther, T. Collon, E. Jaeger, B. Han, I. Duran, L. Testa, M. Lambertini, J. Gutsch, J.W. Lee, D. Galdermans, S. Negrier, D. Mauri, N. Nakayama, K. Veerabudun, T. Teague, G. Spahn, M. Jofre-Bonet, Z. Brixi, M. Maglakelidze, H. Li, R. Ferreira, H. Ryu, R. Zaim, L.H. Martinez, D. Lorusso, R. Cardiga, J. Liu, F. Poggio, C. Herbstreit, M. Rezazadeh, R. von Moos, J. Pivette, J. Mebis, F. Ceia, A. Ohtsu, A. Le Thuaut, F. Blanchon, M. Weber, V. Tozzi, F. van Fraeyenhove, A.C.R.C. Ferrari, D-W. Ye, D. Pastorelli, M. Gaiardo, L. Gurrieri, S. Al-Batran, R. Eckert, A. Happe, L. Del Mastro, M.V. Karamouzis, W. Hwu, R. Li, A. Zhou, V. Petry Helena, C. Neef, J.R. Puyol, M. Laurent, C. Ortega Ruiperez, G. D'Addario, C. Fonseca, R. de Bree, M. Zaegel, M. Provencio Pulla, Sabine Tejpar, G. Rosti, L. De Fiore, Y.J. Choi, M. Fink, E. Terpos, M. Precivale, T.K. Takahashi, Tetsuji Takayama, David M. Burger, J. Feliu, M. Debus, K. Tamas, C.A. Uyl-de Groot, A. Voigt, C. Fu, E. Molinas, C. Maximiano, L. Eckert, C.O. Ruiperez, D. Bertwistle, T. Mossman, A. De Maria, C.T. Carvalho, V. Raina, C. Guillen-Ponce, H. Matthes, Arijit Mukhopadhyay, M. Muñoz Sanchez, G.M. Bariani, D. Pérez Callejo, J. Lebreton, D. Hoth, Florence Netzer, E. Liuu, A. Leitão, P. Ussetti, A. Gu, A.C. Palozzo, N. Maniadakis, Sameera Ezzat, L.G. Fonseca, E. Bria, A.T. Cohen, E.J. Batagelj, T. Yoshino, M. Sabry, A. Jirillo, N. Papadopolous, N. Cherny, I. Amanam, M. Tettamanti, J. Axtner, M.S. Mano, P. Rescigno, D. Conter, T. Tanase, S.K. Mondal, M. Blanco Villalba, Sung Heon Kim, G. Lanzetta, M. Palka, F. Schad, A. Small, D. Lueftner, R. Arai, O. Mora, Jayasri Basak, S. Piau, A. Mahmood, M. Mendez Garcia, D. Romeira, A.M. Martins, S. Schmitz, Y. Huang, S. Imbevaro, N. Marschner, Svs Deo, Ron H.J. Mathijssen, E. Meszko, F. Lobo, E. Ferrat, F. Martin, Johan Vansteenkiste, M. Molina-Garido, M.P. Mak, R.E. Buschmann-Maiworm, I. Bourlaud, A. Bedikian, Ahmad S. Alfaar, R. De Paula Costa, T. Denda, P. Anderson, J. Quidde, J. Lake, Ajay Gogia, M. Grivaux, S-H Lee, S. Vlassak, M.P. Bramajo, C. El Kouri, P. Quadri, Young-Suk Park, P. Donny, S. Gangopadhyay, A. Follador, Francesca Valent, W.S. Dai, E. Almagro Casado, S. Giraudi, J. Guo, A. Pini, M.P. Trojniak, R. Curca, M. Proença, Mohamed Kamal, M. Le Poulain-Doubliez, A. D'Alonzo, J. Pereira, N. Jokhadze, M. Di Maio, H. Hoefeler, C. Rossetto, C. Reyes, C. Hamada, E. Paillaud, Josep Tabernero, R. Gagua, C. Attali, H. Sleeboom, A. Vandebroek, G. Hechmati, J. Body, R. Wei, S. Culine, Fortunato Ciardiello, Robert A. Wolff, R. Hofheinz, P. Caillet, M.L. Gomez, Michel Ducreux, M. Rucinska, P. Hwu, A. Bahl, W. Chang, J. Douillard, Hirofumi Fujii, A. Kieszkowska-Grudny, M. Alface, F. Grude, B.J. Monk, F. Canouï-Poitrine, Nootan Kumar Shukla, A. Levaggi, D. Schrijvers, M. Urbanski, S. Rauh, S. Bastuji-Garin

Publikováno v: Annals of Oncology. 23:ix447

Cancer patients receiving chemotherapy are at increased risk of venous thromboembolism (VTE). The presence of cancer and anticoagulant use are risk factors for bleeding, yet data on bleeding risk are limited in these patients. This analysis evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65631e191932d84667ee1fa2bb6bf709
https://doi.org/10.1093/annonc/mds410

Abstract A212: First in human phase I study of PRS-050 (Angiocal), a VEGF-A targeting anticalin, in patients with advanced solid tumors: Results of a dose escalation study

Autor: D. Hoth, Hendrik Gille, A. Stern, Max E. Scheulen, M. Buechert, R. Fischer, Klaus Mross, D. Scharr, Laurent P. Audoly, Heike Richly

Publikováno v: Molecular Cancer Therapeutics. 10:A212-A212

Background: Anticalins are a new class of therapeutic small protein (20kDa) antibody mimetics based on human lipocalins which can be engineered to bind key molecules involved in tumor progression with high affinity and specificity. PRS-050 (40kDa PEG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3294b78f22f53601ed3e7b2561f2c4ba
https://doi.org/10.1158/1535-7163.targ-11-a212

Methodological issues in AIDS clinical trials. Introduction

Autor: D, Hoth

Publikováno v: Journal of acquired immune deficiency syndromes. 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d3ae8b7145fcf16bbcc0d3b290a0a1fb
https://pubmed.ncbi.nlm.nih.gov/2231297

Sensitivity of human and murine hematopoietic precursor cells to 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-glucopyranose and 1,3-bis(2-chloroethyl)-1-nitrosourea

Autor: P S, Schein, J M, Bull, D, Doukas, D, Hoth

Publikováno v: Cancer research. 38(2)

The sensitivity of mouse and human bone marrow hematopoietic precursor cells [colony-forming units committed to granulocyte-macrophage differentiatin (CFU-C)] was determined after in vitro incubation with chlorozotocin (2-[3-(2-chloroethyl)-3-nitroso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::06d2d2389c86b9c106b21afaa8b5a31f
https://pubmed.ncbi.nlm.nih.gov/620400